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fda_approved_kinase_inhibitor_library
/library/fda_approved_kinase_inhibitor_library
FDA 上市激酶抑制剂库
FDA-Approved Kinase Inhibitor Library
产品编号: L1610

激酶是一类从高能供体分子(如ATP)转移磷酸基团到特定靶分子的酶,这一过程被称为磷酸化。比较常见的激酶族群是蛋白激酶,蛋白激酶作用于特定的蛋白质,使其磷酸化而改变其活性。蛋白激酶参与了一系列细胞信号传导和调节过程,在细胞生长、代谢、分化和凋亡中发挥重要作用。蛋白激酶与许多疾病有关,包括癌症、炎性疾病、心血管疾病和神经疾病等。因此,靶向蛋白激酶已成为治疗相关疾病的一种有潜力的治疗策略。

TargetMol FDA 上市激酶库包含263 个靶向激酶的上市药物,这些激酶包括:Insulin/IGF Receptors、PI 3-Kinase、CaM Kinase II、JAK、PKA、CDK、JNK、PKC、CKI II、MAPK、RAF、EGFR、MEK、SAPK、GSK、MLCK、Src-family、IKK、PDGFR、VEGFR 等。是激酶药物开发及相关研究的有用工具。

陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
产品规格
  • 263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选;
  • 所有化合物都经过了严格的临床前研究和临床试验,由FDA、EMA、PMDA等批准上市,生物活性和安全性已经得到验证。
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。
化合物库定制
我们的化合物库可以灵活定制!了解更多
化合物库咨询
化合物库组成
Autophagy (72)
Apoptosis (57)
EGFR (35)
VEGFR (33)
c-Kit (32)
PDGFR (30)
JAK (18)
FGFR (18)
FLT (18)
Src (16)
Bcr-Abl (16)
c-Met/HGFR (14)
Tyrosine Kinases (14)
PKC (12)
CDK (12)
Raf (12)
ALK (11)
Mitophagy (10)
Antibacterial (10)
NF-κB (10)
PI3K (9)
Endogenous Metabolite (9)
AMPK (9)
c-RET (9)
Adrenergic Receptor (8)
BTK (8)
CaMK (8)
mTOR (8)
Sodium Channel (8)
Antibiotic (8)
Ferroptosis (7)
PKA (7)
Trk receptor (7)
5-HT Receptor (7)
MEK (7)
TAM Receptor (7)
Calcium Channel (6)
ERK (6)
ROCK (6)
Potassium Channel (6)
HER (6)
HIV Protease (5)
Histamine Receptor (5)
Parasite (5)
PDE (5)
ROS (5)
COX (5)
Akt (5)
AChR (5)
Ras (5)
ROS Kinase (5)
Dopamine Receptor (4)
p38 MAPK (4)
Antifungal (4)
GSK-3 (4)
Serine/threonin kinase (4)
Influenza Virus (4)
IκB/IKK (4)
Topoisomerase (3)
Glucosidase (3)
PAK (3)
IGF-1R (3)
SARS-CoV (3)
c-Fms (3)
P450 (3)
Syk (3)
FAK (3)
ROR (2)
Ligands for Target Protein for PROTAC (2)
LPL Receptor (2)
Adenosine Receptor (2)
NADPH (2)
Glutathione Peroxidase (2)
TOPK (2)
Phosphatase (2)
Serine Protease (2)
Serotonin Transporter (2)
IRE1 (2)
Hexokinase (2)
Aurora Kinase (2)
Lipoxygenase (2)
Interleukin (2)
DNA/RNA Synthesis (2)
MAPK (2)
P-gp (2)
Ephrin Receptor (2)
Nrf2 (2)
TNF (2)
Microtubule Associated (2)
Tyrosinase (2)
S1P Receptor (2)
PKM (2)
Chloride channel (1)
Proton pump (1)
Transferase (1)
DHFR (1)
DNA-PK (1)
HCV Protease (1)
Integrin (1)
Estrogen/progestogen Receptor (1)
Dehydrogenase (1)
YAP (1)
Antioxidant (1)
IFNAR (1)
JNK (1)
gp120/CD4 (1)
Virus Protease (1)
Melatonin Receptor (1)
HBV (1)
PPAR (1)
Hck (1)
Antifolate (1)
Nucleoside Antimetabolite/Analog (1)
Caspase (1)
TRP/TRPV Channel (1)
CSF-1R (1)
LDL (1)
GRK (1)
Phosphorylase (1)
Mitochondrial Metabolism (1)
Monoamine Transporter (1)
Reactive Oxygen Species (1)
HSV (1)
IL Receptor (1)
Chk (1)
PAD (1)
ACK (1)
GluR (1)
Norepinephrine (1)
DNA (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
TGF-beta/Smad (1)
ATP Citrate Lyase (1)
AChE (1)
Antiviral (1)
Sirtuin (1)
Beta Amyloid (1)
HDAC (1)
Hydroxylase (1)
PLK (1)
Gap Junction Protein (1)
Anti-infection (1)
NADPH-oxidase (1)
S6 Kinase (1)
Sigma receptor (1)
HIF/HIF Prolyl-Hydroxylase (1)
NO Synthase (1)
化合物库信息示例
Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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