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drug_fragment_library
/library/drug_fragment_library
药物片段库
Drug-Fragment Library
产品编号: L8800

近年来,FBDD 方法受到许多药物研发人员的关注。利用FBDD 方法已成功产生了3种上市药物(Vemurafenib、Venetoclax 和Erdafitinib)和30多种临床期药物,表明该技术具有较好的应用前景。

同一药物的不同分子片段可以分别出现在其他的药物结构中,这些片段结构与药物的药理药效性质存在一定的相关性,利用这些片段分子进行药物设计可能更容易寻找到具有理想药物性质的活性先导化合物。

高质量的片段库能够提高FBDD 筛选命中率,增加筛选成功率。Targetmol 对2080种上市药物和1100种临床期药物进行片段化处理和层层筛选,构建了一个由1119 种片段分子组成的药物片段库,是基于FBDD 药物筛选的有力工具。

陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
产品规格
  • 数量:1119种药物片段分子,是FBDD方法新药筛选的有力工具;
  • 药化性质:超过53%的片段完全符合Ro3原则,所有片段均可找到对应药物,具有更佳的成药潜力;
  • 质量保证:NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高;
  • 适用方法多样:适合SPR,核磁,X射线单晶衍射等多种检测手段进行新药开发。
化合物库定制
我们的化合物库可以灵活定制!了解更多
化合物库咨询
化合物库组成
Endogenous Metabolite (89)
Antibacterial (75)
Antibiotic (72)
Autophagy (66)
Apoptosis (53)
COX (43)
Adrenergic Receptor (31)
DNA/RNA Synthesis (29)
5-HT Receptor (29)
AChR (25)
Parasite (24)
Sodium Channel (23)
Dopamine Receptor (22)
Nucleoside Antimetabolite/Analog (18)
HIV Protease (17)
Antifungal (17)
Histamine Receptor (17)
MAO (14)
PDE (14)
Dehydrogenase (11)
Influenza Virus (11)
GABA Receptor (10)
Monoamine Oxidase (10)
Adenosine Receptor (9)
Mitophagy (9)
Virus Protease (9)
Calcium Channel (9)
iGluR (9)
HSV (9)
Reverse Transcriptase (9)
NF-κB (9)
Estrogen/progestogen Receptor (8)
PPAR (8)
Norepinephrine (8)
AChE (8)
P450 (8)
Potassium Channel (8)
Carbonic Anhydrase (7)
Ferroptosis (7)
DNA Alkylator/Crosslinker (7)
HBV (7)
Reactive Oxygen Species (7)
Estrogen Receptor/ERR (6)
GluR (6)
Amino Acids and Derivatives (5)
Serotonin Transporter (5)
ROS (5)
Lipoxygenase (5)
EGFR (5)
TNF (5)
Thyroid hormone receptor(THR) (4)
ATPase (4)
DHFR (4)
HCV Protease (4)
Melatonin Receptor (4)
MRP (4)
TRP/TRPV Channel (4)
Drug Metabolite (4)
Opioid Receptor (4)
DNA Alkylation (4)
Prostaglandin Receptor (4)
HDAC (4)
Aromatase (4)
AMPK (4)
DNA Methyltransferase (4)
Tyrosinase (4)
NO Synthase (4)
Chloride channel (3)
CAT (3)
Transferase (3)
Glutathione Peroxidase (3)
PKA (3)
Antifolate (3)
NMDAR (3)
Antifection (3)
Molecular Glues (3)
Fatty Acid Synthase (3)
IL Receptor (3)
Antiviral (3)
SARS-CoV (3)
Ligand for E3 Ligase (3)
Phospholipase (3)
Adenosine deaminase (3)
Microtubule Associated (3)
HIF/HIF Prolyl-Hydroxylase (3)
NOS (2)
c-Met/HGFR (2)
NADPH (2)
Factor Xa (2)
ABC (2)
PKC (2)
ERK (2)
Topoisomerase (2)
MT Receptor (2)
Mitochondrial Metabolism (2)
MMP (2)
Xanthine Oxidase (2)
CaMK (2)
Interleukin (2)
Free radical scavengers (2)
Nrf2 (2)
STAT (2)
Retinoid Receptor (2)
FGFR (2)
Thrombin (2)
AhR (2)
Imidazoline Receptor (2)
advanced glycation end products (1)
Taste receptor (1)
Monocarboxylate transporter (1)
Hydrogenase (1)
ROR (1)
CYP19A1 (1)
Histone Methyltransferase (1)
YAP (1)
PI3K (1)
Antioxidant (1)
Reductase (1)
Histone Demethylase (1)
RAAS (1)
JNK (1)
Phosphatase (1)
Progesterone Receptor (1)
GSK-3 (1)
Tyrosine Kinases (1)
Wnt/beta-catenin (1)
PARP (1)
Rho (1)
Serine/threonin kinase (1)
VEGFR (1)
Caspase (1)
Aryl Hydrocarbon Receptor (1)
IAP (1)
UGT (1)
BCL (1)
JAK (1)
PDGFR (1)
PAK (1)
FAAH (1)
CCR (1)
CXCR (1)
Endothelin Receptor (1)
Epigenetic Reader Domain (1)
DNA (1)
DUB (1)
Androgen Receptor (1)
Telomerase (1)
TGF-beta/Smad (1)
Akt (1)
PGE Synthase (1)
Beta-Secretase (1)
Glutathione reductase (1)
Acyltransferase (1)
TLR (1)
Sirtuin (1)
Decarboxylase (1)
Pyroptosis (1)
RSV (1)
IκB/IKK (1)
GST (1)
CRISPR/Cas9 (1)
GPR (1)
PLK (1)
MEK (1)
Gap Junction Protein (1)
Platelet aggregation (1)
Syk (1)
NOD (1)
FAK (1)
NOD-like Receptor (NLR) (1)
CFTR (1)
p53 (1)
PD-1/PD-L1 (1)
化合物库信息示例
Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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