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cytoskeletal_signaling_pathway_compound_library
/library/cytoskeletal_signaling_pathway_compound_library
细胞骨架化合物库
Cytoskeletal Signaling Pathway Compound Library
产品编号: L1310

细胞骨架作为真核细胞中的动态蛋白纤维网结构,由微丝(microfilaments, MF)、微管(microtubules, MT)和中间纤维 (intermediate filaments, IF) 构成。微丝确定细胞表面特征,使细胞能够运动和收缩。微管确定膜性细胞器(membrane-enclosed organelle)的位置和作为膜泡运输的导轨。中间纤维使细胞具有张力和抗剪切力。

细胞骨架是细胞生命活动不可缺少的细胞结构,其形成的复杂网络体系对细胞形态的改变和维持、细胞的分裂与分化、细胞内的物质运输、细胞信息传递和基因表达等均具有重大的意义。细胞骨架结构发生异常往往与一些疾病有关。如阿尔茨海默症患者,在脑神经元中发现有大量扭曲变形的微管和大量受损的中间纤维;在恶性转化的细胞中,常表现为微管减少和解聚,细胞骨架异常可增强癌细胞的运动能力。

TargetMol 细胞骨架化合物库收集了759 种细胞骨架相关的化合物,作用靶点包括Microtubule/Tubulin、Kinesin、PKC、MAPK 等,可用于细胞骨架信号通路与相关疾病的药理研究和药物开发。

陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
产品规格
  • 759种细胞骨架相关的化合物,可以用于高通量和高内涵筛选;
  • 作用于细胞骨架相关的靶点,如Microtubule/Tubulin、Kinesin、PKC、MAPK等;
  • 部分化合物已经得到FDA批准上市;
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。
化合物库定制
我们的化合物库可以灵活定制!了解更多
化合物库咨询
化合物库组成
Apoptosis (142)
Microtubule Associated (108)
Autophagy (102)
p38 MAPK (96)
Akt (92)
Wnt/beta-catenin (90)
PKC (77)
Bcr-Abl (62)
HSP (56)
MAPK (49)
ROCK (40)
Src (35)
Integrin (35)
NF-κB (30)
FAK (29)
ERK (27)
PI3K (22)
PKA (22)
Parasite (21)
Antibacterial (20)
VEGFR (19)
Endogenous Metabolite (19)
Kinesin (19)
PAK (18)
c-Kit (18)
CDK (17)
mTOR (16)
JNK (15)
PDGFR (15)
Myosin (14)
PARP (13)
Antibiotic (13)
Rho (12)
Caspase (12)
Reactive Oxygen Species (12)
COX (11)
TNF (11)
S6 Kinase (11)
BCL (10)
IGF-1R (10)
Aurora Kinase (9)
STAT (9)
FGFR (9)
Antifungal (8)
GSK-3 (8)
Casein Kinase (8)
FLT (8)
Dynamin (7)
Raf (7)
EGFR (7)
AMPK (7)
HIV Protease (6)
JAK (6)
ALK (6)
Influenza Virus (6)
MEK (6)
Gap Junction Protein (6)
Ras (6)
ATPase (5)
c-Met/HGFR (5)
Tyrosine Kinases (5)
PPAR (5)
Serine/threonin kinase (5)
PYK2 (5)
Topoisomerase (5)
IL Receptor (5)
MMP (5)
CaMK (5)
ASK (5)
NO Synthase (5)
Ferroptosis (4)
Calcium Channel (4)
Lipoxygenase (4)
DNA/RNA Synthesis (4)
TLR (4)
GPR (4)
PDK (4)
SGK (4)
Syk (4)
p53 (4)
Mitophagy (3)
Virus Protease (3)
Serine Protease (3)
LDL (3)
Gamma-secretase (3)
Mitochondrial Metabolism (3)
Antifection (3)
HSV (3)
ACK (3)
P-gp (3)
Porcupine (3)
SARS-CoV (3)
Trk receptor (3)
c-Fms (3)
HIF (3)
c-RET (3)
S1P Receptor (3)
HER (3)
Carbonic Anhydrase (2)
HCV Protease (2)
MyD88 (2)
Antioxidant (2)
LPL Receptor (2)
RAAS (2)
Hck (2)
Adrenergic Receptor (2)
GRK (2)
Drug Metabolite (2)
BTK (2)
Guanylate cyclase (2)
DNA Alkylation (2)
PTEN (2)
Chk (2)
KSP (2)
Epigenetic Reader Domain (2)
TGF-beta/Smad (2)
MNK (2)
Antiviral (2)
Prostaglandin Receptor (2)
Ephrin Receptor (2)
transporter (2)
Nrf2 (2)
Beta Amyloid (2)
HDAC (2)
AChR (2)
MLK (2)
Monoamine Oxidase (2)
Apelin receptor (1)
Mdm2 (1)
PROTACs (1)
DHFR (1)
Ligands for Target Protein for PROTAC (1)
Estrogen/progestogen Receptor (1)
YAP (1)
Arginase (1)
Adenosine Receptor (1)
DYRK (1)
NADPH (1)
PERK (1)
Histamine Receptor (1)
Tie-2 (1)
Glutathione Peroxidase (1)
Phosphatase (1)
MRP (1)
HBV (1)
Estrogen Receptor/ERR (1)
Nucleoside Antimetabolite/Analog (1)
FXR (1)
Glucokinase (1)
NAMPT (1)
TRP/TRPV Channel (1)
Aryl Hydrocarbon Receptor (1)
PDE (1)
Glucosidase (1)
Hedgehog/Smoothened (1)
DNA (1)
DUB (1)
Androgen Receptor (1)
LRRK2 (1)
Aminopeptidase (1)
MELK (1)
Methionine Adenosyltransferase (MAT) (1)
IκB/IKK (1)
GST (1)
Aromatase (1)
CRISPR/Cas9 (1)
5-HT Receptor (1)
PLK (1)
Cannabinoid Receptor (1)
Complement System (1)
Potassium Channel (1)
IRAK (1)
HIF/HIF Prolyl-Hydroxylase (1)
AhR (1)
化合物库信息示例
Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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