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cuproptosis_compound_library
/library/cuproptosis_compound_library
铜死亡化合物库
Cuproptosis Compound Library
产品编号: L8710

铜离子是所有生物必不可少的辅助因子,但当其浓度超过一定阈值时,就会对机体产生毒害作用。铜死亡的发生机制明显区别于已知的细胞凋亡、焦亡、坏死及铁死亡的细胞死亡方式:铜离子通过直接结合三羧酸(TCA)循环途径中的脂酰化成分,导致脂酰化蛋白异常聚集以及铁硫簇蛋白的丢失,从而导致蛋白质毒性应激反应并导致细胞死亡。铜死亡与肌萎缩侧索硬化症(ALS)、乳腺癌、黑色素瘤、成神经细胞瘤、和前列腺癌等疾病有关。 TargetMol 铜死亡化合物库集合了 400 种与铜死亡相关的化合物,可以用于铜死亡机制及相关疾病研究

陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
产品规格
  • 400 种与铜死亡相关的活性小分子,可用于高通量和高内涵筛选;
  • 靶向FDX1,胞浆金属伴侣(ATOX1),CCS (copper chaperones),线粒体呼吸等;
  • 部分化合物已被FDA批准上市;
  • 详细的说明书,化合物结构、靶点信息、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。
化合物库定制
我们的化合物库可以灵活定制!了解更多
化合物库咨询
化合物库组成
Reactive Oxygen Species (153)
Autophagy (100)
Apoptosis (99)
BCL (58)
Endogenous Metabolite (55)
Mitophagy (52)
ROS (51)
Mitochondrial Metabolism (49)
Antibacterial (30)
COX (19)
NF-κB (17)
Ferroptosis (16)
HIV Protease (15)
Antioxidant (13)
PDE (13)
Antifungal (12)
Caspase (12)
IAP (12)
Antibiotic (12)
Parasite (11)
HSP (10)
Influenza Virus (10)
Dehydrogenase (8)
Topoisomerase (8)
IL Receptor (8)
ROS Kinase (8)
PKM (8)
Calcium Channel (7)
HIF/HIF Prolyl-Hydroxylase (7)
NO Synthase (7)
ATPase (6)
p38 MAPK (6)
Estrogen/progestogen Receptor (6)
PARP (6)
ALK (6)
HDAC (6)
P450 (6)
TNF (6)
PI3K (5)
PPAR (5)
MMP (5)
Xanthine Oxidase (5)
Akt (5)
Nrf2 (5)
AMPK (5)
GABA Receptor (5)
p53 (5)
NOS (4)
c-Met/HGFR (4)
NADPH (4)
Virus Protease (4)
PKC (4)
E1/E2/E3 Enzyme (4)
DNA/RNA Synthesis (4)
Histamine Receptor (3)
JNK (3)
Wnt/beta-catenin (3)
VEGFR (3)
ERK (3)
Gamma-secretase (3)
JAK (3)
HSV (3)
Lipoxygenase (3)
mTOR (3)
P-gp (3)
Trk receptor (3)
IκB/IKK (3)
5-HT Receptor (3)
Potassium Channel (3)
FLT (3)
Sodium Channel (3)
Microtubule Associated (3)
Chloride channel (2)
Monocarboxylate transporter (2)
ROR (2)
HCV Protease (2)
Dynamin (2)
RAAS (2)
HBV (2)
Estrogen Receptor/ERR (2)
Tyrosine Kinases (2)
Cysteine Protease (2)
Adrenergic Receptor (2)
MAO (2)
IRE1 (2)
Opioid Receptor (2)
PDGFR (2)
Epigenetic Reader Domain (2)
IGF-1R (2)
Interleukin (2)
OXPHOS (2)
TLR (2)
SARS-CoV (2)
Beta Amyloid (2)
Reverse Transcriptase (2)
STAT (2)
PDK (2)
Phospholipase (2)
AChR (2)
c-Kit (2)
Anti-infection (2)
HMG-CoA Reductase (2)
CFTR (2)
Proteasome (1)
Mdm2 (1)
CAT (1)
Carbonic Anhydrase (1)
Src (1)
MyD88 (1)
Ligands for Target Protein for PROTAC (1)
YAP (1)
Adenosine Receptor (1)
IFNAR (1)
aconitase (1)
RAR/RXR  (1)
Histone Demethylase (1)
Glutathione Peroxidase (1)
Phosphatase (1)
Melatonin Receptor (1)
PKA (1)
FXR (1)
TRP/TRPV Channel (1)
Amylase (1)
Glucocorticoid Receptor (1)
Immunology/Inflammation related (1)
Annexin A (1)
UGT (1)
CDK (1)
Drug Metabolite (1)
Phosphorylase (1)
NMDAR (1)
Hexokinase (1)
Hedgehog/Smoothened (1)
FAAH (1)
Somatostatin (1)
GluR (1)
cAMP (1)
CaMK (1)
DNA (1)
Androgen Receptor (1)
TGF-beta/Smad (1)
SGLT (1)
Glutathione reductase (1)
AChE (1)
Antiviral (1)
Prostaglandin Receptor (1)
STING (1)
LRRK2 (1)
Aminopeptidase (1)
Free radical scavengers (1)
Sirtuin (1)
Histone Acetyltransferase (1)
RSV (1)
Casein Kinase (1)
ATM/ATR (1)
GST (1)
Retinoid Receptor (1)
Aromatase (1)
CRISPR/Cas9 (1)
GPR (1)
HIF (1)
MEK (1)
FGFR (1)
Discoidin Domain Receptor (DDR) (1)
Platelet aggregation (1)
Syk (1)
NOD (1)
NADPH-oxidase (1)
IRAK (1)
S6 Kinase (1)
Tyrosinase (1)
Thrombin (1)
NOD-like Receptor (NLR) (1)
AhR (1)
Monoamine Oxidase (1)
化合物库信息示例
Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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