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cns_penetrant_compound_library
/library/cns_penetrant_compound_library
血脑屏障通透化合物库
CNS-Penetrant Compound Library
产品编号: L5900

血脑屏障是由毛细血管内皮细胞及其之间的紧密链接组成,保护大脑免受外界异质物质的破坏,限制物质分子扩散进入中枢神经系统,由于血脑屏障的阻碍作用,脑肿瘤等疾病的化疗功效也受到很大影响。因此治疗大多数脑疾病的主要挑战是将治疗药物穿过血脑屏障递送到大脑的特定区域,在针对 CNS 靶标筛选库的设计中选择能够穿透血脑屏障的分子,对于整个 CNS 药物发现过程起着至关重要的作用。

基于相关文献报道及如下五个原则:(1)化学结构上亲脂性好,亲水性弱;(2)和血浆蛋白的结合弱;(3)分子量不宜过大;(4)已经证实的可以通过血脑屏障起作用的上市药物和临床药物;(5)和 CNS 相关靶点对应的小分子,我们精心挑选了 509 个化合物,这些化合物都可以穿过血脑屏障、有明确作用靶点、生物活性验证有效,用于 CNS-Penetrant 相关的研究及中枢神经系统疾病药物的筛选,可用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
产品规格
  • 509 个CNS-Penetrant生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
  • 靶点包括激酶、GPCR和离子通道等;
  • 是脑肿瘤、精神障碍和神经退行性疾病等脑疾病药物筛选的有效工具;
  • 结构多样,药效显著,可渗透血脑屏障和细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。
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化合物库组成
Autophagy (107)
Apoptosis (86)
5-HT Receptor (53)
Dopamine Receptor (40)
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AChR (32)
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Mitophagy (18)
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Calcium Channel (16)
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化合物库信息示例
Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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