抗抑郁症化合物库

Antidepressant Compound Library

产品编号： L9860

抑郁症是一种常见的精神障碍，世界卫生组织（WHO）发布的统计报告显示，世界上有超过3.5亿人受抑郁症困扰，并且还在快速增长中。抑郁症主要表现为注意力不集中、情绪低落、思维迟缓、睡眠紊乱，食欲体重变化等症状，还会产生悲观厌世甚至自杀想法，每年有超过80万人因抑郁症自杀身亡。药物治疗作为抑郁症治疗的主要手段，近几十年来开发了一系列抗抑郁药物，但现有抗抑郁药物有一定的局限性，如临床效应滞后或低反应，以及一系列潜在的副作用，抗抑郁药物的发展和抑郁症的发病相比相对比较缓慢，开发抗抑郁症药物已被WHO 列入21世纪迫切开发的药物 TargetMol 抗抑郁症化合物库收集了1163 种与抑郁症相关的化合物，包括已经报道具有抑郁症治疗作用的化合物，以及靶向抑郁症相关靶点的化合物，是抗抑郁症药物研发的良好工具。

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

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产品描述

1163种与抑郁症相关的化合物，可以用于高通量和高内涵筛选；
部分化合物已上市或已进入临床期；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

NF-κB (185)

PI3K (168)

Apoptosis (154)

5-HT Receptor (137)

Autophagy (136)

mTOR (88)

Akt (86)

Dopamine Receptor (82)

NMDAR (66)

AMPK (66)

Endogenous Metabolite (60)

GSK-3 (55)

Reactive Oxygen Species (47)

Adrenergic Receptor (40)

iGluR (40)

Antibacterial (38)

Monoamine Oxidase (38)

DNA-PK (37)

Serotonin Transporter (36)

GABA Receptor (36)

ERK (31)

COX (30)

CDK (29)

S6 Kinase (29)

Norepinephrine (28)

MAO (27)

IκB/IKK (27)

p38 MAPK (26)

ATM/ATR (23)

Parasite (21)

GluR (21)

TNF (21)

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Influenza Virus (12)

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PKA (10)

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Src (9)

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Antioxidant (9)

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MAPK (9)

MEK (9)

NOD (9)

NOD-like Receptor (NLR) (9)

VEGFR (8)

DNA/RNA Synthesis (8)

Casein Kinase (8)

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HCV Protease (3)

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transporter (3)

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Estrogen/progestogen Receptor (2)

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Arrestin (1)

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Mdm2 (1)

NPC1L1 (1)

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LTR (1)

IFNAR (1)

PERK (1)

OCT (1)

Serine/threonin kinase (1)

Glucokinase (1)

RANKL/RANK (1)

Glucocorticoid Receptor (1)

Myosin (1)

HBV (1)

Pim (1)

Hck (1)

Liver X Receptor (1)

FXR (1)

Immunology/Inflammation related (1)

GRK (1)

P2X Receptor (1)

GlyT (1)

Antifection (1)

Monoamine Transporter (1)

Fatty Acid Synthase (1)

DNA (1)

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ATP Citrate Lyase (1)

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STING (1)

LRRK2 (1)

Sirtuin (1)

PAK (1)

Hedgehog/Smoothened (1)

CCR (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Telomerase (1)

Aminopeptidase (1)

GST (1)

c-Fms (1)

LPA Receptor (1)

DAPK (1)

HMG-CoA Reductase (1)

cholecystokinin (1)

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MLK (1)

PKM (1)

CRFR (1)

ALK (1)

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Oxytocin Receptor (1)

Adenosine deaminase (1)

Syk (1)

c-Kit (1)

NADPH-oxidase (1)

lysosomal autophagy (1)

Kinesin (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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