抗胰腺癌化合物库

Anti-Pancreatic Cancer Compound Library

产品编号： L2192

随着医学技术的进步，大部分癌症的生存率都在提高，例如乳腺癌，结直肠癌等肿瘤，近几十年来，生存率得到了大幅度的提升。但是，有一个例外，那就是胰腺癌，胰腺癌是一种发病隐匿，进展迅速，治疗效果和预后极差的消化道恶性肿瘤。胰腺癌的生存率一直停滞不前，胰腺癌的五年生存率只有5%至10%，绝大部分患者在诊断胰腺癌半年内死亡，由于生存率低，死亡率高，胰腺癌称为癌中之王。

为了满足胰腺癌研究客户的需求，TargeMol 收集了 2238 种与胰腺癌相关的化合物，作用于 KRas, MEK, ERK, RAF, PI3K, HER2, EGFR, JAK/STAT, IGF-1R, VEGF, TGFβ等胰腺癌相关靶点，助力胰腺癌治疗药物的开发。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品特点

2238种与胰腺癌相关的化合物，可以用于高通量和高内涵筛选；
靶点含KRas, MEK, ERK, RAF, PI3K, HER2, EGFR, JAK/STAT, IGF-1R, VEGF, TGFβ等；
部分化合物已上市或已进入临床期；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库组成

Apoptosis (406)

Autophagy (289)

NF-κB (227)

CDK (183)

PI3K (172)

COX (169)

EGFR (160)

VEGFR (146)

PPAR (116)

HDAC (102)

JAK (96)

Akt (93)

ERK (92)

Src (91)

mTOR (90)

STAT (86)

AMPK (76)

FGFR (75)

PARP (72)

p38 MAPK (70)

PDGFR (66)

Raf (65)

Endogenous Metabolite (61)

Antibacterial (60)

GSK-3 (57)

FLT (54)

TGF-beta/Smad (51)

c-Kit (49)

Ras (46)

MEK (44)

JNK (41)

MMP (41)

HER (41)

DNA-PK (37)

p53 (37)

Parasite (35)

Bcr-Abl (34)

Reactive Oxygen Species (34)

TNF (33)

Tyrosine Kinases (32)

Caspase (31)

IGF-1R (31)

S6 Kinase (30)

Ferroptosis (28)

c-Met/HGFR (28)

Aurora Kinase (28)

MAPK (27)

HIF/HIF Prolyl-Hydroxylase (27)

DNA/RNA Synthesis (26)

Mitophagy (25)

IL Receptor (24)

ALK (24)

Influenza Virus (23)

ATM/ATR (23)

Potassium Channel (23)

c-RET (22)

Antibiotic (22)

HIV Protease (21)

E1/E2/E3 Enzyme (21)

P450 (21)

HIF (21)

Pim (20)

PKC (20)

Gamma-secretase (20)

Antifungal (19)

PDK (19)

Mdm2 (18)

BCL (18)

Lipoxygenase (18)

PKA (16)

Dehydrogenase (15)

Wnt/beta-catenin (15)

FAK (15)

NO Synthase (15)

Calcium Channel (14)

Casein Kinase (14)

PI4K (14)

NOS (13)

Topoisomerase (13)

Interleukin (13)

Prostaglandin Receptor (13)

IκB/IKK (13)

Beta Amyloid (12)

c-Fms (12)

Tyrosinase (12)

Virus Protease (11)

Rho (11)

PDE (11)

Chk (11)

Sirtuin (11)

Nrf2 (11)

Trk receptor (10)

Sodium Channel (10)

ROCK (9)

ROS (9)

HSV (9)

TAM Receptor (9)

HCV Protease (8)

Phosphatase (8)

Adrenergic Receptor (8)

Antioxidant (7)

BTK (7)

PTEN (7)

Epigenetic Reader Domain (7)

PGE Synthase (7)

P-gp (7)

TLR (7)

Ephrin Receptor (7)

GABA Receptor (7)

Microtubule Associated (7)

Proteasome (6)

ATPase (6)

Estrogen/progestogen Receptor (6)

Adenosine Receptor (6)

PERK (6)

Aryl Hydrocarbon Receptor (6)

CSF-1R (6)

SIK (6)

Mitochondrial Metabolism (6)

HSP (6)

PLK (6)

AChR (6)

Syk (6)

Anti-infection (6)

Carbonic Anhydrase (5)

Integrin (5)

Tie-2 (5)

IAP (5)

Drug Metabolite (5)

Antiviral (5)

transporter (5)

MELK (5)

GPR (5)

5-HT Receptor (5)

SGK (5)

Chloride channel (4)

Transferase (4)

DYRK (4)

Estrogen Receptor/ERR (4)

Serine Protease (4)

Hck (4)

Nucleoside Antimetabolite/Analog (4)

TRP/TRPV Channel (4)

LDL (4)

Antifection (4)

CCR (4)

CaMK (4)

Androgen Receptor (4)

AChE (4)

IRAK (4)

cholecystokinin (4)

MLK (4)

Histone Methyltransferase (3)

DNA Alkylator/Crosslinker (3)

BACE (3)

RAAS (3)

Histamine Receptor (3)

Glutathione Peroxidase (3)

GTPase (3)

c-Myc (3)

MRP (3)

HBV (3)

Serine/threonin kinase (3)

Leukotriene Receptor (3)

PYK2 (3)

Glucocorticoid Receptor (3)

Immunology/Inflammation related (3)

RIP kinase (3)

Glucosidase (3)

Opioid Receptor (3)

SARS-CoV (3)

LRRK2 (3)

Free radical scavengers (3)

Retinoid Receptor (3)

Phospholipase (3)

Cannabinoid Receptor (3)

NOD-like Receptor (NLR) (3)

Proton pump (2)

Dopamine Receptor (2)

ROR (2)

IFNAR (2)

Reductase (2)

NADPH (2)

ABC (2)

cell cycle arrest (2)

Glucokinase (2)

IRE1 (2)

UGT (2)

NMDAR (2)

Fatty Acid Synthase (2)

DNA Alkylation (2)

Hedgehog/Smoothened (2)

FAAH (2)

cAMP (2)

DUB (2)

ATP Citrate Lyase (2)

Beta-Secretase (2)

Histone Acetyltransferase (2)

Decarboxylase (2)

Reverse Transcriptase (2)

Ligand for E3 Ligase (2)

Aromatase (2)

Discoidin Domain Receptor (DDR) (2)

Gap Junction Protein (2)

NADPH-oxidase (2)

NOD (2)

S1P Receptor (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

PROTACs (1)

NPC1L1 (1)

Ligands for Target Protein for PROTAC (1)

YAP (1)

LPL Receptor (1)

LTR (1)

Na+/Ca2+ Exchanger (1)

TOPK (1)

Progesterone Receptor (1)

OCT (1)

Liver X Receptor (1)

Cysteine Protease (1)

Neurotensin Receptor (1)

FXR (1)

iGluR (1)

Myosin (1)

FLAP (1)

Haspin Kinase (1)

Monoamine Transporter (1)

Hexokinase (1)

Guanylate cyclase (1)

Smo (1)

PROTAC Linker (1)

DPP-4 (1)

PAK (1)

Thioredoxin (1)

CXCR (1)

Somatostatin (1)

PAD (1)

Epoxide Hydrolase (1)

ACK (1)

GluR (1)

DNA (1)

BCRP (1)

Acyltransferase (1)

MNK (1)

Aminopeptidase (1)

ASK (1)

hCE (1)

PAI-1 (1)

Pyroptosis (1)

RSV (1)

Hippo pathway (1)

LPA Receptor (1)

CRISPR/Cas9 (1)

Hydroxylase (1)

Adenosine deaminase (1)

DAPK (1)

BMI-1 (1)

Sigma receptor (1)

Thrombin (1)

p97 (1)

ROS Kinase (1)

CFTR (1)

PD-1/PD-L1 (1)

PKM (1)

Kinesin (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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