抗结直肠癌化合物库

Anti-Colorectal Cancer Compound Library

产品编号： L2194

结直肠癌（Colorectal Cancer，CRC)，又称大肠癌，包括结肠癌和直肠癌，是全球范围内致命的恶性肿瘤之一，严重威胁人类健康，近年来其发病率和死亡率均呈上升趋势，并且发病率随着年龄的增加而增加，人口老龄化和不良生活习惯是主要诱因，缺乏运动、肥胖、抽烟也使得患结直肠癌的风险显著增加。结直肠癌的治疗手段包括手术、放疗、化疗和靶向治疗。早期癌症可以通过手术治愈，晚期转移性癌通常选择化疗联合靶向治疗，研究表明，多个信号通路和靶点的失调与结直肠癌有关，如： VEGFR、EGFR、Wnt/β-catenin、p53、TGF-β等 TargetMol 抗结直肠癌化合物库收集了1545 种与结直肠癌相关的化合物，包括已经报道具有结直肠癌治疗作用的化合物，以及靶向结直肠癌相关靶点的化合物，是抗结直肠癌药物研发的良好工具。

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

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产品描述

1545种与结直肠癌相关的化合物，可以用于高通量和高内涵筛选；
部分化合物已上市或已进入临床期；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (277)

Autophagy (210)

PI3K (162)

EGFR (149)

VEGFR (141)

COX (116)

Akt (87)

mTOR (87)

ERK (84)

p38 MAPK (83)

Wnt/beta-catenin (77)

Raf (69)

c-Met/HGFR (66)

AMPK (66)

NF-κB (64)

PDGFR (61)

Ras (58)

GSK-3 (55)

CDK (55)

STAT (52)

TGF-beta/Smad (51)

JNK (48)

c-Kit (45)

Antibacterial (43)

MEK (43)

Src (42)

MAPK (42)

FGFR (40)

Endogenous Metabolite (40)

FLT (39)

DNA-PK (37)

p53 (36)

S6 Kinase (31)

DNA/RNA Synthesis (29)

HER (29)

Parasite (24)

ALK (24)

ATM/ATR (22)

Reactive Oxygen Species (21)

PKC (20)

c-RET (20)

PDK (19)

Gamma-secretase (18)

Antibiotic (18)

Mdm2 (17)

Ferroptosis (17)

Bcr-Abl (17)

E1/E2/E3 Enzyme (17)

JAK (17)

Mitophagy (16)

Caspase (16)

Aurora Kinase (16)

Antifungal (15)

PARP (15)

TNF (15)

PI4K (14)

TAM Receptor (14)

PKA (13)

IGF-1R (13)

Casein Kinase (13)

Dehydrogenase (12)

Rho (12)

Influenza Virus (12)

PPAR (11)

BCL (11)

Trk receptor (11)

c-Fms (11)

P450 (11)

Potassium Channel (11)

HIV Protease (10)

Tyrosine Kinases (10)

IL Receptor (10)

Sirtuin (10)

FAK (10)

Topoisomerase (9)

MMP (9)

Chk (9)

Lipoxygenase (9)

NOS (8)

Phosphatase (8)

Calcium Channel (8)

ROCK (8)

Nucleoside Antimetabolite/Analog (8)

Beta Amyloid (8)

HDAC (8)

Sodium Channel (8)

HCV Protease (7)

PDE (7)

ROS (7)

HSV (7)

PTEN (7)

Prostaglandin Receptor (7)

Epigenetic Reader Domain (6)

Tyrosinase (6)

Carbonic Anhydrase (5)

Estrogen/progestogen Receptor (5)

Tie-2 (5)

Antioxidant (5)

Virus Protease (5)

Aryl Hydrocarbon Receptor (5)

SIK (5)

BTK (5)

Interleukin (5)

HSP (5)

TLR (5)

MNK (5)

Antiviral (5)

Porcupine (5)

Ephrin Receptor (5)

IκB/IKK (5)

SGK (5)

MLK (5)

ASK (5)

MELK (5)

Phospholipase (5)

Microtubule Associated (5)

TOPK (4)

ATPase (4)

Integrin (4)

Estrogen Receptor/ERR (4)

Serine Protease (4)

Adrenergic Receptor (4)

IAP (4)

Drug Metabolite (4)

Glucosidase (4)

PGE Synthase (4)

NO Synthase (4)

Hydroxylase (4)

HIF (4)

AChR (4)

HIF/HIF Prolyl-Hydroxylase (4)

ROS Kinase (4)

DNA Alkylator/Crosslinker (3)

Glutathione Peroxidase (3)

GTPase (3)

Adenosine Receptor (3)

Mitochondrial Metabolism (3)

MRP (3)

CSF-1R (3)

Antifection (3)

DNA Alkylation (3)

P-gp (3)

AChE (3)

KLF (3)

GABA Receptor (3)

PLK (3)

Syk (3)

Chloride channel (2)

Histone Methyltransferase (2)

BACE (2)

DYRK (2)

NADPH (2)

Histamine Receptor (2)

Proton pump (2)

Transferase (2)

TRP/TRPV Channel (2)

IRE1 (2)

RIP kinase (2)

HBV (2)

Pim (2)

Hck (2)

Fatty Acid Synthase (2)

CaMK (2)

Beta-Secretase (2)

SARS-CoV (2)

LRRK2 (2)

transporter (2)

APC (2)

FAAH (2)

CCR (2)

Androgen Receptor (2)

5-HT Receptor (2)

IRAK (2)

Nrf2 (2)

Gap Junction Protein (2)

Discoidin Domain Receptor (DDR) (2)

BMI-1 (2)

Kinesin (2)

PROTACs (1)

DHFR (1)

ROR (1)

Arginase (1)

Reductase (1)

RAAS (1)

Progesterone Receptor (1)

c-Myc (1)

Apelin receptor (1)

NPC1L1 (1)

Dopamine Receptor (1)

Amino Acids and Derivatives (1)

Ligands for Target Protein for PROTAC (1)

YAP (1)

PERK (1)

OCT (1)

Antifolate (1)

Serine/threonin kinase (1)

Glucokinase (1)

PYK2 (1)

Glucocorticoid Receptor (1)

Myosin (1)

UGT (1)

LDL (1)

NMDAR (1)

FXR (1)

Leukotriene Receptor (1)

Neurotensin Receptor (1)

Immunology/Inflammation related (1)

FLAP (1)

MTH1 (1)

Opioid Receptor (1)

Somatostatin (1)

KSP (1)

GluR (1)

cAMP (1)

DNA (1)

DUB (1)

ATP Citrate Lyase (1)

BCRP (1)

ACK (1)

Wee1 (1)

CD73 (1)

Histone Acetyltransferase (1)

Methionine Adenosyltransferase (MAT) (1)

DAPK (1)

cholecystokinin (1)

AhR (1)

hCE (1)

PAI-1 (1)

RSV (1)

GPX (1)

Reverse Transcriptase (1)

Retinoid Receptor (1)

Aromatase (1)

CRISPR/Cas9 (1)

GPR (1)

Cannabinoid Receptor (1)

NADPH-oxidase (1)

DNA Methyltransferase (1)

PD-1/PD-L1 (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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