UBE2K Protein, Human, Recombinant (His & SUMO)

Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.

规格	价格/CNY		数量
10 μg	￥ 220	5日内发货
50 μg	￥ 700	5日内发货
500 μg	￥ 4,740	5日内发货
1 mg	￥ 7,510	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 220

5日内发货

50 μg

￥ 700

5日内发货

500 μg

￥ 4,740

5日内发货

1 mg

￥ 7,510

5日内发货

产品描述

种属	Human
表达系统	E. coli
标签	N-6His,SUMO tag
蛋白编号	P61086
别名	Ubiquitin-Conjugating Enzyme E2-25 kDa, Huntingtin-Interacting Protein 2, Ubiquitin-Conjugating Enzyme E2-25K, HIP-2, Ubiquitin Carrier Protein, HIP2, Ubiquitin-Protein Ligase, Ubiquitin-Conjugating Enzyme E2 K, Ubiquitin-Conjugating Enzyme E2(25K), UBE2K
氨基酸序列	Met1-Asn200
蛋白构建	Recombinant Human Ubiquitin-Conjugating Enzyme E2 K is produced by our E.coli expression system and the target gene encoding Met1-Asn200 is expressed with a 6His, SUMO tag at the N-terminus.
蛋白纯度	Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
分子量	38 KDa, reducing conditions

内毒素	Less than 1 EU/µg as determined by LAL test.
缓冲液	Supplied as a 0.2 μm filtered solution of 20mM PB, 8% Sucrose, 100mM NaCl, 0.05% Tween 80, pH 7.5.
存储	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输方式	The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
研究背景	Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.

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UBE2K Protein, Human, Recombinant (His & SUMO)

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