DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 2,210 | 5日内发货 | ||
500 μg | ¥ 8,900 | 5日内发货 | ||
1 mg | ¥ 14,800 | 5日内发货 |
生物活性 | Immobilized Human Trail, No Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human TRAIL R2, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA. |
产品描述 | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
种属 | Human |
表达系统 | HEK293 |
标签 | C-hFc |
蛋白编号 | O14763-1 |
别名 | TRAIL R2, TNFRSF10B, TRICK2, KILLER, DR5, TRAIL receptor 2, Fas-like protein, TRICKB, ZTNFR9, DR5TRICK2B, CD262, TRICK2A, KILLER/DR5, TRAILR2 |
蛋白构建 | Recombinant Human TRAIL R2/DR5/TNFRSF10B Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Ile56-Glu182.[Accession |O14763-1] |
蛋白纯度 | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
分子量 | The protein has a predicted MW of 41.1 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result. |
内毒素 | Less than 1EU per ug by the LAL method. |
缓冲液 | Lyophilized from 0.22μm filtered solution in 50mM Tris, 100mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization. |
复溶方法 | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储 |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
运输方式 |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
研究背景 | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
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TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc) TRAIL R2 TRAILR 2 TNFRSF10B TRICK2 KILLER CD-262 TRICK 2 DR5 TRAIL receptor 2 CD 262 TRAILR-2 DR-5 Fas-like protein TRICK-2 TRICKB ZTNFR9 DR5TRICK2B ZTNFR 9 CD262 TRICK2A KILLER/DR5 ZTNFR-9 DR 5 TRAILR2 recombinant recombinant-proteins proteins protein