||Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
||Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
||Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and
||Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or in
||Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
||Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
||Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
||VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
||Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
||LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
||Bioymifi is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
||Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical pre
||Pomalidomide inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
||Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
||Disodium clodronate tetrahydrate
||Disodium clodronate tetrahydrate inhibits bone resorption and soft tissue calcification.
||Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol
||GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
||REN-1189 is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.
||Hederacoside D is a bioactive saponins from Hedera helix.
||Prim-O-glucosylcimifugin can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.
||WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
||GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).
||Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
||QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
||Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
||GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
||1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome,liver and kidney functions by reduction of pro-inflammato
||1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressi
||1. Linalool, a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LP
||Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effe
||Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
||R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
||8-O-Acetylshanzhiside methyl ester
||8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppres
||Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
||Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirhizin possesses pote
||Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-i
||Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effect
||Infliximab is a humanized antibody against tumor necrosis factor α (TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.
||Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia，it has a protective and therapeutic effect on hepatocyte injury and shows potent inhibitory acti
||GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
||Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha
||Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccharide-stimulated HUVE
||MALTOTETRAOSE are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atheroscler
||XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders.
||MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
||HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
||GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
||GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
||RIPA-56 is an inhibitor of RIP1
||SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
||GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
||1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitor
||3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibi
||25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have
||25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have
||5,7-Dimethoxyflavanone has anti-inflammatory activity.
||Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce lung adenocarcinoma.
||Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from U
||Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects, probably by interf
||Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovativ
||Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.
||Caulophyllogenin in the inhibition of pro-inflammatory cytokine secretion, including IL-12 p40, IL-6, and TNF-α±, and for prevention and treatment of inflammatory diseases.
||Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent aga
||Homovanillyl alcohol displays high scavenging activities, it protects red blood cells from hemolysis in a dose-dependent manner. Homovanillyl alcohol has protective effect on cardi
||Lucidenic acid D2
||Lucidenic acid D2 is a nartural product from G. lucidum AF.
||Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of
||Mogroside IIIe has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. It al
||Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
||Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration o
||Physcion 8-O-beta-D-monoglucoside has anti-inflammatory activity, it can inhibit TNF-α±-induced cytotoxicity and apoptosis in L929 cells via TNF-R1.
||Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulation of the CDK inhib
||Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage
||Procurcumenol is an inhibitor of Nitric Oxide. Procurcumenol and epicurcumenol have inhibitory effects on release of tumor necrosis factor-a (TNF-a).
||Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages.
||Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
||Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocyt
||Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α±, which cons
||Taurocholic acid feeding shows cytoprotective effects on the biliary tree after adrenergic denervation of the liver; taurocholic acid feeding prevents tumor necrosis factor-alpha-i
||Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
||Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
||3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression
||5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml
||5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB
||Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
||Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
||Cleomiscosin A has antioxidant activity, it could be beneficial in preventing LDL oxidation in atherosclerotic lesions, it shows inhibitory activity to TNF-α± secretion of the mo
||Dihydrocucurbitacin B has anti-cancer activity, it reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of the actin cytoskele
||Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity, they prot
||Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
||Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
||Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic for treatment of s
||Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation
||Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or stroke via the modulatio
||N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving vascular distensibility and in reducing
||Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. Neocurdione shows a protective effect against D-GalN/tumor necrosis factor-alpha-i
||Neoisoastilbin may have antioxidant and anti-inflammatory activities.
||Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
||Licochalcone E is a potential LXRβ agonist.
||Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
||Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
||Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 diabetes activitie
||2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and make a contribution
||3,3'-Di-O-methylellagic acid reveals moderate antibacterial activity, it also shows strong DPPH radical scavenging activities with SC50 of 123.3 ug/mL. It has a lower capacity of s
||Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
||Isoscoparin has antioxidant, and anti-adipogenic effects, it may be a potential therapeutic agent for the prevention and treatment of obesity. Isoscoparin can significantly inhibit
||Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process.
||Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulatio
||Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals. Sugiol's efficacy
||Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
||Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is a tricyclic derivative.
||Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can pote
||RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM fo
||Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α release by lipopolysac
||GSK3145095 is an inhibitor of RIP1 kinase (IC50: 6.3 nM).
||CDC801 is a potent and orally active inhibitor of PDE4 and TNF-α (IC50: 1.1 μM and 2.5 μM).
||GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean Kiapp values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively.
||GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, is inhibits kinase activity with an IC50 of 6.5 nM,which binds RIP3 kinase domain with an IC50 of
||GSK2593074A is a necroptosis inhibitor with dual targeting ability to both RIP1 and RIP3.
||GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, and inhibits kinase activity with an IC50 of 0.3 nM. which binds RIP3 kinase domain with an IC50 of
||TNF-α-IN-1 is an inhibitor of TNF-α.
||cRIPGBM is a proapoptotic derivative of RIPGBM and a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to RIPK2 (EC50: 68 nM in GBM-1 cells).
||RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).
||Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth.
||Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.
||Karanjin is a potent Volume-regulated anion channels(VRACs) current inhibitor, the VRAC inhibition might be responsible for its anti-angiogenic effects. Karanjin possesses antioxid
||Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulat
||Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first time in medicinal p
||Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.
||Dryocrassin ABBA can significantly suppress tumor growth, without major side effects, it may induce apoptosis in human hepatocellular carcinoma cells through a caspase-mediated mit
||Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-
||Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflamma
||Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions, it also exhibits immunosuppressive ef
||Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic p
||Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal path
||1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
||11-Hydroxytephrosin inhibits NF-kappaB activity.
||2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidati
||3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
||Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.
||5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) s
||6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function, it can be a poten
||7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated E
||7-O-Methylmorroniside exhibits anti-inflammatory activity.
||8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-ÎºB activity with the IC(50) value of 1.9 uM.
||(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a
||Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38
||Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects
||Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
||Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
||Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE-30 oesophageal squ
||Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidatio
||Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptio
||Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be furth
||Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits canc
||Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO-1 induction is res
||Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS
||Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.
||Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC ar
||cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
||Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating imm
||Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4
||Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rheumatoid arthritis
||De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO productio
||Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neur
||Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO pr
||Dihydrodehydrodiconiferyl alcohol exhibits in vitro cytotoxicity in various cancer cell lines. It may be useful candidates for developing therapeutic agents for the prevention and
||Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory
||Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α
||Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflamma
||Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. It can s
||Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Fl
||Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines.
||Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also h
||Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
||Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it mig
||Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammatory response in BV2
||Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging
||Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells. Heliangin has a
||Hydrangenol 8-O-glucoside may have anti-inflammary activity.
||Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.
||Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil de
||Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and
||Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting HSC activation, poss
||Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic infl
||Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages.
||Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron transport chain.
||Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays poten
||Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from R
||Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associa
||Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replicati
||Methylnissolin is a natural product from A. membranaceus.
||Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization of Moracin may open
||Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune
||Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji
||Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the phosphorylation o
||Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated by MKP-5/NF-ÎºB p
||Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, t
||Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in a mouse model and
||Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Physalin
||Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro
||Samidin has anti-inflammatory properties through suppression of NF-ÎºB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
||Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
||Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by
||Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactiva
||Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Ta
||Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312µM and higher. I
||Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal
||Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinok
||Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β production in THP-1 cel
||Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS prot
||Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of
||(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.