TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product Name	CAS No.	Purity
T2434	LY 303511 化合物LY 303511	154447-38-8	99.91%
T2434	LY303511 是 LY294002 的结构类似物，可增强 SHEP-1 神经母细胞瘤细胞的TRAIL 敏感性，还可逆地阻断 MIN6 胰岛瘤细胞中的K+电流，IC50为64.6±9.1 μM。
T30531	BMS-561392 化合物BMS-561392	611227-74-8	99.16%
T30531	BMS-561392 (DPC333)是一种肿瘤坏死因子-α(TNF-α)转化酶抑制剂。
TN2180	Sappanchalcone 化合物Sappanchalcone	94344-54-4	97.00%
TN2180	Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN4592	Murrangatin 化合物 TN4592	37126-91-3	98%
TN4592	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TN3635	Chlojaponilactone B 化合物 TN3635	1449382-91-5	98%
TN3635	Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TN4938	Samidin 化合物 TN4938	477-33-8	98%
TN4938	Samidin has anti-inflammatory properties through suppression of NF-ÎºB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
T5S0313	Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside 甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷	199796-12-8	98%
T5S0313	Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells again...
TN5164	Trans-Hinokiresinol 化合物 TN5164	17676-24-3	98%
TN5164	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
TN1681	Gentianine 秦艽甲素	439-89-4	98%
TN1681	Gentianine 是一种有效的 Swertiamarin 衍生物，具有抗糖尿病、抗精神病、抗炎、降血压、利尿等作用，具有被开发成一种安全的降压药物的潜力。
TN4038	Eupatolide 泽兰内酯	6750-25-0	98%
TN4038	Eupatolide 是从 Inula japonica 的花中分离出来的，具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
TN3587	Capillarisin 化合物 TN3587	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN5147	Tilifodiolide 化合物 TN5147	126724-95-6	98%
TN5147	Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
TMA1777	Hydrangenol 8-O-glucoside 化合物 TMA1777	67600-94-6	98%
TMA1777	Hydrangenol 8-O-glucoside may have anti-inflammary activity.
TN3410	Anatabine 化合物 TN3410	581-49-7	98%
TN3410	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN3452	Arteannuin M 化合物 TN3452	207446-90-0	98%
TN3452	Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN4429	Leucodin 化合物 TN4429	17946-87-1	98%
TN4429	Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosamini...
TN1890	Lupeol acetate 乙酸羽扇醇酯	1617-68-1	98%
TN1890	Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the co...
TN5278	Zederone 化合物 TN5278	7727-79-9	98%
TN5278	Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TN2974	3-O-Methylquercetin tetraacetate 化合物 TN2974	1486-69-7	98%
TN2974	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
TN1764	Incensole acetate 因香酚乙酸酯	34701-53-6	98%
TN1764	Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.