Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 820 | 5日内发货 | ||
50 μg | ¥ 2,480 | 5日内发货 | ||
500 μg | ¥ 13,200 | 5日内发货 | ||
1 mg | ¥ 18,900 | 5日内发货 |
产品描述 | Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7. |
种属 | Human |
表达系统 | E. coli |
标签 | None |
蛋白编号 | P42224 |
别名 | Transcription Factor ISGF-3 Components p91/p84, STAT1, Signal Transducer and Activator of Transcription 1-Alpha/Beta, Signal Transducer and Activator of Transcription 1-α/β, Signal Transducer and Activator of Transcription 1-α/Beta |
氨基酸序列 | Met1-Val712 |
蛋白构建 | Recombinant Human Signal Transducer And Activator Of Transcription 1 is produced by our E.coli expression system and the target gene encoding Met1-Val712 is expressed. |
蛋白纯度 | Greater than 68% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 85 KDa, reducing conditions |
内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 0.02% Tween 80, 5% Sucrose, 4% Mannitol, pH 7.4. |
复溶方法 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
存储 |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
运输方式 |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
研究背景 | Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7. |
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STAT1 Protein, Human, Recombinant Transcription Factor ISGF-3 Components p91/p84 STAT-1 STAT1 Signal Transducer and Activator of Transcription 1-Alpha/Beta STAT 1 Signal Transducer and Activator of Transcription 1-α/β Signal Transducer and Activator of Transcription 1-α/Beta recombinant recombinant-proteins proteins protein