Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vinaxanthone (SM-345431) 是一种从青霉菌中提取的小分子化合物,是一种具有选择性和有效性的 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂,抑制semaphorin3A 和 FabI。Vinaxanthone 具有抗菌活性,阻止细胞内脂肪酸合成,抑制金黄色葡萄球菌的生长。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 3,270 | 现货 | ||
5 mg | ¥ 8,250 | 现货 | ||
10 mg | ¥ 10,900 | 现货 | ||
25 mg | ¥ 15,800 | 现货 | ||
50 mg | ¥ 19,800 | 现货 |
产品描述 | Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that is a selective and potent semaphorin3A, phospholipase C (PLC), and FabI inhibitor, inhibiting semaphorin3A and FabI.Vinaxanthone exhibits antimicrobial activity, blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus. |
靶点活性 | PA:9.3 μM (mouse colon 26 adenocarcinoma), PA:44 μM (NIH3T3 cell), PA:5.4 μM (Rat brain) |
体外活性 | Vinaxanthone exhibits selective inhibitory activity against phospholipase C (PLC) in rat brain, mouse colon 26 adenocarcinoma, and mouse fibroblast NIH3T3 cells, with IC50 values of 5.4, 9.3, and 44 μM, respectively.At a concentration of 0.1 mg/mL for 24 hours, Vinaxanthone enhances peripheral nerve regeneration and induces limited neovascularization in the cornea[1].At a concentration of 0.5 μM for 20 minutes, Vinaxanthone may protect against Doxorubicin-induced apoptosis in foot cells[3].In the range of 0.1-1 μM for 24 hours, Vinaxanthone improves the changes in renal tubular cell characteristics induced by TGF-β1[2]. |
体内活性 | Vinaxanthone (SM-345431), administered by subconjunctival injection at a concentration of 0.1 mg/mL every two days for 3 weeks, accelerates peripheral nerve regeneration and functional recovery in a mouse corneal transplantation model[1].Vinaxanthone (SEMA3A-I), given by intraperitoneal injection at a dose of 20 µg, protects against podocyte injury induced by Adriamycin in a mouse model through an anti-apoptotic mechanism[3]. |
别名 | SM-345431 |
分子量 | 576.42 |
分子式 | C28H16O14 |
CAS No. | 133293-89-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (138.79 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7348 mL | 8.6742 mL | 17.3485 mL | 43.3712 mL |
5 mM | 0.347 mL | 1.7348 mL | 3.4697 mL | 8.6742 mL | |
10 mM | 0.1735 mL | 0.8674 mL | 1.7348 mL | 4.3371 mL | |
20 mM | 0.0867 mL | 0.4337 mL | 0.8674 mL | 2.1686 mL | |
50 mM | 0.0347 mL | 0.1735 mL | 0.347 mL | 0.8674 mL | |
100 mM | 0.0173 mL | 0.0867 mL | 0.1735 mL | 0.4337 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Vinaxanthone 133293-89-7 Metabolism Microbiology/Virology Phospholipase Antibacterial SM345431 SM-345431 SM 345431 Inhibitor inhibitor inhibit