store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Teglarinad chloride (GMX-1777 chloride) 是一种有效的 NAMPT 的抑制剂,是 GMX1778 的前体。Teglarinad chloride 具有抗肿瘤活性,通过干扰 DNA 修复和抑制血管生成来发挥作用。
产品描述 | Teglarinad chloride (GMX-1777 chloride) is a potent inhibitor of NAMPT, the precursor of GMX1778.Teglarinad chloride has antitumor activity and acts by interfering with DNA repair and inhibiting angiogenesis. |
体内活性 | In the IM-9 model, small-cell lung cancer (SHP-77) model, and colon carcinoma (HCT-116) model, GMX1777 (75 mg/kg; 24 h intravenous infusion) induces tumor regression[2].For both FaDu and C666-1 tumors in vivo, GMX1777 (50-100 mg/kg/day, intramuscular for 5 days), with or without local tumor radiotherapy, proves to be effective[1].Upon intravenous infusion (25-400 mg/kg; 24 h), GMX1777 is rapidly converted to GMX1778 in the plasma of mice, with a half-life of GMX1777 less than 0.7 h[1]. |
别名 | GMX 1777 chloride, EB1627, GMX1777, GMX1777 chloride, GMX 1777, GMX-1777 chloride, EB-1627, EB-1627 chloride, EB1627 chloride |
分子量 | 672.6 |
分子式 | C30H43Cl2N5O8 |
CAS No. | 432037-57-5 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Teglarinad chloride 432037-57-5 Metabolism NAMPT GMX 1777 chloride Teglarinad Chloride EB1627 GMX1777 GMX1777 chloride GMX 1777 GMX1777 Chloride GMX-1777 chloride EB-1627 GMX-1777 EB-1627 chloride GMX 1777 Chloride GMX-1777 Chloride EB 1627 EB1627 chloride Inhibitor inhibitor inhibit