Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ERK-IN-3 (ASN007 free base) 是一种有效的口服活性 ERK 抑制剂,以低 IC50 值抑制 ERK1/2,可用于研究由 RAS 突变驱动的癌症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 473 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,980 | 现货 | ||
25 mg | ¥ 4,560 | 现货 | ||
50 mg | ¥ 7,880 | 现货 | ||
100 mg | ¥ 13,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,280 | 现货 |
产品描述 | ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations. |
体外活性 | ERK-IN-3 shows single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines.ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates like RSK1, FRA1, and Elk1 in various cell lines. |
体内活性 | ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice that was well tolerated at efficacious doses. |
别名 | ASN007 free base |
分子量 | 473.93 |
分子式 | C22H25ClFN7O2 |
CAS No. | 2055597-12-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (527.50 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.11 mL | 10.5501 mL | 21.1002 mL | 52.7504 mL |
5 mM | 0.422 mL | 2.11 mL | 4.22 mL | 10.5501 mL | |
10 mM | 0.211 mL | 1.055 mL | 2.11 mL | 5.275 mL | |
20 mM | 0.1055 mL | 0.5275 mL | 1.055 mL | 2.6375 mL | |
50 mM | 0.0422 mL | 0.211 mL | 0.422 mL | 1.055 mL | |
100 mM | 0.0211 mL | 0.1055 mL | 0.211 mL | 0.5275 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ERK-IN-3 2055597-12-9 MAPK ERK ERK1/2 inhibit Inhibitor ASN 007 ERK IN 3 RAS ASN-007 Extracellular signal regulated kinases cancer ASN007 free base ASN007 ERKIN3 inhibitor