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BN82002 hydrochloride

产品编号 T38447 CAS 1049740-43-3

BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. Additionally, BN82002 hydrochloride exhibits approximately 20-fold greater selectivity over CD45 tyrosine phosphatase.

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BN82002 hydrochloride Chemical Structure

BN82002 hydrochloride, CAS 1049740-43-3

规格	价格/CNY	货期
2 mg	￥ 554	5日内发货
5 mg	￥ 913	5日内发货
10 mg	￥ 1,410	5日内发货
1 mL * 10 mM (in DMSO)	￥ 983	5日内发货

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BN82002 hydrochloride 的其他形式现货产品:

BN82002

其他形式的 BN82002 hydrochloride:

BN82002
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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. Additionally, BN82002 hydrochloride exhibits approximately 20-fold greater selectivity over CD45 tyrosine phosphatase.
靶点活性	CDC25B2:3.9 μM (IC50), CDC25A:2.4 μM (IC50), CDC25B3:6.3 μM (IC50), CDC25C:5.4 μM (IC50), CDC25C-cat:4.6 μM (IC50)
体外活性	The effect of BN82002 on cell proliferation is evaluated in vitro on several human tumor cell lines. Menadione, which has been reported to inhibit cell proliferation, is used as a control. All of the examined cell lines are sensitive to BN82002 and Menadione in a concentration-dependent manner in the low micromolar range. The most sensitive is the pancreatic cancer cell line MIA PaCa-2 with an IC 50 of 7.2 μM, and the less sensitive cell line is the colon cancer HT-29 with an IC 50 of 32.6 μM. The range of activity is very similar to the one observed with menadione (5-15 μM). It is also showed that 50 μM BN82002 is a concentration that fully inhibits cell proliferation, the cell cycle distribution is only modestly affected with a slight decrease in S phase and an increase in cells containing both a G1 and a G2 DNA content, suggesting that the cells treated with BN82002 are arrested at various stages of the cell cycle[1].

分子量	395.88
分子式	C19H26ClN3O4
CAS No.	1049740-43-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Brezak MC, et al. A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer Res. 2004 May 1;64(9):3320-5.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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