| T0945 | Cyclosporin A | Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycopr |
| T1927 | CCT007093 | CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM). |
| T2481 | Ascomycin | Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. |
| T3544 | SHP099 hydrochloride | SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor. |
| T4340 | SPI 112 | SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinet |
| T6459 | Cyclosporine | Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. |
| T6521 | GSK2830371 | GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM. |
| T6911 | NSC87877 | NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and |
| T4256 | PTP1B-IN-2 | PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM). |
| T4308 | F1063-0967 | F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM. |
| T4491 | LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) | LMPTP INHIBITOR 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. |
| T7084 | PTP Inhibitor I | PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phospha |
| T4671 | CDC25 Phosphatase Inhibitor I | BN82002 is a synthetic inhibitor of CDC25 phophatases |
| T5708 | LUPENONE | Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 val |
| T5878 | β-Glycerol phosphate disodium salt pentahydrate | β-Glycerol phosphate disodium salt pentahydrate is a protein phosphatase inhibitor. |
| T7381 | TCS 401 | TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM) |
| T7356 | PTP1B-IN-1 | PTP1B-IN-1 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50 : 1.6 mM) |
| T7541 | PTP Inhibitor II | PTP inhibitor II is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing ph |
| T7704 | KY-226 | KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,) |
| T7078 | NSC 95397 | NSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively). |
| TQ0032 | Rosiptor | Rosiptor (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects. |
| T7820 | Raphin1 | Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). |
| T7028 | LICOCHALCONEC | Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, an |
| TN1053 | Aloe-emodin-8-O-beta-D-glucopyranoside | Aloe-emodin-8-O-beta-D-glucopyranoside shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro. |
| T12577 | PTP1B-IN-3 | PTP1B-IN-3 is a potent and selective inhibitor of PTP1B (PTP1B and TCPTP with IC50s of 120 nM and 120 nM , respectively). |
| T12578 | PTP1B-IN-8 | PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B). |
| T14037 | 3α-Aminocholestane | 3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM. |
| T13176 | TNO155 | TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplast |
| T15166 | DPM-1001 | DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property. |
| T10060L | DT-061 | DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. |
| T15243 | Ertiprotafib | Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ). |
| T12934 | SMAP-2 | SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhibits the growth of |
| T13013 | Sodium stibogluconate | Sodium stibogluconate is a potent protein tyrosine phosphatase inhibitor. |
| T11687 | Itacitinib adipate | Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelofibrosis. |
| T11735 | K-Ras G12C-IN-1 | K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| T8519 | Raphin1 acetate | Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor. |
| T8478 | SC-43 | SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects. |
| T3930 | Taraxeryl acetate | Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol |
| TCS1372 | Atraric acid | Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of prostatic diseases. It |
| TN2887 | 3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid | (24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM. |
| TN2913 | 3-Acetoxy-11-ursen-28,13-olide | 3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate an |
| TN3335 | Abyssinone V | Abyssinone V is a protein tyrosine phosphatase-1B (PTP1B) inhibitor, it inhibited PTP1B activity, with IC50 values ranging from 14.8 +/- 1.1 to 39.7 +/- 2.5 microM. |
| TN3505 | Beta-Peltoboykinolic acid | Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cytotoxic activity. |
| TN3525 | Boehmenan | (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive mann |
| TN4064 | Flavoglaucin | Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Fl |
| TN4551 | Methyl orsellinate | Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa cr |
| T10486 | BCI | BCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5. |
| T16350 | NSC-87877 | NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phos |
| T20879 | Tacrolimus hydrate | Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits cal |
| T20879 | Tacrolimus hydrate | Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits cal |
