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T0945 Cyclosporin A Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycopr
T1927 CCT007093 CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM).
T2481 Ascomycin Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
T3544 SHP099 hydrochloride SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor.
T4340 SPI 112 SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinet
T6459 Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
T6521 GSK2830371 GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.
T6911 NSC87877 NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and
T4256 PTP1B-IN-2 PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
T4308 F1063-0967 F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
T4491 LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) LMPTP INHIBITOR 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
T7084 PTP Inhibitor I PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phospha
T4671 CDC25 Phosphatase Inhibitor I BN82002 is a synthetic inhibitor of CDC25 phophatases
T5708 LUPENONE Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 val
T5878 β-Glycerol phosphate disodium salt pentahydrate β-Glycerol phosphate disodium salt pentahydrate is a protein phosphatase inhibitor.
T7381 TCS 401 TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
T7356 PTP1B-IN-1 PTP1B-IN-1 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50 : 1.6 mM)
T7541 PTP Inhibitor II PTP inhibitor II is an  inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing ph
T7704 KY-226 KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)
T7078 NSC 95397 NSC 95397 is a  potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively).
TQ0032 Rosiptor Rosiptor (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.
T7820 Raphin1 Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
T7028 LICOCHALCONEC Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, an
TN1053 Aloe-emodin-8-O-beta-D-glucopyranoside Aloe-emodin-8-O-beta-D-glucopyranoside shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
T12577 PTP1B-IN-3 PTP1B-IN-3 is a potent and selective inhibitor of PTP1B (PTP1B and TCPTP with IC50s of 120 nM and 120 nM , respectively).
T12578 PTP1B-IN-8 PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B).
T14037 3α-Aminocholestane 3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
T13176 TNO155 TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplast
T15166 DPM-1001 DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.
T10060L DT-061 DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
T15243 Ertiprotafib Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ).
T12934 SMAP-2 SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhibits the growth of
T13013 Sodium stibogluconate Sodium stibogluconate is a potent protein tyrosine phosphatase inhibitor.
T11687 Itacitinib adipate Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelofibrosis.
T11735 K-Ras G12C-IN-1 K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
T8519 Raphin1 acetate Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.
T8478 SC-43 SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.
T3930 Taraxeryl acetate Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol
TCS1372 Atraric acid Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of prostatic diseases. It
TN2887 3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid (24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
TN2913 3-Acetoxy-11-ursen-28,13-olide 3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate an
TN3335 Abyssinone V Abyssinone V is a protein tyrosine phosphatase-1B (PTP1B) inhibitor, it inhibited PTP1B activity, with IC50 values ranging from 14.8 +/- 1.1 to 39.7 +/- 2.5 microM.
TN3505 Beta-Peltoboykinolic acid Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cytotoxic activity.
TN3525 Boehmenan (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive mann
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Fl
TN4551 Methyl orsellinate Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa cr
T10486 BCI BCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.
T16350 NSC-87877 NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phos
T20879 Tacrolimus hydrate Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits cal
T20879 Tacrolimus hydrate Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits cal
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