Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 2,330 | 5日内发货 | ||
50 mg | ¥ 12,500 | 5日内发货 | ||
100 mg | ¥ 17,500 | 5日内发货 |
产品描述 | Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity. |
体外活性 | Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC)[1]. |
体内活性 | Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1]. |
别名 | KF-89617, LY-2523355 |
分子量 | 511.7 |
分子式 | C23H37N5O4S2 |
CAS No. | 910634-41-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (97.71 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9543 mL | 9.7714 mL | 19.5427 mL | 48.8568 mL |
5 mM | 0.3909 mL | 1.9543 mL | 3.9085 mL | 9.7714 mL | |
10 mM | 0.1954 mL | 0.9771 mL | 1.9543 mL | 4.8857 mL | |
20 mM | 0.0977 mL | 0.4886 mL | 0.9771 mL | 2.4428 mL | |
50 mM | 0.0391 mL | 0.1954 mL | 0.3909 mL | 0.9771 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Litronesib 910634-41-2 Cytoskeletal Signaling Kinesin KF-89617 KF89617 LY-2523355 LY 2523355 LY2523355 KF 89617 Inhibitor inhibitor inhibit