Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gliotoxin 是一种次生代谢产物,由A. fumigatus 分泌,可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性,从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度,调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 997 | 35日内发货 | ||
5 mg | ¥ 4,420 | 35日内发货 | ||
10 mg | ¥ 7,380 | 35日内发货 |
产品描述 | Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. |
靶点活性 | Mycobacterium tuberculosis:<0.03 μM(MIC50) |
体外活性 | The structures of these compounds (1-12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated[1] |
分子量 | 326.39 |
分子式 | C13H14N2O4S2 |
CAS No. | 67-99-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform: 10 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Gliotoxin 67-99-2 Apoptosis Cytoskeletal Signaling Immunology/Inflammation Microbiology/Virology Neuroscience NF-Κb Stem Cells Tyrosine Kinase/Adaptors NF-κB Wnt/beta-catenin COX PKA Antibacterial Antifection Aspergillin Fungal Inhibitor Bacterial inhibit Protein kinase A Nuclear factor-κB Nuclear factor-kappaB Antibiotic inhibitor