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anti_parkinson's_disease_compound_library
/library/anti_parkinson's_disease_compound_library
抗帕金森病化合物库
Anti-Parkinson's Disease Compound Library
产品编号: L9830

帕金森病(Parkinson's disease,PD)是常见的慢性神经退行性运动障碍,影响着全球1%的70岁以上的人群。其临床表现主要包括静止性震颤、运动迟缓、肌强直和姿势步态障碍,同时患者可伴有抑郁、便秘和睡眠障碍等非运动症状。帕金森病的确切病因至今未明。遗传因素、环境因素、年龄老化、氧化应激等均可能参与PD 多巴胺能神经元的变性死亡过程。目前为止没有药物可以治疗这种疾病,而现有的治疗方法仅仅在于处理其症状,但是不能延缓其进展。

根据抗PD 药物作用靶点可以分为多巴胺替代药物、多巴胺释放剂、单胺氧化酶-B(MAO-B)抑制剂、儿茶酚-O-甲基转移酶(COMT)抑制剂、多巴胺受体激动剂和辅助治疗药物(如抗胆碱能药物、抗组胺药物和抗抑郁药等)。

TargetMol 抗帕金森病化合物库收集了857 种具有抗帕金森病活性的化合物及靶向帕金森病主要靶点的化合物,可用于相关的药物开发和药理研究。

陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
产品规格
  • 857种帕金森病相关的化合物集合,可用于高通量和高内涵筛选;
  • 靶点含Dopamine Receptor, COMT, MAO-B, 5-HT Receptor等;
  • 部分化合物已经得到FDA批准上市; 
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。
化合物库定制
我们的化合物库可以灵活定制!了解更多
化合物库咨询
化合物库组成
5-HT Receptor (262)
Dopamine Receptor (177)
AChR (135)
GABA Receptor (102)
Opioid Receptor (68)
Histamine Receptor (62)
Adrenergic Receptor (60)
Apoptosis (55)
NMDAR (53)
Autophagy (51)
iGluR (43)
Endogenous Metabolite (33)
Reactive Oxygen Species (31)
GluR (29)
Serotonin Transporter (23)
Norepinephrine (21)
LRRK2 (18)
Adenosine Receptor (17)
MAO (17)
Potassium Channel (17)
Calcium Channel (16)
Antibacterial (16)
Sodium Channel (14)
P450 (13)
Monoamine Oxidase (11)
Transferase (10)
Influenza Virus (10)
Bcr-Abl (9)
AChE (9)
Parasite (8)
Mitochondrial Metabolism (8)
NF-κB (7)
ROS (6)
HIV Protease (5)
Src (5)
Dehydrogenase (5)
Antifungal (5)
Mitophagy (5)
COX (5)
Beta Amyloid (5)
Histone Methyltransferase (4)
Caspase (4)
TRP/TRPV Channel (4)
PDE (4)
BCL (4)
Aurora Kinase (4)
CaMK (4)
FLT (4)
Sigma receptor (4)
NO Synthase (4)
NOS (3)
Ferroptosis (3)
PI3K (3)
Virus Protease (3)
PARP (3)
Gamma-secretase (3)
Drug Metabolite (3)
JAK (3)
IL Receptor (3)
P-gp (3)
Trk receptor (3)
IκB/IKK (3)
TNF (3)
Antibiotic (3)
HER (3)
Chloride channel (2)
Carbonic Anhydrase (2)
Estrogen/progestogen Receptor (2)
DYRK (2)
RAAS (2)
JNK (2)
CDK (2)
Monoamine Transporter (2)
MMP (2)
Interleukin (2)
DNA/RNA Synthesis (2)
Prostaglandin Receptor (2)
transporter (2)
HDAC (2)
Phospholipase (2)
FGFR (2)
Cannabinoid Receptor (2)
Syk (2)
Anti-infection (2)
c-Kit (2)
p53 (2)
Transaminase (1)
ROR (1)
HCV Protease (1)
Amino Acids and Derivatives (1)
p38 MAPK (1)
c-Met/HGFR (1)
Na+/Ca2+ Exchanger (1)
IFNAR (1)
Arrestin (1)
RAR/RXR  (1)
NADPH (1)
Histone Demethylase (1)
Progesterone Receptor (1)
Melatonin Receptor (1)
ABC (1)
PKA (1)
MRP (1)
HBV (1)
PPAR (1)
Wnt/beta-catenin (1)
Rho (1)
VEGFR (1)
ROCK (1)
Aryl Hydrocarbon Receptor (1)
Glucocorticoid Receptor (1)
IAP (1)
Annexin A (1)
E1/E2/E3 Enzyme (1)
GRK (1)
P2X Receptor (1)
Glucosidase (1)
Hexokinase (1)
DNA Alkylation (1)
FAAH (1)
Stearoyl-CoA Desaturase (SCD) (1)
HSV (1)
CCR (1)
Epigenetic Reader Domain (1)
Lipoxygenase (1)
IGF-1R (1)
DUB (1)
mTOR (1)
Androgen Receptor (1)
TGF-beta/Smad (1)
SGLT (1)
MAPK (1)
Acyltransferase (1)
OAT (1)
HSP (1)
STING (1)
Decarboxylase (1)
Nrf2 (1)
GluCls (1)
RSV (1)
Neprilysin (1)
GST (1)
STAT (1)
Retinoid Receptor (1)
CRISPR/Cas9 (1)
GPR (1)
Hydroxylase (1)
MEK (1)
SGK (1)
NOD (1)
Ras (1)
HMG-CoA Reductase (1)
S6 Kinase (1)
Microtubule Associated (1)
Tyrosinase (1)
NOD-like Receptor (NLR) (1)
MLK (1)
Imidazoline Receptor (1)
化合物库信息示例
Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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