T2301 |
SB202190HOT |
SB 202190 is a selective and cell-permeable inhibitor of p38 MAPK (IC50s: 50/100 nM for p38α/p38β).
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T1764 |
SB203580HOT |
SB 203580 is a p38 MAPK inhibitor (IC50: 0.3-0.5 μM). It shows more than 100-fold selectivity over PKB, LCK, and GSK-3β.
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T6277 |
DoramapimodHOT |
Doramapimod is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.
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T9581 |
ARRY-797 |
ARRY-797 is a potent and selective p38α inhibitor and inhibits LPS-Induced IL-6.
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T5494 |
MW-150 |
MW-150 is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.
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T4646 |
TA02 |
TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.
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T6S0525 |
Farrerol |
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
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T3S0737 |
Flavokawain A |
1. Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-mu...
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T5S0045 |
Isofraxidin |
1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
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T5S0168 |
Atractylenolide II |
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK ...
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T4S2063 |
Tetrahydrocoptisine |
1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
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T5S2283 |
Sesamolin |
1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 ac...
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T4S1419 |
Praeruptorin A |
1. Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praer...
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T4597 |
UM164 |
UM-164 is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164 also potently inhibits p38α and p38β.
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T5172 |
AZ304 |
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
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T5393 |
CK1-IN-1 |
CK1-IN-1, compound 1c reported in patent WO2015119579A1, is a casein kinase 1 (CK1) inhibitor. It has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MA...
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T7162 |
R1487 (Hydrochloride) |
R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
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T5814 |
Aurantiamide |
Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Auran...
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T7276 |
SD 0006 |
SD 0006 is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.
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T6S1572 |
Sauchinone |
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation o...
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T7367 |
Acumapimod |
Acumapimod is an orally active inhibitor of p38α MAPK (IC50 <1 μM).
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T7661 |
SD 169 |
SD 169 is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.
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T7667 |
R1487 |
R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.
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TN1117 |
Veraguensin |
Veraguensin shows activity against trypomastigote T. cruzi., it shows high antileishmanial activity.
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TN1211 |
2-Hydroxy-3-methylanthraquinone |
2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activ...
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TN1347 |
8-Prenylkaempferol |
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
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TN1362 |
Afzelin |
Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protec...
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TN1448 |
(-)-Bornyl acetate |
(-)-Bornyl acetate is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity. (-)-Bornyl ...
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TN1490 |
Chrysoeriol |
Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilato...
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TN1751 |
Hydroxycitric acid |
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
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T4645 |
TA01 |
TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.
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T7030 |
Anemarsaponin B |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity...
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T4575 |
Chromium picolinate |
Chromium picolinate causes DNA damage and mutation. It is an activator of p38.
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T2277 |
Losmapimod |
Losmapimod (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).
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T6732 |
WYE687 |
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(...
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T6130 |
Skepinone-L |
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
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T2432 |
PD 169316 |
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
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T3025 |
Asiaticoside |
Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burn...
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T6976 |
SB239063 |
SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
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T6089 |
Neflamapimod |
VX-745, a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.
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T6150 |
TAK715 |
TAK-715 is a p38 MAPK inhibitor for p38α.
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T2118 |
SC514 |
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
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T6167 |
SU9516 |
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
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|
T6927 |
Pamapimod |
Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 v...
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|
T2827 |
Asiatic acid |
Asiatic acid is the aglycone of asiaticoside used in wound healing with antioxidant, anti-inflammatory, and neuroprotective properties.
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|
T1974 |
PH797804 |
PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.
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TN1882 |
Lucidenic acid D2 |
Lucidenic acid D2 is a nartural product from G. lucidum AF.
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|
T6789 |
BMS582949 |
BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM, inhibiting both p38 kinase activity and activa...
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|
T6677 |
Sophocarpine |
Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting osteoclast forma...
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|
T2367 |
SKF86002 |
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
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T2513 |
VX702 |
VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytok...
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|
T3390 |
Obacunone |
Obacunone has cytotoxicity in androgen-dependent human prostate Y cells. Obacunone exerts an antivirulence effect on S. Typhimurium and may serve as a lead compo...
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|
T1922 |
Pseudolaric Acid B |
Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
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T6047 |
Ralimetinib Mesylate |
Ralimetinib Mesylate is the dimesylate salt form of LY2228820, a tri-substituted imidazole derivative and orally available, p38 mitogen-activated protein kinase ...
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|
T3462 |
BMS-582949 HCl |
The BMS-582949 hydrochloride is a highly specific p38α MAPK inhibitor (IC50: 13 nM).
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T6380 |
AMG900 |
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases ...
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|
T6934 |
Pexmetinib |
Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.
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T4078 |
SB242235 |
SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.
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|
T4034 |
Solamargine |
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth...
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|
TN1879 |
Lucidenic acid A |
Lucidenic acid-A and -F are modulators of JNK and p38, respectively, they enhance LPS-induced immune responses in monocytic THP-1 cells possibly via the modulati...
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|
TN1916 |
Matairesinol |
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducib...
|
|
T9218 |
Andrograpanin |
Andrograpanin is a bioactive compound from Andrographis paniculata. Andrograpanin has anti-inflammatory and anti-infectious properties.
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|
TN4271 |
Isochamaejasmine |
Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the ...
|
|
TN3209 |
7,3',4'-Trihydroxyflavone |
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
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|
TN3364 |
Agrimonolide |
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
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|
TN3404 |
Altholactone |
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
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|
TN3541 |
Broussonin E |
Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
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|
TN3711 |
Corylifol C |
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
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|
TN3719 |
Cristacarpin |
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
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|
TN3806 |
Dehydroglyasperin C |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
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|
TMA0291 |
Dehydroglyasperin D |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
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|
TN3839 |
Desoxo-narchinol A |
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
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|
TN3931 |
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid |
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
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|
TMA1743 |
Ergosterol peroxide |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
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|
TN4162 |
Goshonoside F5 |
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
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|
TN4317 |
Isopedicin |
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
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|
TN3003 |
4-(3,4-Dimethoxyphenyl)-3-buten-1-ol |
(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypop...
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|
TN4394 |
Kobophenol A |
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
|
|
TMA1004 |
Lucidenic acid F |
Lucidenic acid F as a modulator of JNK and p38, it shows potent inhibitory effects on EBV-EA induction.
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|
TN4490 |
Manassantin B |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
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|
TN4635 |
Neoechinulin A |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
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|
TN4648 |
Nepetoidin B |
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
|
|
TN4774 |
Physalin A |
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
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|
TN4938 |
Samidin |
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
|
|
TMA1570 |
Sappanone A |
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
|
|
TN4986 |
Selinidin |
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
|
|
TN5011 |
Shizukaol B |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
|
|
TN5050 |
Sprengerinin C |
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
|
|
TN5153 |
Torilin |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
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|
TN5174 |
Trichosanatine |
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatin...
|
|
TN3042 |
4-Hydroxycinnamamide |
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
|
|
TN2895 |
3,5-Dicaffeoyl-epi-quinic acid |
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
|
|
TN1968 |
N-Feruloyloctopamine |
N-Feruloyloctopamine is a natural product.
|
|
T12850 |
Dilmapimod |
Dilmapimod is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.
|
|
TN2039 |
Panaxydol |
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MA...
|
|
TN2075 |
Pimaric acid |
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced huma...
|
|
TN2166 |
Rupestonic acid |
Rupestonic acid derivatives have an anti-influenza virus activity, they inhibit IAV by up-regulating HO-1-mediated IFN response.
|
|
T4S0398 |
Rosin |
Rosin is a natural product,may have therapeutic potential for the treatment of inflammation
|
|
T12347 |
P38-α MAPK-IN-1 |
p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.
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|
T12348 |
P38α inhibitor 1 |
p38α inhibitor 1 is an inhibitor of p38α .
|
|
T10990 |
Dehydrocorydaline chloride |
Dehydrocorydaline chloride is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.
|
|
T10298L |
AMG-548 |
AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and ...
|
|
T14381 |
AZD7624 |
AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
|
|
T10277 |
AL 8697 |
AL 8697 is a specific and orally active p38α MAPK inhibitor (IC50: 6 nM), 14-fold less potent in p38β MAPK (IC50: 82 nM). It exhibits anti-inflammatory activit...
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|
T10298L2 |
AMG-548 dihydrochloride (864249-60-5 free base) |
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selecti...
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|
T10298 |
AMG-548 hydrochloride (864249-60-5 free base) |
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective...
|
|
T12871 |
Talmapimod |
Talmapimod is a selective, orally active and ATP-competitive inhibitor of p38α(IC50 : 9 nM) .
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|
TN2641 |
15-Methoxypinusolidic acid |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
|
|
T12997 |
SR-318 |
SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and...
|
|
T11327 |
FR 167653 |
FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo. FR 167653 , an orally active and ...
|
|
T15603 |
ITX5061 |
ITX5061 is a type II inhibitor of p38 MAPK. It also an antagonist of scavenger receptor B1.
|
|
T16159 |
Muramyl dipeptide |
Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipe...
|
|
T16424 |
P38 MAPK-IN-1 |
p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 6...
|
|
T16477 |
PF-03715455 |
PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-0371...
|
|
T16812 |
RWJ-67657 |
RWJ-67657 is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ an...
|
|
T12871L |
Talmapimod hydrochloride |
Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-f...
|
|
T2S1040 |
Jolkinolide B |
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
|
|
T3229 |
Cytochalasin D |
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertiliz...
|
|
T3S0006 |
Methyl ferulate |
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first ...
|
|
T3S0209 |
Vincristine |
Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristin...
|
|
TL0014 |
Pinusolide |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
|
|
T2293 |
SGX523 |
SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.
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