c-Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

产品编号	产品名称
T9093	NY2267	NY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM.
T12133	MYCi975	MYCi975 is an orally active inhibitor of MYC.
T3048	10058-F4	10058-F4 is a cell-permeable thiazolidinone that specifically inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression; i...
T3686	10074-G5	10074-G5 is an inhibitor of c-Myc-Max dimerization.
T4252	ML327	ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
T4367	Mycro-3	Mycro 3 is potent and selective for c-Myc in whole cell assays.
TN1354	Aaptamine	Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
TN2177	Sanggenol L	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopt...
T12132	MYCi361	MYCi361 is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).
T10352	APTO-253	APTO-253 inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates ...
T9061	EN4 MYC inhibitor	EN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional...
T10702	CBP/EP300-IN-2	CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
T15665	KJ Pyr 9	KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).
T11783	KSI-3716	KSI-3716 is an inhibitor of c-Myc.
T16839	sAJM589	sAJM589 is a Myc inhibitor(IC50: 1.8 μM).
TN3708	Coronarin D	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentratio...
TN4581	Moracin D	Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization ...
TN4582	Moracin T	Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, in...
T9033	MDK6620	MDK6620 is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and red...
T0617	Nicotinamide-N-oxide	Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enz...