首页AutophagyWnt/beta-catenin
Wnt/beta-catenin
T0738 Urea Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for about one-half of the
T10904 CWP232228 CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formatio
T11190 EMT inhibitor-1 EMT inhibitor -1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
T11571 HLY78 HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction.
T11793 KY-05009 KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK
T12537 β-catenin/CBP-IN-1 β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
T13078 Tankyrase-IN-2 Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
T14907 CCT251545 CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).
T15137 DK419 DK419 is an orally active inhibitor of Wnt/β-catenin signaling (IC50: 0.19 μM). DK419 decreases protein levels of Axin2, β-catenin, c-Myc, Cyclin D1, and Survivin. It also induc
T15633 JW74 JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).
T15639 K-756 K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 (IC50s: 31 and 36 nM, respectively).
T17142 Toxoflavin Toxoflavin is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.
T17256 Wnt pathway activator 1 Wnt pathway activator 1 is a potent Wnt activator (IC50s: 28-29 nM).
T17260 WWL70 WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
T1807 JW55 JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T1878 XAV939 XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
T1971 WAY262611 WAY-262611 is a wingless β-Catenin agonist.
T2003 Isx 9 ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.
T2052 KY02111 KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
T2237 ICG001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the rela
T22775 exo-IWR-1 exo-IWR-1 is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1 (HY-12238). IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
T2413 FH535 FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T2651 IWR-1-endo IWR-1, a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
T2702 IWP2 IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
T2818 Methyl Vanillate Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. Methy
T3062 WIKI4 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T3144 Wnt agonist 1 Wnt agonist 1 (BML-284) is a potent, selective and , cell-permeable Wnt signaling activator.
T3168 MN64 MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
T3261 NVP-TNKS656 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T3635 IQ1 Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates
T3635 IQ1 Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates
T3S0153 Xanthatin 1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin ca
T4011 NCB0846 NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
T4043 ETC159 ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
T4245 IWP 4 IWP-4 is a potent Wnt inhibitor.
T4302 iCRT3 iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
T4468 WAY 316606 WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
T4476 AS1517499 AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
T4486 iCRT 14 iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
T4S1943 Kirenol 1. Kirenol has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor
T5636 Adavivint (SM04690) Adavivint (SM04690) is a Wnt pathway inhibitor.
T5642 BC2059 BC2059 is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
T5729 L-quebrachitol L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.
T5S0754 Isoquercitrin 1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeutic agent against n
T6768 AZ6102 AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
T6842 G007-LK G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T6868 KYA1797K KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
T6989 SKL2001 SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
T7204 PNU 74654 PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway.
T7333 Pyrvinium pamoate Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pa
T7399 LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
T7830 Windorphen Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.
T8005 Cardiogenol C hydrochloride Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
T8400 Pamidronic acid Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
T8710 MSAB MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.
T8820 BML-284 HCL BML-284 HCL is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.
TL0007 Bisdemethoxycurcumin Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to sti
TL0008 Gigantol Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast c
TMA1743 Ergosterol peroxide Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inh
TN1103 Diphyllin Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
TN1694 Gliotoxin Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidati
TN2995 4,10-Aromadendranediol 4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatment of brain diseas
TN3319 9-Hydroxycanthin-6-one 9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably
TN3468 Atractylochromene Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.
TN3525 Boehmenan (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive mann
TN4046 Excisanin A ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastat
TN4583 Moringin Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune
TP1263 Fz7-21 Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells s
TQ0215 Salinomycin sodium salt Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
  • 关注公众号
    - 超值特惠
    - 客户福利
    - 业界动态
    - 实用攻略
陶素的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)。