Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine).Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part by the SPATS1 gene. The noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell. The noncanonical Wnt/calcium pathway regulates calcium inside the cell.
Inhibitors Catalog Download
产品编号 产品名称
T1878 XAV-939HOT XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
T4468 WAY 316606 WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
T4011 NCB-0846 NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
T4245 IWP-4 IWP-4 is a potent Wnt inhibitor.
T4302 ICRT3 iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
TL0007 Bisdemethoxycurcumin Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydrox...
T3S0153 Xanthatin 1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSC...
TL0008 Gigantol Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-...
T4S1943 Kirenol 1. Kirenol has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol ...
T9988 WAY-328173 WAY-328173 is a Wnt/beta-catenin agonist.
T3168 MN-64 MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
T5S0754 Isoquercetin 1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeu...
T4486 ICRT 14 iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
T5636 Adavivint Adavivint (SM04690) is a Wnt pathway inhibitor.
T5642 Tegatrabetan BC2059 is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
T5729 L-quebrachitol L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin...
T7204 PNU-74654 PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt s...
T7333 Pyrvinium pamoate Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition o...
T4043 ETC-159 ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
T3144 BML-284 Wnt agonist 1 (BML-284) is a potent, selective and , cell-permeable Wnt signaling activator.
T6989 SKL2001 SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
T3635 IQ 1 Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous different...
T2052 KY02111 KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
T1971 WAY-262611 WAY-262611 is a wingless β-Catenin agonist.
T2651 IWR-1 IWR-1, a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
T6842 G007-LK G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T3261 NVP-TNKS656 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T6768 AZ6102 AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 c...
T6868 KYA1797K KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
T3635 IQ 1 Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous different...
TQ0215 Salinomycin sodium salt Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
T2818 Methyl Vanillate Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariec...
T0738 Urea Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
T1807 JW 55 JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T2702 IWP-2 IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
T2003 ISX-9 ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.
T3062 WIKI4 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T2237 ICG001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, ...
T7399 LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
T7830 Windorphen Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.
T35610 2,5-dimethyl Celecoxib 2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis ...
TN4583 Moringin Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
TN2995 4,10-Aromadendranediol 4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN3319 9-Hydroxycanthin-6-one 9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
TN3468 Atractylochromene Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human col...
TN3525 Boehmenan (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in...
TMA1743 Ergosterol peroxide Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN4046 Excisanin A ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T22775 Exo-IWR-1 exo-IWR-1 is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling p...
T17256 Wnt pathway activator 1 Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. Wnt pathway activator 1 is a potent Wnt activator for the treatment of androgenetic a...
T22884 JW 67 JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including...
T8710 MSAB MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin ta...
T8820 BML-284 hydrochloride BML-284 HCL is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.
T9151 Teplinovivint Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. It has anti-inflammatory activity and has the potential for tendinopathy research.
TN7036 N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide N-3-methoxylBenzyllinolenicamide induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-ca...
T9557 TNIK-IN-2 TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
T9696 β-catenin-IN-2 β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
T17260 WWL70 WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
T17142 Toxoflavin Toxoflavin is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.
T8005 Cardiogenol C hydrochloride Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
T13078 Tankyrase-IN-2 Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
TP1263 Fz7-21 Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signalin...
T8400 Pamidronic acid Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
TN1694 Gliotoxin Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
T12537 β-catenin/CBP-IN-1 β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
T10904 CWP232228 CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 in...
T14907 CCT251545 CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).
T15137 DK419 DK419 is an orally active inhibitor of Wnt/β-catenin signaling (IC50: 0.19 μM). DK419 decreases protein levels of Axin2, β-catenin, c-Myc, Cyclin D1, and Surv...
T11190 EMT inhibitor-1 EMT inhibitor -1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
T11793 KY-05009 KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein ...
T11284 FIDAS-3 FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and is a...
T10641 C-82 C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
T19355 Heparan Sulfate Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
T11571 HLY78 HLY78 targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.
T15633 JW74 JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).
T15639 K-756 K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).
T15677 KY1220 KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.
T2413 FH535 FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
XAV-939 HOT
T1878CAS 284028-89-3
XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
WAY 316606
T4468CAS 915759-45-4
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
NCB-0846
T4011CAS 1792999-26-8
NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
IWP-4
T4245CAS 686772-17-8
IWP-4 is a potent Wnt inhibitor.
iCRT3
T4302CAS 901751-47-1
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
Bisdemethoxycurcumin
TL0007CAS 24939-16-0
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydrox...
Xanthatin
T3S0153CAS 26791-73-1
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSC...
Gigantol
TL0008CAS 67884-30-4
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-...
Kirenol
T4S1943CAS 52659-56-0
1. Kirenol has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol ...
WAY-328173
T9988CAS 912790-59-1
WAY-328173 is a Wnt/beta-catenin agonist.
MN-64
T3168CAS 92831-11-3
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
Isoquercetin
T5S0754CAS 482-35-9
1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeu...
iCRT 14
T4486CAS 677331-12-3
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
Adavivint
T5636CAS 1467093-03-3
Adavivint (SM04690) is a Wnt pathway inhibitor.
Tegatrabetan
T5642CAS 1227637-23-1
BC2059 is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
L-quebrachitol
T5729CAS 642-38-6
L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin...
PNU-74654
T7204CAS 113906-27-7
PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt s...
Pyrvinium pamoate
T7333CAS 3546-41-6
Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition o...
ETC-159
T4043CAS 1638250-96-0
ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
BML-284
T3144CAS 853220-52-7
Wnt agonist 1 (BML-284) is a potent, selective and , cell-permeable Wnt signaling activator.
SKL2001
T6989CAS 909089-13-0
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
IQ 1
T3635CAS 331001-62-8
Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous different...
KY02111
T2052CAS 1118807-13-8
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
WAY-262611
T1971CAS 1123231-07-1
WAY-262611 is a wingless β-Catenin agonist.
IWR-1
T2651CAS 1127442-82-3
IWR-1, a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
G007-LK
T6842CAS 1380672-07-0
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
NVP-TNKS656
T3261CAS 1419949-20-4
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
AZ6102
T6768CAS 1645286-75-4
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 c...
KYA1797K
T6868CAS 1956356-56-1
KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
IQ 1
T3635CAS 331001-62-8
Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous different...
Salinomycin sodium salt
TQ0215CAS 55721-31-8
Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
Methyl Vanillate
T2818CAS 3943-74-6
Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariec...
Urea
T0738CAS 57-13-6
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
JW 55
T1807CAS 664993-53-7
JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
IWP-2
T2702CAS 686770-61-6
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
ISX-9
T2003CAS 832115-62-5
ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.
WIKI4
T3062CAS 838818-26-1
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
ICG001
T2237CAS 847591-62-2
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, ...
LF3
T7399CAS 664969-54-4
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
Windorphen
T7830CAS 19881-70-0
Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.
2,5-dimethyl Celecoxib
T35610CAS 457639-26-8
2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis ...
Moringin
TN4583CAS 73255-40-0
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
2-Methoxystypandrone
TN2775CAS 85122-21-0
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
4,10-Aromadendranediol
TN2995CAS 70051-38-6
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
9-Hydroxycanthin-6-one
TN3319CAS 138544-91-9
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
Atractylochromene
TN3468CAS 203443-33-8
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human col...
Boehmenan
TN3525CAS 57296-22-7
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in...
Ergosterol peroxide
TMA1743CAS 2061-64-5
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
Excisanin A
TN4046CAS 78536-37-5
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
exo-IWR-1
T22775CAS 1127442-87-8
exo-IWR-1 is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling p...
Wnt pathway activator 1
T17256CAS 1360540-81-3
Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. Wnt pathway activator 1 is a potent Wnt activator for the treatment of androgenetic a...
JW 67
T22884CAS 442644-28-2
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including...
MSAB
T8710CAS 173436-66-3
MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin ta...
BML-284 hydrochloride
T8820CAS 2095432-75-8
BML-284 HCL is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.
Teplinovivint
T9151CAS 1428064-91-8
Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. It has anti-inflammatory activity and has the potential for tendinopathy research.
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
TN7036CAS 883715-23-9
N-3-methoxylBenzyllinolenicamide induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-ca...
TNIK-IN-2
T9557CAS 2754265-76-2
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
β-catenin-IN-2
T9696CAS 1458664-10-2
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
WWL70
T17260CAS 947669-91-2
WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
Toxoflavin
T17142CAS 84-82-2
Toxoflavin is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.
Cardiogenol C hydrochloride
T8005CAS 1049741-55-0
Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
Tankyrase-IN-2
T13078CAS 1588870-36-3
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
Fz7-21
TP1263CAS 2247635-23-8
Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signalin...
Pamidronic acid
T8400CAS 40391-99-9
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
Gliotoxin
TN1694CAS 67-99-2
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
β-catenin/CBP-IN-1
T12537CAS 1198780-38-9
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
CWP232228
T10904CAS 1144044-02-9
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 in...
CCT251545
T14907CAS 1661839-45-7
CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).
DK419
T15137CAS 2102672-22-8
DK419 is an orally active inhibitor of Wnt/β-catenin signaling (IC50: 0.19 μM). DK419 decreases protein levels of Axin2, β-catenin, c-Myc, Cyclin D1, and Surv...
EMT inhibitor-1
T11190CAS 1638526-21-2
EMT inhibitor -1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
KY-05009
T11793CAS 1228280-29-2
KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein ...
FIDAS-3
T11284CAS 1266684-01-8
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and is a...
C-82
T10641CAS 1422253-37-9
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
Heparan Sulfate
T19355CAS 9050-30-0
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
HLY78
T11571CAS 854847-61-3
HLY78 targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.
JW74
T15633CAS 863405-60-1
JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).
K-756
T15639CAS 130017-40-2
K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).
KY1220
T15677CAS 292168-79-7
KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.
FH535
T2413CAS 108409-83-2
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
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