| T0314 | Hexylresorcinol | Hexylresorcinol is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections. |
| T0473 | Arbutin | Arbutin(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the formation of melan |
| T0759 | Monobenzone | Monobenzone is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by means of Depigmenting A |
| T1188 | Mizoribine | Mizoribine belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. |
| T1210 | Sodium etidronate | Etidronate Disodium is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, etidronate disodium di |
| T1738 | Taxifolin | Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on. |
| T3403 | Glabridin | Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may pos |
| T3737 | Hydroumbellic acid | Hydroumbellic acid is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 3-(2, 4-dihydroxyphenyl)prop-2-enoic acid. It is generated by abkar |
| T3827 | Rhein-8-glucoside calcium salt | Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro. |
| T3923 | Calycosin | Calycosin acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycos |
| T4185 | lavendustin C | Lavendustin C is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase. |
| T6463 | Deoxyarbutin | DeoxyArbutin(IC50=50 nM) inhibits tyrosinase activity reversibly. |
| T4182 | lavendustin B | Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p |
| T4291 | (+)-Isocorydine hydrochloride | (+)-Isocorydine is a eukaryote protein kinases Inhibitor. |
| T2P2923 | Stearic acid | 1. Stearic Acid can reduce metastatic tumor burden. 2. Stearic Acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes. 3. Stearic Acid and |
| T3S1068 | Oxyresveratrol | 1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresvera |
| T3S1612 | kuwanon G | 1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes m |
| TCS2170 | 2-5-dihydroxyacetophenone | 1. 2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 |
| T7052 | Gnetol | Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin bio |
| T5552 | Methyl cinnamate | Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects. |
| T5755 | Aloesin | Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the convers |
| T7125 | 4-Butylresorcinol | 4-Butylresorcinol is a potent inhibitor of tyrosinase(IC50 : 11.27 μM), and is used in cosmetics as a depigmenting agent. |
| T5985 | Glycolic acid | Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products |
| T7438 | 3,5-Dimethoxyphenol | 3,5-Dimethoxyphenol as a marker of Taxus poisoning, being present in all species of Taxus. It has potent tyrosinase-inhibiting activity. |
| T7714 | Temocapil | Temocapril is an inhibitor of tyrosine kinase. |
| T4183 | lavendustin A | lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. |
| T6S1597 | Mulberroside A | 1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberros |
| T3382 | Wilforlide A | Wilforlide A is a natural product, separated from the ethanolic extract of tripterygium wilfordii. High-dose wilforlide A has obvious anti-inflammatory effect, but has no significa |
| T0666 | 4-Chlorosalicylic acid | 4-Chlorosalicylic acid is antimicrobial compositions comprising a metal salt and a benzoic acid analog. |
| T8087 | Tropolone | Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion |
| TN1314 | 6-Hydroxykaempferol | 6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities. |
| TN1325 | 6-Prenylnaringenin | 6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin. |
| TN1690 | Glabrene | Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely the major contribu |
| TN1928 | Methyl rosmarinate | Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmarinate shows antioxid |
| TN1958 | Mulberroside F | Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in th |
| TN2026 | Oxyresveratrol 3'-O-beta-D-glucopyranoside | Oxyresveratrol-3'-O-beta-D-glucopyranoside shows tyrosinase inhibitory activity, it may be a potential candidate as skin-whitening agents without posing any serious side effects. |
| TN2078 | Pinocembrin chalcone | Pinocembrin chalcone has tyrosinase inhibitory activity.It also shows antimutagenic effect, which is mainly due to the inhibition of the first step of enzymatic activation of heter |
| TN2148 | Retusin | Retusin behaves as pre- and postemergent herbicides. Retusin is a weak inhibitor of ATP synthesis; it exhibits potent free-radical-scavenging capacities as well as efficient inhibi |
| TN2280 | Trametenolic acid | Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.Trametenolic acid and Betulin as a new ca |
| TN2288 | Uralenol | Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate(IC50 =49 |
| TN2303 | Viscumneoside III | Viscumneoside III demonstrates high tyrosinase inhibition, it can be utilized in skin whitening cosmetics. |
| TN1772 | Isoastilbin | Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of |
| TN2025 | Oxyresveratrol 2-O-beta-D-glucopyranoside | Oxyresveratrol-2-O-beta-D-glucopyranoside shows better tyrosinase inhibitory activities than kojic acid. |
| TN1705 | Glycyrrhisoflavone | Glycyrrhisoflavone is a tyrosinase inhibitor, it also shows inhibitory effects on monoamine oxidase. |
| TN1804 | Isosilybin A | Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) o |
| TN1832 | Kanzonol C | Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition o |
| TN1840 | Kurarinol | Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhib |
| T4S1658 | Benzoyloxypeoniflorin | Benzoyloxypeoniflorin is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation. |
| T10664 | Calcium 2-oxoglutarate | Calcium 2-oxoglutarate is an intermediate in the production of GTP or ATP in the Krebs cycle. It is a reversible inhibitor of tyrosinase (IC50: 15 mM). |
| T2S0799 | Noroxyhydrastinine | Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein levels of tyrosinase, T |
| TC0017 | Haplopine | Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells. |
| TN2672 | 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran | 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities. It also shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acts as |
| TN2923 | 3'-Deoxy-4-O-methylsappanol | 3'-Deoxy-4-O-methylsappanol shows moderate cytotoxicities against cultured human melanoma HMV-II cells with the IC50 value of 872.0 uM ± 2.4. |
| TMA0593 | Broussoflavonol F | Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. Broussoflavon |
| TN3540 | Broussonin C | Broussonin C and broussin are antifungal compounds. Broussonin C exerts simple reversible slow-binding inhibition against diphenolase. |
| TN3545 | Buddlenoid A | Buddlenoid A shows high inhibition of mushroom tyrosinase. |
| TN3644 | Chlorophorin | Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; i |
| TN3753 | Dalbergioidin | Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that h |
| TN3882 | Dodoviscin A | Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthin |
| TN4117 | GB 1a | GB 1a shows potential in vitro antioxidant activities. |
| TN4148 | Glyasperin C | Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of |
| TN4179 | Haginin A | Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activation, MITF, and al |
| TN4279 | Isoderrone | Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, suggests that it may b |
| TN4580 | Morachalcone A | Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A e |
| TN4642 | Neorauflavane | Neorauflavane shows tyrosinase inhibition, it can inhibit tyrosinase monophenolase activity with an IC50 of 30 nM, it also can efficiently reduce melanin content in B16 melanoma ce |
| TMA2563 | Pedalitin | Pedalitin is a mixed-type inhibitor of tyrosinase. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl rosmarinate and Pedali |
| TN5117 | Taxiphyllin | Taxiphyllin can inhibit tyrosinase activity in vitro significantly and is a potent tyrosinase inhibitor. Taxiphyllin displays mild antibacterial activity against Staphylococcus aur |
| TN5119 | Taxoquinone | Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens. It |
| TN5153 | Torilin | Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 |
| TMA0003 | Trans-caffeic acid | Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulat |
| TN1545 | D-Tyrosine | D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine inhibits biofilm formation and trigger the s |
| T2A2524 | 4-Methoxysalicylaldehyde | 2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7. 2-hydroxy-4-methoxybenzaldehyde is a potent tyrosinase inhi |
| TN2246 | Swertiajaponin | Swertiajaponin possesses antimicrobial activity. |
