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Transferase
T0379 Risedronic Acid Risedronic acid (Risedronate ), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption.
T1455 Nialamide Nialamide is an MAO inhibitor that is used as an antidepressive agent.
T2216 Entacapone Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).
T2644 FK866 Daporinad is a small molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), with potential antineoplastic and antiangiogenic activities.
T2678 LB42708 LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).
T2700 FTI 277 hydrochloride FTI 277 hydrochloride is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I.
T2765 Rosmarinic acid Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzhei
T3182 L-778123 hydrochloride The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.
T3663 Eliglustat Eliglustat is an oral inhibitor of glucosylceramide synthase which is used in the therapy of type 1 Gaucher disease.
T6271 Tipifarnib Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved i
T6365 A922500 A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
T6373 Alendronate sodium hydrate Alendronate is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.
T6708 Tolcapone Tolcapone is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
T6844 GGTI 298 GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
T4473 Ibiglustat Ibiglustat is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a k
T4681 T863 T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1
T7439 3-Methoxybenzamide 3-Methoxybenzamide is a competitive inhibitor of poly(ADP-ribose) synthetase.
TQ0155 Miglustat hydrochloride Miglustat hydrochloride is a glucosylceramide synthase inhibitor.
T2209 Serotonin hydrochloride Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).
T12425 PF-06424439 methanesulfonate PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).
T12426 PF-06424439 PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).
T10119 3-O-Methyltolcapone 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of Parkinson
T10118 3-O-Methyltolcapone D7 3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. T
T14375 AZD3988 AZD3988 is an inhibitor of diacylglycerol acyl transferase-1 (DGAT-1). For human, rat, mouse, the IC50s values are 6, 5, 11 nM , respectively.
T11396 GGTI-2418 GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tum
T11491 GSK2973980A GSK2973980A is a selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor (IC50: 3 nM).
T11599 Ibiglustat L-Malic acid Ibiglustat L-Malic acid (Venglustat L-Malic acid) is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with the ability to cross the blood-brain barrier. It can
T13181 Tolcapone D7 Tolcapone D7 is a deuterium-labeled Tolcapone. Tolcapone is a selective and orally active inhibitor of COMT.
T16398 Opicapone Opicapone reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research of Parkinson's dis
TN3257 7beta-Methoxyrosmanol 7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.
T8489 Minodronic acid monohydrate Minodronic acid monohydrate is an farnesyl diphosphate synthase inhibitor that acts as a bone resorption inhibitor.
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