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Topoisomerase
T0125 Epirubicin hydrochloride Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
T0132 Etoposide Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50: 60.3 μM).
T0158 Mitoxantrone hydrochloride Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
T0250 Ciprofloxacin hydrochloride Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.
T0274 Cinoxacin Cinoxacin, an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid.
T0331 Moxifloxacin hydrochloride Moxifloxacin is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria as well as atypical pathogens. Moxifloxacin has been linked to mild ALT el
T0425 Pefloxacin Mesylate Pefloxacin mesylate is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
T0425L Pefloxacin Mesylate Dihydrate Pefloxacin mesylate dehydrate, an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
T0486 Irinotecan hydrochloride trihydrate Irinotecan HCl-trihydrate keeps DNA from unwinding by inhibiting topoisomerase 1.
T0486L Irinotecan Hydrochloride Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10
T0717 Enoxacin Sesquihydrate Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T0717L Enoxacin Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T0902 Ofloxacin Ofloxacin is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA
T0909 Nalidixic acid Nalidixic acid is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
T0909L Nalidixic acid sodium salt Nalidixic acid sodium salt is an antimicrobial agent with a limited bacteriocidal spectrum.
T0974 Novobiocin Sodium Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemica
T1020 Doxorubicin hydrochloride Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
T1060 Flumequine Flumequine is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and
T1095 Sparfloxacin Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
T11090L Aldoxorubicin Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomer
T1121 Podophyllotoxin Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used a
T1123 (S)-(+)-Camptothecin (S)-(+)-Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I), isolated from Camptotheca acuminata.
T11249L Dxd Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 μM). It is used as a conjugated drug of HER2-targeting ADC.
T1166 Ellipticine Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, a
T1174 Topotecan hydrochloride Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer.
T1206 Amsacrine Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topo
T1293 Gatifloxacin Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase I
T1294 Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
T1306 Norfloxacin Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
T13231 Trovafloxacin Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
T1444 Lomefloxacin Lomefloxacin is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
T1451 Levofloxacin Hemihydrate Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through
T1456 Doxorubicin Doxorubicin is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
T14703 Karenitecin Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
T1492 Gemifloxacin mesylate Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Mesylate is the mesyl
T14945 CH-0793076 CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance pro
T14953 Chloroquinoxaline sulfonamide Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T15054 Daun02 Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T15200 Edotecarin Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
T1521 Hydroxy Camptothecine Hydroxy Camptothecine is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase
T1523 Teniposide Teniposide, a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
T15586 Intoplicine Intoplicine is an inhibitor of DNA topoisomerase I and II.
T1620 Pazufloxacin Mesylate Pazufloxacin (INN) is a fluoroquinolone antibiotic.
T1625 Lomefloxacin hydrochloride Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a d
T16286 Neu2000 Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
T1640 Ciprofloxacin Ciprofloxacin, a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.
T16726 Rebeccamycin Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a n
T1703 SN38 SN-38 is an active metabolite of CPT-11.
T2160 Suramin Sodium Salt Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, includ
T22456 Voreloxin hydrochloride Voreloxin is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
T2394 Pixantrone dimaleate Pixantrone dimaleate (BBR 2778 dimaleate) is an experimental antineoplastic drug.
T2764 10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T2830 Betulinic acid Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial,
T2937 4'-Demethylepipodophyllotoxin 4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
T3117 Marbofloxacin Marbofloxacin is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.
T3181 SW044248 SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
T3186 NU2058 NU2058 is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
T3339 Sophoridine Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their c
T3481 Bimolane Bimolane is a topoisomerase II inhibitor.
T3S1957 9-Aminocamptothecin 9-Aminocamptothecin is an inhibitor of topoisomerase I with potent anticancer activity.
T4047 Bisantrene Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, D
T4614 Ellipticine hydrochloride Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
T4952 10-Hydroxycampothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T5394 Prulifloxacin Prulifloxacin is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II and IV.
T5784 Topotecan Topotecan is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
T5820 Amsacrine hydrochloride Amsacrine hydrochloride  is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.
T5853 Rubitecan Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manne
T5S1952 9-Methoxycamptothecin 9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
T6010 Idarubicin HCl Idarubicin HCl, a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).
T6228 Irinotecan Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase
T6336 Amonafide Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
T6467 Dexrazoxane HCl Dexrazoxane HCl is a cardio-protective drug.
T6567 Levofloxacin Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
T6588 Mitoxantrone Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agen
T6628 Pirarubicin Pirarubicin is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as an antineoplastic a
T6724 Voreloxin Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
T7048 1,4-Naphthoquinone 1, 4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].
T7187 Genz-644282 Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
T7309 TAS-103 (dihydrochloride) TAS-103 (dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.
T7551 Belotecan hydrochloride Belotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
T8747 Levofloxacin hydrochloride Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through
TN1169 1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside 1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
TN1375 alpha-Lapachone alpha-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.
TN1734 Heveaflavone Heveaflavone has anti-proliferation effects, it shows moderate Topoisomerase I inhibitory activity. It also possesses a good antioxidant activity via its DPPH free radical scavengi
TN1886 Lucidin 3-O-primeveroside Lucidin-3-O- primeveroside, a food pigment, shows effective antifeedant against the carpet beetle. It is reported to be carcinogenic in the kidney and liver of rats. Lucidin-3-O-α
TN1889 Lupalbigenin Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN1917 Mauritianin Mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors. Mauritianin has statistically significant cytoprotective activity similar to that of silymarin, tested at 60 u
TN2105 Proscillaridin A Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
TN2105 Proscillaridin A Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
TN2464 Eleutherin Eleutherin is a natural product from Eleutherine americana
TN2953 3-Hydroxysarpagine Standard reference
TN4107 Ganoderic acid X Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN4172 Guajadial B Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most eff
TN4173 Guajadial C Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
TN4283 Isodiospyrin Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the minimum inhibitory con
TN4422 Lauterine Lauterine is a DNA topoisomerase inhibitor.
TN4660 Niranthin Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interac
TN4923 Rubicordifolin Rubicordifolin exhibits potent cytotoxic and antitumor activities.
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably a
TN5190 Tryprostatin A Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at
TQ0049 MC-DOXHZN hydrochloride MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
TQ0063 Zoliflodacin Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negati
TQ0088 Exatecan Mesylate Exatecan Mesylate is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).
TQ0134 Podocarpusflavone A Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
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