首页AutophagyTRP/TRPV Channel
TRP/TRPV Channel
T0457 Probenecid Probenecid is a benzoic acid derivative with antihyperuricemic property.
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace a
T0882 D-Camphor (+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
T1062 Capsaicin Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open below 37 °C This i
T1321 Nonivamide Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid.
T1814 ICILIN Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
T2007 RQ00203078 RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
T2170 SKF-96365 hydrochloride SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cytoprotective autopha
T2298 ML204 ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T2711 TCS 5861528 TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
T2845 Imperatorin Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2994 Cardamonin Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hT
T3727 Methyl syringate Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specifi
T4028 ML329 ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
T6379 AMG517 AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.
T6530 HC030031 HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
T6617 Optovin Optovin is a TRPA1 activator, which is reversibly photoactivated.
T6660 SB705498 SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
T6848 GSK1016790A GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.
T6977 SB366791 SB-366791 is a new and selective cinnamide TRPV1 antagonist.
T4385 PF4840154 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and
T3865 beta-Eudesmol β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and
T4699 Hexamethylene amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for variou
T4680 HC067047 HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
T5479 AMG-333 AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
T5640 GSK2193874 GSK2193874 was identified as a selective, orally active TRPV4 blocker.
T5786 TETRAHYDROPIPERINE TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
T5698 TRPM8 antagonist 2 TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
T5962 N-Ethyl-p-menthane-3-carboxamide N-Ethyl-p-menthane-3-carboxamide is an agonist of TRPM8( EC50 : 3.7 μM).
T7205 A 967079 A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.
T7177 Capsazepine Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) whic
T7102 BCTC BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
T7189 AMG9810 AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).
T7416 WS-12 WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)
T7572 RN-1734 RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4,  mTRPV4 and rTRPV4,respectively)
T7526 JNJ-17203212 JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
TQ0001 1,4-Cineole 1,4-Cineole is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
T7430 AM-0902 AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
TQ0157 EIPA EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
T8307 Hydroxy-​α-​sanshool Hydroxy-​α-​sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 µM).
T8410 ASP7663 ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
TN1583 Dihydromorin trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal melanocytes, indicat
T14067 A-1165442 A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
T8425 Linoleoyl Ethanolamide Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent ma
T13546 AM12 AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
T10300 AMG2850 AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
T11394 GFB-8438 GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
T11172 EIPA hydrochloride EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.
T13212 TRPA1 Antagonist 1 TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
T15434 GSK2798745 GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in research for the tr
T15439 GSK3395879 GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
T15628 JT010 JT010 is an effective agonist of TRPA1 (EC50: 0.65 nM).
T15634 JYL 1421 JYL 1421 is an antagonist of TRPV1 receptor (IC50: 8 nM).
T8528 AC1903 AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
T16483 PF-05105679 PF-05105679 has the potential for cold-related pain. PF-05105679 is an orally active and selective TRPM8 antagonist (IC50: 103 nM).
T16532 Pico145 Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits (−)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect
T16763 RN-1747 RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rTRPV4 respectively).
T15758 Linopirdine Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is a cognitive enhan
T17006 TC-I 2014 TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50
T8562 A 425619 A 425619 is a potent TRPV1 antagonist
T8565 N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.
T8607 M-084 hydrochloride M-084 hydrochloride is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.
TN4469 (+)-Lyoniresinol Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling,
T16686 Pyr10 Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule
T1109 Zucapsaicin Zucapsaicin is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.Zucapsaicin is a synthetic cis isomer of natural capsaicin that has shown therapeut
T10537 BI-749327 BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
T2952 Camphor Camphor is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
T2807 Caffeic Acid Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities.
T16688 Pyr6 Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays hi
T13214L TRPV4 agonist-1 free base TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
T8449 TC-I2000 TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
T8442 M8-B Hydrochloride M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.
T8440 LASSBio-1135 LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
T4693 2-APB 2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).
T0399 Methyl salicylate Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular
T0399 Methyl salicylate Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular
TN1377 alpha-Spinasterol α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inh
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