| T0008 | Phenytoin sodium | Phenytoin sodium is an inactive stabilizer for voltage-gated sodium channel . |
| T0012 | Cinchonine | Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its paren |
| T0018 | Procainamide hydrochloride | Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydr |
| T0024 | Primidone | Primidone is an anticonvulsant of the pyrimidinedione class. |
| T0029 | Procaine | Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and sp |
| T0030 | Bupivacaine hydrochloride | Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivacaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a de |
| T0044 | Oxethazaine | Oxethazaine, a topical anesthetic, is used to prevent acid-induced esophageal pain. |
| T0167 | Vinpocetine | Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). |
| T0175L | Amiloride hydrochloride dihydrate | Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the |
| T0207 | Ranolazine dihydrochloride | Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect bloo |
| T0222 | Proparacaine hydrochloride | Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuro |
| T0249 | Acecainide | N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug. |
| T0266 | Quinidine hydrochloride | Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. |
| T0267 | Zonisamide | Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is |
| T0275 | Meticrane | Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity. |
| T0349 | Riluzole | Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS. |
| T0364 | Dibucaine | Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia. |
| T0364L | Dibucaine hydrochloride | Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia. |
| T0378 | Oxybuprocaine hydrochloride | Oxybuprocaine hydrochloride, a local anesthetic, is used especially in otolaryngology and ophthalmology. |
| T0386 | Ropivacaine hydrochloride | Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. |
| T0386L | Ropivacaine | Ropivacaine is a local anaesthetic drug belonging to the amino amide group. |
| T0440 | Oxcarbazepine | Oxcarbazepine is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
| T0460 | Pramoxine hydrochloride | Pramocaine hydrochloride, a topical anesthetic, is served as an antipruritic. |
| T0470 | Nefopam hydrochloride | Nefopam Hydrochloride is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity. |
| T0511 | Tolperisone hydrochloride | Tolperisone hydrochloride, a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological disease |
| T0792 | (-)-Sparteine sulfate pentahydrate | Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium. |
| T0796 | Propitocaine hydrochloride | Prilocaine hydrochloride is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of |
| T0802 | Procaine hydrochloride | Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibi |
| T0843 | Ademine | Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. |
| T0866 | Propafenone | Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has wea |
| T0916 | Butyl 4-aminobenzoate | Butamben is a long-duration local anesthetic used for the treatment of chronic pain. |
| T0924 | Benzocaine | Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. |
| T0939 | Phenytoin | Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons l |
| T0943 | Carbamazepine | Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant ac |
| T0946 | Mepivacaine hydrochloride | Mepivacaine Hydrochloride is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. |
| T1046 | Mexiletine hydrochloride | Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts i |
| T1073 | Dronedarone hydrochloride | Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation. |
| T10757L | Cenobamate | Cenobamate, a sodium channel blocker, enhances GABAergic transmission. It has the potential to be a versatile CNS drug. |
| T1144 | Lidocaine hydrochloride | Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROC |
| T1144L | Lidocaine Hydrochloride hydrate | Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property. |
| T1198 | Tetracaine hydrochloride | Tetracaine hydrochloride (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmolog |
| T12608 | QX-314 chloride | QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel. |
| T12951 | Sodium Channel inhibitor 2 | Sodium Channel inhibitor 2 is a blocker of sodium channel. |
| T1300 | Propofol | Propofol is an intravenous anesthetic agent used for induction and maintenance of general anesthesia. |
| T1308 | Orphenadrine hydrochloride | Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. |
| T13177 | Tocainide hydrochloride | Tocainide hydrochloride is a blocker of the sodium channel and used for the treatment of tinnitus. |
| T1320 | Disopyramide | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant act |
| T1332 | Permethrin | Permethrin is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES. |
| T1334 | Hydroquinidine | Dihydroquinidine is an organic compound, used as an antiarrhythmic agent. |
| T13830 | Propoxycaine hydrochloride | Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels. |
| T1386 | Phenazopyridine hydrochloride | Phenazopyridine Hydrochloride is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the ox |
| T1389 | Dyclonine hydrochloride | Dyclonine, an over the counter throat lozenge, is found in Sucretswith local anesthetic effect . |
| T15260 | Evenamide | Evenamide is a sodium channel blocker. It shows efficacy in a broad spectrum of rodent models of psychosis, depression, mania, and aggressiveness. |
| T16707 | QX-314 bromide | QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel. |
| T16887 | Sipatrigine | Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel. |
| T1787 | Levobupivacaine | Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydr |
| T19644 | Benzonatate | Benzonatate is an antagonist of sodium channel protein. |
| T2024 | A803467 | A-803467 is a selective NaV1.8 channel blocker. |
| T2049 | GS967 | GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ). |
| T2131 | Articaine HCl | Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE. |
| T2139 | Butacaine | Butacaine is a local anesthetic. |
| T2173 | Veratridine | Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal. |
| T2192 | Indazole | Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound. Indazole derivatives display a broad variety of biological activities. |
| T2342 | CNV1014802 | Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. |
| T2391 | Camostat mesilate | Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function. |
| T2523 | Rufinamide | Rufinamide, a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders. |
| T2806 | Lappaconitine | Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic. |
| T2S0820 | Karanjin | Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce |
| T3029 | Sparteine sulfate | Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium. |
| T3285 | Eslicarbazepine Acetate | Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are |
| T3364 | Veratramine | Veratramine(NSC17821; NSC23880) is a potent signal transduction inhibitor for treating tumors. |
| T4490 | PF01247324 | PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM). |
| T4539 | Nicainoprol | Nicainoprol is a fast-sodium-channel blocking drug, which is a potent antiarrhythmic agent. |
| T4550 | Ajmaline | Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inh |
| T4699 | Hexamethylene amiloride | HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for variou |
| T5319 | Rimeporide | Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor. |
| T5324 | BI 01383298 | BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). |
| T5333 | Rimeporide hydrochloride | Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor. |
| T5850 | Benzamil (hydrochloride) | Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. |
| T6234 | Ambroxol hydrochloride | Ambroxol hydrochloride is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydr |
| T6541 | Ibutilide Fumarate | Ibutilide Fumarate is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current |
| T6566 | Levobupivacaine HCl | Levobupivacaine HCl is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic. |
| T6782 | Benzocaine hydrochloride | Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. |
| T6782L | Benzocaine xHCl(94-09-7(free base)) | Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV). |
| T6953 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures. |
| T6955 | Propafenone HCl | Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. |
| T7056 | Dronedarone | Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. |
| T7064 | Valproic Acid | Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms o |
| T7066 | Fosphenytoin sodium | Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker |
| T7182 | Metaflumizone | Metaflumizone is a sodium channel blocker insecticide. |
| T7190 | Actein | Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic p |
| T7219 | Flecainide (acetate) | Flecainide (acetate) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart). |
| T7336 | ICA-121431 | ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels. |
| T7349 | Ralfinamide | Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions. |
| T7547 | Ralfinamide mesylate | Ralfinamide mesylate is an orally available Na+ channel blocker. |
| T7811 | Pilsicainide HCl | Pilsicainide HCl is a pure sodium channel blocker |
| T8299 | Dimethyl lithospermate B | Dimethyl lithospermate B is a selective Na+ channel agonist. |
| T8444 | N-Me-aminopyrimidinone9 | N-Me-aminopyrimidinone9 is a sodium channel antagonist |
| T8711 | PF-05186462 | PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5. |
| TCA2511 | 11Beta-hydroxyprogesterone | The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mine |
| TN1740 | Homoeriodictyol | Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-media |
| TN2054 | Periplocymarin | Periplocymarin, a cardiac glycoside, has potential anti-cancer activity. |
| TN2239 | Strictosamide | Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain. |
| TN2306 | Wilfordine | Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect. |
| TN3042 | 4-Hydroxycinnamamide | 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. |
| TN3910 | Ecdysone | Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D and activates the ex |
| TN4276 | Isocudraniaxanthone B | Isocudraniaxanthone B may have antimalarial activity. |
| TN4697 | Odoroside H | Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase. |
| TN5060 | Stauntosaponin A | Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively. |
| TN5141 | Thevetin B | Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors. |
| TN5234 | Vindorosine | Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles. |
| TQ0011 | PF-06869206 | PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM). |
| TQ0014 | GNE-131 | GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM). |
| TQ0157 | EIPA | EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
