||Phenytoin sodium is an inactive stabilizer for voltage-gated sodium channel .
||Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its paren
||Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydr
||Primidone is an anticonvulsant of the pyrimidinedione class.
||Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and sp
||Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivacaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a de
||Oxethazaine, a topical anesthetic, is used to prevent acid-induced esophageal pain.
||Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
||Amiloride hydrochloride dihydrate
||Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the
||Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect bloo
||Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuro
||N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
||Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity.
||Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is
||Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
||Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
||Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
||Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
||Oxybuprocaine hydrochloride, a local anesthetic, is used especially in otolaryngology and ophthalmology.
||Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
||Ropivacaine is a local anaesthetic drug belonging to the amino amide group.
||Oxcarbazepine is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
||Pramocaine hydrochloride, a topical anesthetic, is served as an antipruritic.
||Nefopam Hydrochloride is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
||Tolperisone hydrochloride, a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological disease
||(-)-Sparteine sulfate pentahydrate
||Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
||Prilocaine hydrochloride is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of
||Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibi
||Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
||Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has wea
||Butamben is a long-duration local anesthetic used for the treatment of chronic pain.
||Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
||Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons l
||Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant ac
||Mepivacaine Hydrochloride is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.
||Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts i
||Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
||Cenobamate, a sodium channel blocker, enhances GABAergic transmission. It has the potential to be a versatile CNS drug.
||Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROC
||Lidocaine Hydrochloride hydrate
||Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.
||Tetracaine hydrochloride (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmolog
||QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
||Sodium Channel inhibitor 2
||Sodium Channel inhibitor 2 is a blocker of sodium channel.
||Propofol is an intravenous anesthetic agent used for induction and maintenance of general anesthesia.
||Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
||Tocainide hydrochloride is a blocker of the sodium channel and used for the treatment of tinnitus.
||A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant act
||Permethrin is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
||Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
||Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.
||Phenazopyridine Hydrochloride is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the ox
||Dyclonine, an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
||Evenamide is a sodium channel blocker. It shows efficacy in a broad spectrum of rodent models of psychosis, depression, mania, and aggressiveness.
||QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel.
||Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
||Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydr
||Benzonatate is an antagonist of sodium channel protein.
||A-803467 is a selective NaV1.8 channel blocker.
||GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
||Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
||Butacaine is a local anesthetic.
||Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
||Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound. Indazole derivatives display a broad variety of biological activities.
||Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
||Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
||Rufinamide, a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
||Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
||Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce
||Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
||Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are
||Veratramine(NSC17821; NSC23880) is a potent signal transduction inhibitor for treating tumors.
||PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
||Nicainoprol is a fast-sodium-channel blocking drug, which is a potent antiarrhythmic agent.
||Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inh
||HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for variou
||Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
||BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
||Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
||Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.
||Ambroxol hydrochloride is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydr
||Ibutilide Fumarate is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current
||Levobupivacaine HCl is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic.
||Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
||Benzocaine xHCl(94-09-7(free base))
||Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).
||Prilocaine is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
||Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
||Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
||Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms o
||Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
||Metaflumizone is a sodium channel blocker insecticide.
||Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic p
||Flecainide (acetate) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
||ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.
||Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
||Ralfinamide mesylate is an orally available Na+ channel blocker.
||Pilsicainide HCl is a pure sodium channel blocker
||Dimethyl lithospermate B
||Dimethyl lithospermate B is a selective Na+ channel agonist.
||N-Me-aminopyrimidinone9 is a sodium channel antagonist
||PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
||The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mine
||Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-media
||Periplocymarin, a cardiac glycoside, has potential anti-cancer activity.
||Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
||Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
||4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
||Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D and activates the ex
||Isocudraniaxanthone B may have antimalarial activity.
||Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
||Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
||Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 184.108.40.206) inhibitors.
||Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
||PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
||GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
||EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.