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Sodium Channel
T0008 Phenytoin sodium Phenytoin sodium is an inactive stabilizer for voltage-gated sodium channel .
T0012 Cinchonine Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its paren
T0018 Procainamide hydrochloride Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydr
T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T0029 Procaine Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and sp
T0030 Bupivacaine hydrochloride Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivacaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a de
T0044 Oxethazaine Oxethazaine, a topical anesthetic, is used to prevent acid-induced esophageal pain.
T0167 Vinpocetine Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T0175L Amiloride hydrochloride dihydrate Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the
T0207 Ranolazine dihydrochloride Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect bloo
T0222 Proparacaine hydrochloride Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuro
T0249 Acecainide N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
T0266 Quinidine hydrochloride Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity.
T0267 Zonisamide Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is
T0275 Meticrane Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
T0349 Riluzole Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
T0364 Dibucaine Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
T0364L Dibucaine hydrochloride Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
T0378 Oxybuprocaine hydrochloride Oxybuprocaine hydrochloride, a local anesthetic, is used especially in otolaryngology and ophthalmology.
T0386 Ropivacaine hydrochloride Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
T0386L Ropivacaine Ropivacaine is a local anaesthetic drug belonging to the amino amide group.
T0440 Oxcarbazepine Oxcarbazepine is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T0460 Pramoxine hydrochloride Pramocaine hydrochloride, a topical anesthetic, is served as an antipruritic.
T0470 Nefopam hydrochloride Nefopam Hydrochloride is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
T0511 Tolperisone hydrochloride Tolperisone hydrochloride, a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological disease
T0792 (-)-Sparteine sulfate pentahydrate Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T0796 Propitocaine hydrochloride Prilocaine hydrochloride is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibi
T0843 Ademine Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
T0866 Propafenone Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has wea
T0916 Butyl 4-aminobenzoate Butamben is a long-duration local anesthetic used for the treatment of chronic pain.
T0924 Benzocaine Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T0939 Phenytoin Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons l
T0943 Carbamazepine Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant ac
T0946 Mepivacaine hydrochloride Mepivacaine Hydrochloride is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.
T1046 Mexiletine hydrochloride Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts i
T1073 Dronedarone hydrochloride Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T10757L Cenobamate Cenobamate, a sodium channel blocker, enhances GABAergic transmission. It has the potential to be a versatile CNS drug.
T1144 Lidocaine hydrochloride Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROC
T1144L Lidocaine Hydrochloride hydrate Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.
T1198 Tetracaine hydrochloride Tetracaine hydrochloride (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmolog
T12608 QX-314 chloride QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
T12951 Sodium Channel inhibitor 2 Sodium Channel inhibitor 2 is a blocker of sodium channel.
T1300 Propofol Propofol is an intravenous anesthetic agent used for induction and maintenance of general anesthesia.
T1308 Orphenadrine hydrochloride Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T13177 Tocainide hydrochloride Tocainide hydrochloride is a blocker of the sodium channel and used for the treatment of tinnitus.
T1320 Disopyramide A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant act
T1332 Permethrin Permethrin is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
T1334 Hydroquinidine Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
T13830 Propoxycaine hydrochloride Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.
T1386 Phenazopyridine hydrochloride Phenazopyridine Hydrochloride is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the ox
T1389 Dyclonine hydrochloride Dyclonine, an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
T15260 Evenamide Evenamide is a sodium channel blocker. It shows efficacy in a broad spectrum of rodent models of psychosis, depression, mania, and aggressiveness.
T16707 QX-314 bromide QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel.
T16887 Sipatrigine Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
T1787 Levobupivacaine Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydr
T19644 Benzonatate Benzonatate is an antagonist of sodium channel protein.
T2024 A803467 A-803467 is a selective NaV1.8 channel blocker.
T2049 GS967 GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
T2131 Articaine HCl Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
T2139 Butacaine Butacaine is a local anesthetic.
T2173 Veratridine Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
T2192 Indazole Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound. Indazole derivatives display a broad variety of biological activities.
T2342 CNV1014802 Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
T2391 Camostat mesilate Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
T2523 Rufinamide Rufinamide, a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
T2806 Lappaconitine Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
T2S0820 Karanjin Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce
T3029 Sparteine sulfate Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T3285 Eslicarbazepine Acetate Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are
T3364 Veratramine Veratramine(NSC17821; NSC23880) is a potent signal transduction inhibitor for treating tumors.
T4490 PF01247324 PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
T4539 Nicainoprol Nicainoprol is a fast-sodium-channel blocking drug, which is a potent antiarrhythmic agent.
T4550 Ajmaline Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inh
T4699 Hexamethylene amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for variou
T5319 Rimeporide Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
T5324 BI 01383298 BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
T5333 Rimeporide hydrochloride Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
T5850 Benzamil (hydrochloride) Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.
T6234 Ambroxol hydrochloride Ambroxol hydrochloride is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydr
T6541 Ibutilide Fumarate Ibutilide Fumarate is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current
T6566 Levobupivacaine HCl Levobupivacaine HCl is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic.
T6782 Benzocaine hydrochloride Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T6782L Benzocaine xHCl(94-09-7(free base)) Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).
T6953 Prilocaine Prilocaine is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
T6955 Propafenone HCl Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
T7056 Dronedarone Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T7064 Valproic Acid Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms o
T7066 Fosphenytoin sodium Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
T7182 Metaflumizone Metaflumizone is a sodium channel blocker insecticide.
T7190 Actein Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic p
T7219 Flecainide (acetate) Flecainide (acetate) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
T7336 ICA-121431 ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.
T7349 Ralfinamide Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
T7547 Ralfinamide mesylate Ralfinamide mesylate is an orally available Na+ channel blocker.
T7811 Pilsicainide HCl Pilsicainide HCl is a pure sodium channel blocker
T8299 Dimethyl lithospermate B Dimethyl lithospermate B is a selective Na+ channel agonist.
T8444 N-Me-aminopyrimidinone9 N-Me-aminopyrimidinone9 is a sodium channel antagonist
T8711 PF-05186462 PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
TCA2511 11Beta-hydroxyprogesterone The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mine
TN1740 Homoeriodictyol Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-media
TN2054 Periplocymarin Periplocymarin, a cardiac glycoside, has potential anti-cancer activity.
TN2239 Strictosamide Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
TN2306 Wilfordine Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
TN3042 4-Hydroxycinnamamide 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN3910 Ecdysone Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D and activates the ex
TN4276 Isocudraniaxanthone B Isocudraniaxanthone B may have antimalarial activity.
TN4697 Odoroside H Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
TN5060 Stauntosaponin A Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
TN5141 Thevetin B Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors.
TN5234 Vindorosine Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
TQ0011 PF-06869206 PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
TQ0014 GNE-131 GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
TQ0157 EIPA EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
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