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S1P Receptor
T10305 Amiselimod hydrochloride Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T10385 ASP-4058 ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
T11747 KD-3010 KD-3010 is a orally, potent active, and selective PPARδ agonist.
T12436 PF-543 Citrate PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T12437 PF429242 dihydrochloride PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
T12927 SK1-IN-1 SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T15032 CYM50308 CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations u
T17183 TY-52156 TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T17237 VPC 23019 VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07,
T2026 CYM5442 CYM5442 is an S1P agonist, targeting to Sphingosine.
T2171 SEW2871 Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
T22703 CYM 5520 noncompetitive allosteric agonist of S1P2
T2539 Fingolimod hydrochloride Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T3258 Ponesimod Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating activity.
T3961 CYM 5541 CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T4031 S1p-receptor-agonist-1 An S1P receptor agonist.
T4658 MHP MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
T6085 PF543 PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T6403 Siponimod BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for
T6673 SKI II SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2.
T6750 ABC294640 ABC294640 is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
T6923 Ozanimod Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis,
T7360 GSK2018682 GSK2018682 is an agonist of sphingosine-1-phosphate receptor  (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T7939 Fingolimod Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T8461 SKI V SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and ha
T8840 PF-543 PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
TQ0138 K145 hydrochloride K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.
TQ0198 Phorbol 12-myristate 13-acetate Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
TQ0227 Etrasimod Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
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