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Retinoid Receptor
T1002 Etodolac Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Et
T1051 Tretinoin Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and in
T1093 Adapalene Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
T1288 TTNPB TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.
T1330 Acitretin Acitretin is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
T1611 Isotretinoin Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretin
T1872 Fenretinide Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
T3955 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.
T6410 Bexarotene Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
T6694 Tamibarotene Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
T6696 Tazarotene Tazarotene is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abn
T6831 Etretinate Etretinate is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell diffe
T4371 CD437 CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
T4538 palovarotene Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
T5341 WYC209 WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
T5854 AM580 AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
T5843 R-flurbiprofen R-flurbiprofen is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease.
TQ0064 Peretinoin Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
TQ0097 AGN 193109 AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T14143 AGN 194310 AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
T14689 BMS493 BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepressor interaction wit
T14911 CD2665 CD2665 is an antagonist of RAR-beta/gamma (Ki: 110 nM and 306 nM for RARγ and RARβ).
T14912 CD3254 CD3254 a selective agonist of retinoid-X-receptor (RXR).
T14946 Ch55 Ch55 is a potent inducer of the differentiation of HL60 cells (EC50: 200 nM). Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 shows a low affinity for cellular r
T15825 LY 178002 LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of LTB4 by human pol
T16425 PA452 PA452 is a retinoic X receptor (RXR) specific antagonist. PA452 suppresses the effect of Retinoic acid (RA) on Th1/Th2 development.
T11844 LG-100064 LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
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