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Reductase
T0488 Finasteride Finasteride is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.
T0725 Isoliquiritigenin Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM).
T1076 Dexamethasone Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccha
T1458 Epalrestat Epalrestat, an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progre
T1499 Dutasteride Dutasteride is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.
T2013 Ponalrestat Ponalrestat is an aldose reductase inhibitor.
T3665 Tectoridin Tectoridin possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglyce
T3915 Ginsenoside Ro GinsenosideRo exhibits a Ca2+-antagonistic antiplatelet effect.
T6S0840 Engeletin 1. Engeletin may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a reco
T6102 2'-acetylacteoside 2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows
T6S2384 Poliumoside Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibito
T5195 Alrestatin Alrestatin is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
T4918 DL-Glyceraldehyde Glyceraldehyde is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficien
T5813 BYAKANGELICIN BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuro
TN2295 Vicenin -1 Vicenin-1 possesses potent anti-inflammatory and anti-oxidant activity.
T10393 AT-007 AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease compli
T15281 Fidarestat Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabet
T17114 Tolrestat Tolrestat is a potent and orally active inhibitor of aldose reductase (IC50: 35 nM).
TN3287 8-Lavandulylkaempferol 8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows
TN3760 Danshenol A Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor
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