首页AutophagyPotassium Channel
Potassium Channel
T0075 Nicorandil Nicorandil(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating po
T0126 Diazoxide Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide g
T0127 Glimepiride Glimepiride is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
T0161 Pantoprazole Sodium Hydrate Pantoprazole is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
T0266 Quinidine hydrochloride Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity.
T0342 Carvedilol phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimeti
T0344 Miconazole Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
T0365 Thioridazine hydrochloride Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T0371 Gliquidone Gliquidone is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 a
T0386 Ropivacaine hydrochloride Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
T0447 Carvedilol Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimeti
T0451 Minoxidil Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.
T0483 Sotalol hydrochloride Sotalol Hydrochloride is the hydrochloride salt form of sotalol, an ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties.
T0690 Quinine Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy
T0700 Ursodeoxycholic acid Ursodeoxycholic acid can be used to dissolve gallstones and reduce cholesterol absorption.
T0791 Reserpine Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion o
T0816 Acetohexamide Acetohexamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying pot
T0847 Chenodeoxycholic acid Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small inte
T0866 Propafenone Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has wea
T0954 Anestan Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE
T0974 Albamycinsodium Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemica
T1050 Prazosin hydrochloride Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin
T1054 Tolbutamide Tolbutamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
T1073 Dronedarone hydrochloride Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T1088 Repaglinide Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare inst
T1138 Taurocholic acid sodium salt hydrate Taurocholic acid sodium salt hydrate is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous animals, is used as
T1146 Nifedipine Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscl
T1204 Bendroflumethiazide A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary trac
T1206 Amsacrine Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topo
T1260 Sodium cromoglycate Cromolyn sodium is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
T1266 Terfenadine Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative
T1278 Astemizole Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less antichol
T1291 Cisapride Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase
T1320 Disopyramide A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant act
T1333 Tolazamide Tolazamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
T1334 Hydroquinidine Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
T1449 Hydrochlorothiazide Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
T1453 Phenformin hydrochloride Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T1496 Amiodarone hydrochloride Amiodarone hydrochloride is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and
T1498 Indapamide Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
T1527 Gliclazide Gliclazide, an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to release insulin.
T1530 Mitiglinide calcium Mitiglinide is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic be
T1634 Glyburide Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1650 Chlorzoxazone Chlorzoxazone is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
T1674 Nateglinide Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide h
T1752 NS6180 NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.
T2546 Pimozide Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the centr
T3102 NS 1619 NS1619 have cardio-protective effects after ischemia-reperfusion injury.
T3332 Isosteviol Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol
T3528 Senicapoc Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 va
T3557 GAL-021 GAL-021 an intravenous BKCa-channel blocker.
T3581 KS176 KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or MRP1.
T3959 ICA069673 ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
T4030 ML213 ML213 is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.
T4224 ML335 ML335 is a selective activator of both TREK-1 and TREK-2.
T4316 ML365 ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
T4612 NS309 NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90
T5180 SKA-31 SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).
T5183 AUT1 AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).
T5336 Zacopride hydrochloride Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
T5444 CLP-290 CLP290 is an activator of the neuron-specific K+-Cl- cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.
T5585 AM-92016 hydrochloride AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the duration of the nerv
T6476 Dofetilide Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed r
T6504 Flupirtine maleate Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel op
T6592 ML133 HCl ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
T6631 Quinine HCl Dihydrate Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
T6978 Almitrine dimesylate Almitrine dimesylate inhibits selectively the Ca2+-dependent K+ channel and that in rat chemoreceptor cells,used in the treatment of hypoxemic chronic lung diseases.
T7056 Dronedarone Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T7195 GSK369796 Dihydrochloride GSK369796 Dihydrochloride,is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM)
T7198 E-4031 E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)
T7505 Azimilide Dihydrochloride Azimilide Dihydrochloride, a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassiu
T7512 BMS-191011 BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models
T7612 ICA 110381 ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy
T7653 JNJ 303 JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
T7775 A2764 dihydrochloride A2764 dihydrochloride is a highly selective inhibitor of TRESK.
TQ0139 VU 0240551 VU 0240551 is a neuronal K-Cl cotransporter KCC2 inhibitor (IC50: 560 nM for K+ uptake assay in KCC2-overexpressing cells).
TQ0150 Levcromakalim Levcromakalim is an activator of the ATP-sensitive K+ channel.
TQ0179 PAP-1 PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
TQ0307 Vernakalant Vernakalant (RSD-1235) is a mixed ion channel blocker.
  • 关注公众号
    - 超值特惠
    - 客户福利
    - 业界动态
    - 实用攻略
陶素的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)。