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Porcupine
T2242 Wnt-C59 Wnt-C59(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
T2618 LGK974 LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colore
T2683 IWP-L6 IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
T4438 Porcupine-IN-1 Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
T5342 IWP-O1 IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
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