||PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
||Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
||Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
||DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
||Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathway and inhibit TN
||ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft m
||DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.