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PKM
T4170 PKM2 inhibitor PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
T4223 Mitapivat Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
T6744 Methylbenactyzine Bromide Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
T6816 DASA58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
T1125 (+)-Shikonin Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathway and inhibit TN
T7214 ML265 ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft m
T8363 DL-Serine DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
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