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P2 Receptor
T0179 Ticagrelor Ticagrelor, produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The drug was approved f
T0182 (S)-Clopidogrel Clopidogrel, a P2Y12 receptor antagonist, decreases platelet aggregation.
T0182L (S)-(+)-Clopidogrel hydrogen sulfate (S)-(+)-Clopidogrel hydrogensulfate, a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation.
T0182L2 (±) Clopidogrel hydrogen sulfate Clopidogrel, an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cerebrovascular disease
T0230 Prasugrel Prasugrel is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL
T0362 Ticlopidine hydrochloride Ticlopidine hydrochloride is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
T1131 Ivermectin Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T2087 AF 353 AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T2673 A-438079 hydrochloride A-438079 hydrochloride is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9.
T3536 AZD1283 AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced
T3639 A804598 A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
T3690 A 740003 A 740003 is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammato
T4132 BPTU Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mo
T6172 MRS 2578 MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
T6526 GW791343 3HCl GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
T6952 Prasugrel Hydrochloride Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.
T3578 Pyridoxal phosphate Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, deca
T4699 Hexamethylene amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for variou
T3345 Hederasaponin B Hederasaponin B has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis.
T5099 Gefapixant Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
T4706 UDP disodium salt UDP is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction. UDP also ac
T7423 Diquafosol tetrasodium Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium improves tear film stability and visual functio
TQ0002 A-317491 A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
T7805 GW791343 (HCl) GW791343 is a P2X7 allosteric modulator.
T10207 A 438079 A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T14076 A 839977 A 839977 is a P2X7 selective antagonist and the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta[1]. It blocks BzATP-evoked calci
T14920 CE-224535 CE-224535 is an antagonist of P2X7 receptor.
T11177 Elinogrel Elinogrel can be given orally and intravenously and has a strong anti-platelet effect.Elinogrel is an effective, direct acting, competitive, reversible platelet P2Y12 antagonist (I
T10466 BAY-1797 BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak
T10560 P2X3 antagonist 34 P2X3 antagonist 34 is a selective and orally active antagonist of P2X3 homotrimeric receptor (IC50s: 25 nM, 92 nM, and 126 nM for the human, rat, and guinea pig P2X3 receptor
T14844 BX430 BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μ
T16162 Mutated EGFR-IN-1 Mutated EGFR-IN-1 is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant, and T790M resistance mutant.
T16338 Norgestimate metabolite Norelgestromin Norelgestromin is one of the active metabolites of norgestimate.It is a steroidal progestin used in contraceptive patches, where it is combined with the estrogen ethinyl estradiol.
T5513 RO3 RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
T16572 Prasugrel (Maleic acid) Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist and inhibits ADP-induced platelet aggregation. Prasugrel Maleic acid is a thienopyridine and prodrug.
T16672 PSB-1114 tetrasodium PSB-1114 tetrasodium shows >50-fold selectivity versus the P2Y4 (EC50: 9.3 μM) and P2Y6 (EC50: 7.0 μM) receptors. PSB-1114 tetrasodium is an effective, enzymatically stable, and
T8582 Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI) Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI) is a P2Y12 inhibitor.
T12568 PSB-12062 PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
T16399 Opiranserin Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist
T21059 Ticagrelor metabolite M5 Ticagrelor metabolite M5 is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster and more consistent i
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