||Naloxone hydrochloride is a specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
||Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminot
||Meptazinol Hcl, a unique centrally opioid analgesic, is used as a narcotic antagonist with analgesic properties.
||Loperamide Hydrochloride is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
||Dextromethorphan HBr monohydrate
||Methyl analog of DEXTRORPHAN that shows high-affinity binding to some areas of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (recept
||Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN
||Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may ca
||Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed
||Docusate is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzyme elevations during
||Naltrexone is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.
||Noscapine Hydrochloride is the orally available hydrochloride salt of the opioid agonist noscapine, a phthalide isoquinoline alkaloid derived from the opium poppy Papaver somniferu
||Alvimopan is a synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competit
||L-Menthol is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to
||MCOPPB trihydrochlride is a nociceptin receptor agonist.
||Nalfurafine(TRK-820) is an opioid κ-selective agonist; has been approved in Japan for treatment of itch in patients with chronic kidney disease.
||Matrine, an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
||Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflav
||ADL5859 HCl is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.
||Nalmefene antagonizes the effects of opioids by competing for the opioid receptors in the CNS.
||DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
||SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.
||DAMGO TFA (78123-71-4(Free base))
||Potent, selective agonist of Mu-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines and chemokine recepto
||PZM21 is an effective and selective μ opioid receptor agonist (EC50: 1.8 nM).
||CID16020046 is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
||Asimadoline HCl is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline has also been shown to be used in the treatment of irritable bowel syndrome.
||N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid recepto
||Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP) and δ-opioid (DOP) receptor,
||Cannabidiol is GPR55 and weak CB1 antagonist (IC50s: 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50: 27.5 μM). It also a weak agonist a
||Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP. EM-2-IR fibers or
||Tyr-Gly-Gly-Phe-Met-OH, is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor.
||[Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and -opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
||Valorphin has opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM.
||Dermorphin is agonist of μ-opioid receptor (MOR) agonist.
||Aticaprant (CERC-501) is a potent and centrally-penetrant antagonist of the kappa-opioid receptor (Ki: 0.807 nM).
||LY2795050 is a novel specific κ-Opioid Receptor antagonist (IC50: 0.72 nM).
||Endomorphin 1 is a high affinity and selective agonist of the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM).
||Adrenorphin(3TFA) is an agonist of μ-opioid receptor(Ki :12 nM).
||β-Casomorphin, bovine(2TFA) is an opioid peptide isolated from casein peptone
||β-Casomorphin, human(TFA) is an opioid receptor agonist.
||Deltorphin I(TFA) is an agonist of δ-opioid receptor.
||Deltorphin 2(TFA) is an agonist of δ opioid receptor(IC50:0.41 nM)
||Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at opioid-like NOP receptor
||Naltrindole hydrochloride is a highly potent and selective antagonist of non-peptide δ opioid receptor(Ki of 0.02 nM).
||Norbinaltorphimine dihydrochloride is a potent and selective antagonist of κ opioid receptor.
||Opioid receptor modulator 1
||Opioid receptor modulator 1 is a modulator of opioid receptor.
||Bevenopran is an antagonist of peripheral μ-opioid receptor.
||DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potent antinociceptive activity. DP
||Endomorphin 2 TFA
||Endomorphin 2 TFA, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. a high affinity, highly selective agonist of the μ-opioid recept
||GSK1521498 free base (hydrochloride)
||GSK1521498 free base (hydrochloride) is being used for the treatment of disorders of compulsive consumption of food, alcohol, and drugs. GSK1521498 free base (hydrochloride) is a
||GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and drugs. GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist.
||GSK1521498 free base
||GSK1521498 free base is a potent and selective antagonist of μ-opioid receptor. GSK1521498 free base also has the potential for disorders of compulsive consumption of food, alcoho
||Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.
||ROCK-IN-1 is a potent ROCK inhibitor(IC50 of 1.2 nM , ROCK2).
||(R,S)-Ivosidenib is the less active enantiomer of Ivosidenib .
||Nociceptin is a 17-amino-acid polypeptide that is structurally related to the opioid peptide dynorphin A.
||[D-Ala2]-Leucine enkephalin is a delta opioid agonist used to study the signaling pathway of delta opioid receptors.
||Nociceptin (1-13), amide
||Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes.
||Gluten Exorphin C
||Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respecti
||Prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
||ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.
||N-terminally acetylated Leu-enkephalin
||Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu
||Akuammidine shows anti-inflammatory and anti-asthmatic properties, it has opioid analgesic activity, it shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 an
||Akuammigine has in vitro antimalarial activity. Akuammigine competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68.
||Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro.
||[Met5]-Enkephalin, amide TFA
||[Met5]-Enkephalin, amide TFA is a δ opioid receptors agonist as well as putative ζ (zeta) opioid receptors.