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Opioid Receptor
T0102 Naloxone hydrochloride Naloxone hydrochloride is a specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
T0137 Mirtazapine Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminot
T0201 Meptazinol hydrochloride Meptazinol Hcl, a unique centrally opioid analgesic, is used as a narcotic antagonist with analgesic properties.
T0209 Loperamide hydrochloride Loperamide Hydrochloride is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
T0262 Dextromethorphan HBr monohydrate Methyl analog of DEXTRORPHAN that shows high-affinity binding to some areas of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (recept
T0478 Progesterone Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN
T0783 Mianserin hydrochloride Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may ca
T0918 Trimebutine Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed
T0929 Docusate sodium Docusate is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzyme elevations during
T0963 Naltrexone hydrochloride Naltrexone is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.
T0981 Noscapine hydrochloride Noscapine Hydrochloride is the orally available hydrochloride salt of the opioid agonist noscapine, a phthalide isoquinoline alkaloid derived from the opium poppy Papaver somniferu
T11198 Endomorphin 2 TFA Endomorphin 2 TFA,  displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. a high affinity, highly selective agonist of the μ-opioid recept
T11478 GSK1521498 free base (hydrochloride) GSK1521498 free base (hydrochloride) is a selective antagonist of the μ-opioid receptor (MOR). It is being used for the treatment of disorders of compulsive consumption of food, a
T11478L GSK1521498 free base GSK1521498 free base is a potent and selective antagonist of the μ-opioid receptor. GSK1521498 free base also has the potential for disorders of compulsive consumption of food, al
T11479 GSK1521498 GSK1521498 is a selective antagonist of the μ-opioid receptor (MOR). It is being used for the treatment of disorders of compulsive consumption of food, alcohol, and drugs.
T12168 Naloxone benzoylhydrazone Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at opioid-like NOP receptor
T12169 Naltrindole hydrochloride Naltrindole hydrochloride is a highly potent and selective antagonist of non-peptide δ opioid receptor(Ki of 0.02 nM).
T12241 Norbinaltorphimine dihydrochloride Norbinaltorphimine dihydrochloride is a potent and selective antagonist of κ opioid receptor.
T12314 Opioid receptor modulator 1 Opioid receptor modulator 1 is a modulator of opioid receptor.
T1242 Alvimopan Alvimopan is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competi
T13414 ZT 52656A hydrochloride ZT 52656A is a selective agonist of kappa opioid, and used for the prevention or alleviation of pain in the eye.
T13419 ROCK-IN-1 ROCK-IN-1 is a potent ROCK inhibitor(IC50 of 1.2 nM , ROCK2).
T13438 (R,S)-Ivosidenib (R,S)-Ivosidenib is the less active enantiomer of Ivosidenib .
T1407 L-Menthol L-Menthol is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to
T14551 Bevenopran Bevenopran is an antagonist of peripheral μ-opioid receptor.
T15165 DPI-3290 DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potent antinociceptive activity. DPI
T20435L Leuphasyl TFA Leuphasyl TFA is an amid peptide, a δ-opioid receptor agonist, is a degradation resistant long-acting Leu-enkephalin analog used to study the signaling pathway of delta opioid rec
T2071 MCOPPB trihydrochlride MCOPPB trihydrochlride is a nociceptin receptor agonist.
T21422 Methylnaltrexone bromide Methylnaltrexone, used in form of methylnaltrexone bromide, is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone acts to reverse some of the si
T2388 Nalfurafine hydrochloride Nalfurafine(TRK-820) is an opioid κ-selective agonist; has been approved in Japan for treatment of itch in patients with chronic kidney disease.
T2870 (+)-Matrine Matrine, an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T3417 Amentoflavone Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflav
T4236 AR-M 1000390 hydrochloride AR-M 1000390 (hydrochloride), also known as ARM-390, is a low-internalizing nonpeptidic δ-selective opioid receptor agonist; derivative of SNC 80. Does not trigger acute desensiti
T4351 DAMGO DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
T4386 PZM21 PZM21 is an effective and selective μ opioid receptor agonist (EC50: 1.8 nM).
T4407 SR17018 SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.
T4411 DAMGO TFA (78123-71-4(Free base)) Potent, selective agonist of Mu-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines and chemokine recepto
T4478 CID 16020046 CID16020046 is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
T4691 Asimadoline hydrochloride Asimadoline HCl is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline has also been shown to be used in the treatment of irritable bowel syndrome.
T5158 N-Desmethylclozapine N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid recepto
T5167 Cebranopadol Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP) and δ-opioid (DOP) receptor,
T6175 ADL5859 HCl ADL5859 HCl is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.
T6221 Nalmefene hydrochloride Nalmefene antagonizes the effects of opioids by competing for the opioid receptors in the CNS.
T6553 JTC801 JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.
T6902 Naloxone HCl Dihydrate Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose.
T7173 [Leu5]-Enkephalin [Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and µ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
T7211 Tyr-Gly-Gly-Phe-Met-OH Tyr-Gly-Gly-Phe-Met-OH, is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor.
T7218 Endomorphin 2 Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP.  EM-2-IR fibers
T7306 Valorphin Valorphin has opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM.
T7404 Dermorphin Dermorphin is agonist of μ-opioid receptor (MOR) agonist.
T7567 Adrenorphin(3TFA) Adrenorphin(3TFA) is an agonist of μ-opioid receptor(Ki :12 nM).
T7567L Adrenorphin 3TFA(88377-68-8(free base)) Adrenorphin(3TFA) is an agonist of μ-opioid receptor(Ki :12 nM).
T7576 β-Casomorphin, bovine(2TFA) β-Casomorphin, bovine(2TFA) is an opioid peptide isolated from casein peptone
T7576L β-Casomorphin, bovine TFA(72122-62-4(free base)) β-Casomorphin, bovine TFA is an opioid peptide isolated from casein peptone
T7613 β-Casomorphin, human(TFA) β-Casomorphin, human(TFA) is an opioid receptor agonist.
T7637 Deltorphin I(TFA) Deltorphin I(TFA) is an agonist of δ-opioid receptor.
T7639 Deltorphin 2(TFA) Deltorphin 2(TFA) is an agonist of δ opioid receptor(IC50:0.41 nM)
T7665 [Leu5]-Enkephalin TFA(58822-25-6(free bas)) [Leu5]-Enkephalin is the most potent δ-receptor ago
T8455 Spinorphin Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.
T8557 N-terminally acetylated Leu-enkephalin Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu
T8571 ML-184 ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 µM.
TN3367 Akuammidine Akuammidine shows anti-inflammatory and anti-asthmatic properties, it has opioid analgesic activity, it shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 an
TN3368 Akuammigine Akuammigine has in vitro antimalarial activity. Akuammigine competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68.
TN5017 Sideritoflavone Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro.
TP1071 Nociceptin Nociceptin is a 17-amino-acid polypeptide that is structurally related to the opioid peptide dynorphin A.
TP1179L Porcine dynorphin A(1-13) acetate(72957-38-1 free base) Porcine dynorphin A(1-13) acetate is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Exposure to dynorphin A (1-13) causes a
TP1254 [Met5]-Enkephalin, amide TFA (60117-17-1 free base) [Met5]-Enkephalin, amide TFA is a δ opioid receptors agonist as well as putative ζ (zeta) opioid receptors.
TP1367 [D-Ala2]leucine-enkephalin [D-Ala2]-Leucine enkephalin is a delta opioid agonist used to study the signaling pathway of delta opioid receptors.
TP1793 Nociceptin (1-13), amide Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes.
TP1793L Nociceptin (1-13) amide TFA (178064-02-3 free base) Nociceptin (1-13), amide is a potent agonist Opioid receptor-like1 (ORL1) receptor with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membr
TP1813L Dynorphin A 1-10 acetate(79994-24-4 free base) Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with
TP1832 Gluten Exorphin C Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respecti
TP1905 DADLE Prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
TP2036L DPDPE TFA (88373-73-3 free base) DPDPE TFA is selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vi
TP2040L Dynorphin A acetate(80448-90-4 free base) Dynorphin A acetate is an Endogenous kappa receptor agonist.
TP2040L Dynorphin A acetate(80448-90-4 free base) Dynorphin A acetate is an Endogenous kappa receptor agonist.
TP2050L CTAP(TFA) (103429-32-9 free base) CTAP TFA is a potent, highly selective, and brain penetrant  antagonist of μ-opioid receptor with IC50 of 3.5 nM. It displays over 1200-fold selectivity over δ opioid (IC50=450
TP2322L beta-Neoendorphin acetate(77739-21-0 free base) beta-Neoendorphin acetate is an agonist of κ-opioid receptor
TQ0082 Aticaprant Aticaprant (CERC-501) is a potent and centrally-penetrant antagonist of the kappa-opioid receptor (Ki: 0.807 nM).
TQ0091 LY2795050 LY2795050 is a novel specific κ-Opioid Receptor antagonist (IC50: 0.72 nM).
TQ0267 Endomorphin-1 Endomorphin 1 is a high affinity and selective agonist of the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM).
TWS0414 Cannabidiol Cannabidiol is GPR55 and weak CB1 antagonist (IC50s: 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50: 27.5 μM). It also a weak agonist a
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