T1913 |
MK3697 |
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM). |
T2613 |
Almorexant |
Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
T2710 |
TCS 1102 |
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). |
T3177 |
Orexin 2 Receptor Agonist |
Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist. |
T3347 |
PF3274167 |
PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. |
T3722 |
MK1064 |
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA). |
T6140 |
SB334867 |
SB-334867 is a selective orexin-1 (OX1) receptor antagonist. |
T6155 |
Almorexant HCl |
Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respective |
T6658 |
SB408124 |
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. |
T4965 |
TCS-OX2-29 |
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1. |
T2742 |
Aloin |
Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor. |
TQ0237 |
Lemborexant |
Lemborexant (E-2006) is a reversible and orally active dual antagonist of the orexin OX1 and OX2 receptors (IC50s: 6.1 nM and 2.6 nM). |
T11186 |
EMPA |
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively) |
T16328 |
Nitroaspirin |
Nitroaspirin is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces significant induction of ce |
T5500 |
DORA-22 |
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory |