| T11186 | EMPA | EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively) |
| T16328 | Nitroaspirin | Nitroaspirin is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces significant induction of ce |
| T1913 | MK3697 | MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM). |
| T2613 | Almorexant | Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
| T2710 | TCS 1102 | TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). |
| T3177 | Orexin 2 Receptor Agonist | Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist. |
| T3347 | PF3274167 | PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. |
| T3722 | MK1064 | MK-1064 is a selective orexin 2 receptor antagonist (2-SORA). |
| T4965 | TCS-OX2-29 | TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1. |
| T5500 | DORA-22 | DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory |
| T6140 | SB334867 | SB-334867 is a selective orexin-1 (OX1) receptor antagonist. |
| T6155 | Almorexant HCl | Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respective |
| T6658 | SB408124 | SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. |
| TQ0237 | Lemborexant | Lemborexant (E-2006) is a reversible and orally active dual antagonist of the orexin OX1 and OX2 receptors (IC50s: 6.1 nM and 2.6 nM). |
