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Nrf2
T10733 CDDO-EA CDDO-EA is an activator of NF-E2 related factor 2/antioxidant response element (Nrf2/ARE).
T11251 Ezetimibe ketone Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone (EZM-K) is a phase-
T12253 Nrf2-IN-1 Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
T13467 (±)-BAY-1251152 (±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.
T15474 Hesperin Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
T1593 Ezetimibe Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.
T16352 NSC23925 NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
T2915 Bardoxolone CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC
T2A2486 5,7,3',4',5'-Pentamethoxyflavone 3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adjuvant sensitizer to
T3012 Mangiferin Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.
T4360 ML385 ML385 is a new-type and selective NRF2 inhibitor.
T5364 TBHQ Tert-butylhydroquinone (tBHQ) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
T5S1805 5,7-Dihydroxychromone 1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts neuroprotective ef
T6919 Omaveloxolone Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T8704 4-hydroxyphenyl acetate 4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer
T9112 (-)-Perillaldehyde (-)-Perillaldehyde shows antibacterial activity.
TMA0237 Carlinoside Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclear translocation and
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 and NF-κB pathwa
TN1058 Pelargonidin chloride Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 s
TN1151 Procyanidin B4 Procyanidin B4 reveals significant antioxidant activity
TN1461 Butin Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by ac
TN1548 Daidzin 6''-O-malonate Daidzin 6''-O-malonate may have anticancer activity.
TN1621 Eriodictyol-7-O-glucoside Eriodictyol-7-O-glucoside and epicatechin appears to be responsible for the antioxidant activity of pistachio skin.
TN1670 Ganodermanondiol Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and
TN1989 Niga-ichigoside F1 Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.
TN2166 Rupestonic acid Rupestonic acid derivatives have an anti-influenza virus activity, they inhibit IAV by up-regulating HO-1-mediated IFN response.
TN2272 Tigloylgomisin H Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it func
TN3694 Coniferaldehyde Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dependent pathway in R
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells,
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neur
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. It can s
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Fl
TN4160 Goniothalamin Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cells, induce apoptosis
TN4234 Hydrangenol Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA) reaction, it has
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays poten
TN4583 Moringin Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune
TN5278 Zederone Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of
TN6711 toralactone Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism
TN6711 toralactone Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism
TQ0120 CDDO-Im CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
TQ0199 Ginsenoside Rh3 Ginsenoside Rh3 is a natural product extracted from Panax ginseng C. A. Mey. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.
TQ0211 Brusatol Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
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