| T0344 |
Miconazole |
Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. |
| T0358 |
Aminoguanidine hydrochloride |
Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy. |
| T0947 |
Dexamethason acetate |
Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuc |
| T1076 |
Dexamethasone |
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccha |
| T2738 |
Dehydroandrographolide |
Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees. |
| T2876 |
Flavone |
Flavons have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body. |
| T3408 |
eleutheroside-b |
Syringin is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects. |
| T3491 |
1400W dihydrochloride |
1400 W is a highly effective and specific inhibitor of inducible NOS2 (iNOS). |
| T3884 |
Neoandrographolide |
Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effect, might result fr |
| T6570 |
L-NAME hydrochloride |
L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively. |
| T5S0281 |
Tubuloside A |
Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes to its anti-inflamm |
| T4S0800 |
Demethyleneberberine |
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo |
| T4953 |
Neotuberostemonine |
Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary |
| T5681 |
ETHYL CAFFEATE |
In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-related signaling, i |
| T5676 |
(Z)-SU4312 |
(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively). |
| T5688 |
Micheliolide |
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response. |
| T5807 |
Stylopine hydrochloride |
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity. |
| T7206 |
2-Iminobiotin |
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 µM |
| T7191 |
Diphenyleneiodonium chloride |
Diphenyleneiodonium chloride(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 µM, respectively),and displays broad-spectrum bactericidal activity. |
| T2351 |
TAK875 |
TAK875 is a potent, selective and orally bioavailable GPR40 agonist. |
| T7474 |
7-Nitroindazole |
7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS. |
| T8213 |
Isolinderalactone |
Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM. |
| TN1150 |
Procyanidin B3 |
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. |
| TN1562 |
Dehydromiltirone |
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF-κB signaling path |
| TN2091 |
Polygalacin D |
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein |
| TN2232 |
Soyasaponin Ab |
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of soyasaponin Ab. |
| TN2327 |
Zedoarondiol |
Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequent |
| TN1058 |
Pelargonidin chloride |
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 s |
| TN1109 |
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid |
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells. |
| TN1116 |
Schisandrone |
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under active oxygen stress st |
| TN1171 |
1-Dehydro-6-gingerdione |
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist. |
| TN1222 |
23-epi-26-Deoxyactein |
23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-can |
| TN1238 |
3,4-O-Isopropylidene shikimic acid |
3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimental colitis induced |
| TN1516 |
Cnidicin |
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exh |
| TN1576 |
Diallyl disulfide |
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22. |
| TN1598 |
Dunnianol |
Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold and decrease cellula |
| TN1623 |
Escin IIB |
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching beha |
| TN1650 |
Friedelin |
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. |
| TN1949 |
Moracin C |
Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds. |
| TN1962 |
Myricetin 3-O-galactoside |
Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral inhibition of nitric o |
| TN2095 |
Pomiferin |
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory an |
| TN1006 |
Tirucallol |
Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutro |
| TN1086 |
Dehydroeburicoic acid |
Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas. |
| TN1118 |
Tormentic acid |
Tormentic acid has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties, |
| TN1406 |
Aromadendrin |
Aromadendrin is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhib |
| TN1465 |
Cannabigerol |
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 re |
| TN1524 |
Continentalic acid |
Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis. |
| TN1599 |
Eburicoic acid |
Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity, they prot |
| TN1622 |
Ermanin |
Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent activity at 40 ppm aga |
| TN1834 |
Kobusin |
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases throug |
| TN1890 |
Lupeol acetate |
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of |
| TN2223 |
Soyacerebroside I |
Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity. |
| T10107 |
3-Bromo-7-nitroindazole |
3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or iNOS. It affects the intercellular messenger NO synthesis thr |
| T13628 |
Curvularin |
Curvulin, naturally isolated from Campylobacter curvulans, is a fungal metabolite and a potent mycotoxin that inhibits cytokine-induced nitric oxide synthase (iNOS) with IC50 of 9. |
| T11518 |
GW274150 phosphate |
GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15 |
| T11518L |
GW274150 |
GW274150 shows less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 is a selective and NADPH-dependent inhibitor of human inducible nitric |
| T15697 |
L-NMMA acetate |
L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms that including NOS1, NOS2, and NOS3 (Ki: nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, |
| T11806 |
L-NIO dihydrochloride |
L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats. L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor |
| T16830 |
S-MTC |
S-MTC is a selective inhibitor of type I nitric oxide synthase. |
| T22419 |
(S)-Methylisothiourea sulfate |
(S)-Methylisothiourea sulfate is a potent inducible NO synthase (iNOS) inhibitor. |
| T3P2855 |
Chamigrenal |
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamig |
| T4S1616 |
Sanggenone D |
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it |
| TN2435 |
(-)-STYLOPINE |
(-)-STYLOPINE is a natural product from Chelidonium majus L |
| TN2440 |
Technical grade |
Technical grade is a natural from Magnolia sieboldii |
| TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by in |
| TN2641 |
15-Methoxypinusolidic acid |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid s |
| TN2775 |
2-Methoxystypandrone |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidati |
| TN3049 |
4-Methoxycinnamyl alcohol |
4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line. |
| TN3139 |
5alpha-Hydroxycostic acid |
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate. |
| TN3364 |
Agrimonolide |
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 |
| TN3366 |
Ailanthoidol |
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemoprevent |
| TN3482 |
Bakkenolide B |
Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma. |
| TN3539 |
Broussonin A |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activi |
| TN3575 |
Cannabichromene |
Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selecti |
| TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits canc |
| TN3609 |
Catalposide |
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO-1 induction is res |
| TN3635 |
Chlojaponilactone B |
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. |
| TMA1409 |
cis-Mulberroside A |
cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage. |
| TN3694 |
Coniferaldehyde |
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dependent pathway in R |
| TN3744 |
Cyclomorusin |
Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion gen |
| TN3805 |
Dehydrogeijerin |
Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of inflammatory disea |
| TN3839 |
Desoxo-narchinol A |
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO pr |
| TN3966 |
Epicatechin pentaacetate |
Epicatechin pentaacetate is a phenolic compound from the V. mullaha fruit extracts, the utilization of V. mullaha fruit as functional food with prospective pharmaceutical, nutraceu |
| TN4038 |
Eupatolide |
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. It can s |
| TN4050 |
Fargesone A |
Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1. |
| TN4064 |
Flavoglaucin |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Fl |
| TN4162 |
Goshonoside F5 |
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo. |
| TN4234 |
Hydrangenol |
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA) reaction, it has |
| TN4286 |
Isodunnianol |
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the |
| TN4291 |
Isofuranodiene |
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodien |
| TN4383 |
Kazinol U |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazi |
| TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays poten |
| TN4446 |
Longiferone B |
Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression. |
| TN4602 |
Myricananin A |
Myricadenin A exhibits anti-inflammatory activities in the iNOS assay with EC50 values of 18.1 uM. |
| TN4633 |
Neocryptotanshinone II |
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways. |
| TN4635 |
Neoechinulin A |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation o |
| TN4648 |
Nepetoidin B |
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated by MKP-5/NF-κB p |
| TN4675 |
Nortrachelogenin |
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, t |
| TN4683 |
Nyasol |
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhib |
| TMA1570 |
Sappanone A |
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 and NF-κB pathwa |
| TN5011 |
Shizukaol B |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by |
| TN5019 |
Siegeskaurolic acid |
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactiva |
| TN5021 |
Sikokianin C |
Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL. |
| TN5164 |
trans-Hinokiresinol |
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinok |
| TN5186 |
Triptoquinone A |
Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory activity, it preve |
| TN5192 |
Tuberosin |
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner. |
| TN5227 |
(+/-)-Vestitol |
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to be applied in the |
| TN5248 |
Voleneol |
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the p |
| TN5264 |
Xanthoxyletin |
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS prot |
| T19916 |
TRIM |
TRIM is an inhibitor of nNOS. |
| T7543 |
S-(2-aminoethyl) Isothiourea (dihydrobromide) |
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 µM, respective |
| TN2139 |
Regaloside B |
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity. |
| TN2139 |
Regaloside B |
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity. |
