首页AutophagyNOS
NOS
T0344 Miconazole Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
T0358 Aminoguanidine hydrochloride Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
T0947 Dexamethason acetate Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuc
T1076 Dexamethasone Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccha
T2738 Dehydroandrographolide Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.
T2876 Flavone Flavons have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body.
T3408 eleutheroside-b Syringin is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.
T3491 1400W dihydrochloride 1400 W is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
T3884 Neoandrographolide Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effect, might result fr
T6570 L-NAME hydrochloride L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively.
T5S0281 Tubuloside A Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes to its anti-inflamm
T4S0800 Demethyleneberberine Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo
T4953 Neotuberostemonine Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary
T5681 ETHYL CAFFEATE In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-related signaling, i
T5676 (Z)-SU4312 (Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
T5688 Micheliolide Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T5807 Stylopine hydrochloride Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
T7206 2-Iminobiotin 2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 µM
T7191 Diphenyleneiodonium chloride Diphenyleneiodonium chloride(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 µM, respectively),and displays broad-spectrum bactericidal activity.
T2351 TAK875 TAK875 is a potent, selective and orally bioavailable GPR40 agonist.
T7474 7-Nitroindazole 7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.
T8213 Isolinderalactone Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
TN1150 Procyanidin B3 Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
TN1562 Dehydromiltirone Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF-κB signaling path
TN2091 Polygalacin D Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein
TN2232 Soyasaponin Ab Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of soyasaponin Ab.
TN2327 Zedoarondiol Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequent
TN1058 Pelargonidin chloride Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 s
TN1109 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
TN1116 Schisandrone Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under active oxygen stress st
TN1171 1-Dehydro-6-gingerdione 1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
TN1222 23-epi-26-Deoxyactein 23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-can
TN1238 3,4-O-Isopropylidene shikimic acid 3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimental colitis induced
TN1516 Cnidicin Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exh
TN1576 Diallyl disulfide Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
TN1598 Dunnianol Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold and decrease cellula
TN1623 Escin IIB Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching beha
TN1650 Friedelin Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
TN1949 Moracin C Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
TN1962 Myricetin 3-O-galactoside Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral inhibition of nitric o
TN2095 Pomiferin Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory an
TN1006 Tirucallol Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutro
TN1086 Dehydroeburicoic acid Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
TN1118 Tormentic acid Tormentic acid has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,
TN1406 Aromadendrin Aromadendrin is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhib
TN1465 Cannabigerol Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 re
TN1524 Continentalic acid Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis.
TN1599 Eburicoic acid Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity, they prot
TN1622 Ermanin Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent activity at 40 ppm aga
TN1834 Kobusin Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases throug
TN1890 Lupeol acetate Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of
TN2223 Soyacerebroside I Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.
T10107 3-Bromo-7-nitroindazole 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or iNOS. It affects the intercellular messenger NO synthesis thr
T13628 Curvularin Curvulin, naturally isolated from Campylobacter curvulans, is a fungal metabolite and a potent mycotoxin that inhibits cytokine-induced nitric oxide synthase (iNOS) with IC50 of 9.
T11518 GW274150 phosphate GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15
T11518L GW274150 GW274150 shows less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 is a selective and NADPH-dependent inhibitor of human inducible nitric
T15697 L-NMMA acetate L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms that including NOS1, NOS2, and NOS3 (Ki: nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18,
T11806 L-NIO dihydrochloride L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats. L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor
T16830 S-MTC S-MTC is a selective inhibitor of type I nitric oxide synthase.
T22419 (S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate is a potent inducible NO synthase (iNOS) inhibitor.
T3P2855 Chamigrenal β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamig
T4S1616 Sanggenone D Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it
TN2435 (-)-STYLOPINE (-)-STYLOPINE is a natural product from Chelidonium majus L
TN2440 Technical grade Technical grade is a natural from Magnolia sieboldii
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by in
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid s
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidati
TN3049 4-Methoxycinnamyl alcohol 4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line.
TN3139 5alpha-Hydroxycostic acid 5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TN3364 Agrimonolide Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38
TN3366 Ailanthoidol Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemoprevent
TN3482 Bakkenolide B Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
TN3539 Broussonin A Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activi
TN3575 Cannabichromene Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selecti
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits canc
TN3609 Catalposide Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO-1 induction is res
TN3635 Chlojaponilactone B Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.
TMA1409 cis-Mulberroside A cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
TN3694 Coniferaldehyde Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dependent pathway in R
TN3744 Cyclomorusin Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion gen
TN3805 Dehydrogeijerin Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of inflammatory disea
TN3839 Desoxo-narchinol A Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO pr
TN3966 Epicatechin pentaacetate Epicatechin pentaacetate is a phenolic compound from the V. mullaha fruit extracts, the utilization of V. mullaha fruit as functional food with prospective pharmaceutical, nutraceu
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. It can s
TN4050 Fargesone A Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Fl
TN4162 Goshonoside F5 Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4234 Hydrangenol Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA) reaction, it has
TN4286 Isodunnianol Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the
TN4291 Isofuranodiene Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodien
TN4383 Kazinol U Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazi
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays poten
TN4446 Longiferone B Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.
TN4602 Myricananin A Myricadenin A exhibits anti-inflammatory activities in the iNOS assay with EC50 values of 18.1 uM.
TN4633 Neocryptotanshinone II Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation o
TN4648 Nepetoidin B Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated by MKP-5/NF-κB p
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, t
TN4683 Nyasol Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhib
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 and NF-κB pathwa
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by
TN5019 Siegeskaurolic acid Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactiva
TN5021 Sikokianin C Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL.
TN5164 trans-Hinokiresinol Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinok
TN5186 Triptoquinone A Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory activity, it preve
TN5192 Tuberosin Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner.
TN5227 (+/-)-Vestitol Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to be applied in the
TN5248 Voleneol 1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the p
TN5264 Xanthoxyletin Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS prot
T19916 TRIM TRIM is an inhibitor of nNOS.
T7543 S-(2-aminoethyl) Isothiourea (dihydrobromide) S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 µM, respective
TN2139 Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity.
TN2139 Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity.
  • 关注公众号
    - 超值特惠
    - 客户福利
    - 业界动态
    - 实用攻略
陶素的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)。