||Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
||Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid
||Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metap
||Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
||A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
||Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms.
||Triclabendazole has been used in trials studying Parasitic Disease.
||Thiabendazole is a benzimidazole derivative with anthelminthic property.
||Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
||Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
||AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1).
||Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used a
||Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
||Mebendazole is a hedgehog inhibitor， used as an antihelminthic.
||Mivobulin is an inhibitor of tubulin .
||Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle.
||S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.
||S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
||Tubulin inhibitor 6
||Tubulin inhibitor 6 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.
||Tubulin inhibitor 7
||Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines(tubulin polymerization(IC50 of 0.52 μM), K562 cell growth(IC50 of 11 nM)).
||Tubulin inhibitor 8
||Tubulin inhibitor 8 is an inhibitor of tubulin and multiple cancer cell lines(tubulin polymerization with an IC50 of 0.73 μM, K562 cell growth with an IC50 of 14 nM).
||Tubulin inhibitor 1
||Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization,with potent anti-tumor activity, induces cellular apoptosis casues and cellular mitotic arrest in th
||Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis,and displays potent antitumor activity.
||Verubulin hydrochloride is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent anticancer activity in
||OSIP-486823 is a microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.
||Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
||SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.
||Auristatin F is a potent cytotoxin. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).
||Soblidotin (Auristatin PE) is an inhibitor of tubulin polymerization. It also is a novel synthetic Dolastatin 10 derivative.
||Crolibulin is an inhibitor of small molecule tubulin polymerization.
||Indibulin decreases inter-kinetochoric tension, activates mitotic checkpoint proteins Mad2 and BubR1, produces aberrant spindles, and induces mitotic arrest and apoptosis. Indibul
||Ombrabulin hydrochloride is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
||Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
||Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an α/β unsaturated l
||Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and microtubule dynamics.
||VERU-111 is an effective and orally bioavailable α and β tubulin inhibitor (average IC50: 5.2 nM) against panels of melanoma and prostate cancer cell lines. VERU-111 inhibits tum
||Verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities.
||D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
||ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
||CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM) Arp2/3 complex, res
||Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
||ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activit
||Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle
||2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell prol
||INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
||Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine
||Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.
||Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM) in cell-free assays
||4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
||KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
||BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
||PE859 is a potent inhibitor of both tau and Aβ aggregation.
||HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
||VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
||MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
||KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
||SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in canc
||Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infest
||Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules ag
||INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
||CW069( IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
||Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
||Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
||Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM
||Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
||Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
||Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
||Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G
||Methylene Blue(IC50 of 1.9μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
||Monomethyl auristatin E
||Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) ac
||TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
||T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.
||BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
||Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.
||Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angi
||Taltobulin (HTI-286) is a potent tubulin inhibitor.
||Epothilone D (KOS 862) is an effective microtubule stabilizer.