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Microtubule Associated
T0009 Flubendazole Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T0186 Docetaxel trihydrate Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid
T0190 Vinorelbine Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metap
T0320 Colchicine Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
T0651 N-Phenylbenzylamine A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
T0714 Oxfendazole Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms.
T0838 Triclabendazole Triclabendazole has been used in trials studying Parasitic Disease.
T0938 Thiabendazole Thiabendazole is a benzimidazole derivative with anthelminthic property.
T0968 Paclitaxel Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
T1034 Docetaxel Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
T10428 AZ82 AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1).
T1121 Podophyllotoxin Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used a
T1152 Albendazole Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T1155 Mebendazole Mebendazole is a hedgehog inhibitor, used as an antihelminthic.
T12052 Mivobulin Mivobulin is an inhibitor of tubulin .
T1270 Vincristine sulfate Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle.
T12805 S-methyl DM1 S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.
T12823 S516 S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
T13224 Tubulin inhibitor 6 Tubulin inhibitor 6 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.
T13225 Tubulin inhibitor 7 Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines(tubulin polymerization(IC50 of 0.52 μM), K562 cell growth(IC50 of 11 nM)).
T13226 Tubulin inhibitor 8 Tubulin inhibitor 8 is an inhibitor of tubulin and multiple cancer cell lines(tubulin polymerization with an IC50 of 0.73 μM, K562 cell growth with an IC50 of 14 nM).
T13227 Tubulin inhibitor 1 Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization,with potent anti-tumor activity, induces cellular apoptosis casues and cellular mitotic arrest in th
T13228 Tubulysin D Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis,and displays potent antitumor activity.
T13298 Verubulin hydrochloride Verubulin hydrochloride is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent anticancer activity in
T13807 OSIP-486823 OSIP-486823 is a microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.
T1382 Griseofulvin Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
T13901 SS28 SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.
T14349 Auristatin F Auristatin F is a potent cytotoxin. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).
T14350 Soblidotin Soblidotin (Auristatin PE) is an inhibitor of tubulin polymerization. It also is a novel synthetic Dolastatin 10 derivative.
T15012 Crolibulin Crolibulin is an inhibitor of small molecule tubulin polymerization.
T15576 Indibulin Indibulin decreases inter-kinetochoric tension, activates mitotic checkpoint proteins Mad2 and BubR1, produces aberrant spindles, and induces mitotic arrest and apoptosis. Indibul
T16386 Ombrabulin hydrochloride Ombrabulin hydrochloride is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
T16387 Ombrabulin Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
T16543 Pironetin Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an α/β unsaturated l
T16997 Tasidotin hydrochloride Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and microtubule dynamics.
T17228 VERU-111 VERU-111 is an effective and orally bioavailable α and β tubulin inhibitor (average IC50: 5.2 nM) against panels of melanoma and prostate cancer cell lines. VERU-111 inhibits tum
T17229 Verubulin Verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities.
T1753 D64131 D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
T1758 ABT-751 ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
T1820 CK-636 CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM) Arp2/3 complex, res
T1910 Ansamitocin P-3 Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
T2060 LR-510444 ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activit
T2090 Lexibulin Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle
T2220 2-Methoxyestradiol 2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell prol
T2502 INH1 INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
T2511 Plinabulin Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine
T2543 Cabazitaxel Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.
T2802 Nocodazole Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM) in cell-free assays
T2937 4'-Demethylepipodophyllotoxin 4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
T3652 KRIBB11 KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
T4029 BTB-1 BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T4077 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation.
T4125 HSF1A HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
T4232 VCMMAE VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
T4677 MMAD MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
T5170 KHS101 hydrochloride KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
T5699 SSE15206 SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in canc
T6071 Parbendazole Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infest
T6075 Epothilone B Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules ag
T6180 INH6 INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
T6209 CW069 CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T6212 Combretastatin A4 Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
T6213 Vinorelbine Tartrate Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T6272 Fosbretabulin Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM
T6372 Albendazole Oxide Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
T6490 Epothilone A Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T6721 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T6864 Ixabepilone Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G
T6888 Methylene Blue Methylene Blue(IC50 of 1.9μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T6897 Monomethyl auristatin E Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) ac
T7003 TRx0237 mesylate TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
T8216 T-1101 tosylate T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.
T8492 BO-264 BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
TN1087 Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.
TQ0112 Tubulysin A Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angi
TQ0141 Taltobulin Taltobulin (HTI-286) is a potent tubulin inhibitor.
TQ0202 Epothilone D Epothilone D (KOS 862) is an effective microtubule stabilizer.
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