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Liver X Receptor
T1783 LXR623 WAY-252623 (LXR-623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
T1801 SR9243 SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
T3970 XL-652 BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM).
T6310 GW3965 HCl GW3965 HCl is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
T6690 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T5178 AZ876 AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
T5128 RGX-104 HCl RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE g
T5743 Gymnemagenin Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
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