首页AutophagyLipoxygenase
Lipoxygenase
T0477 Zileuton Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotri
T0646 Mesalamine Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHA
T1296 Aminopar Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T1401 Meclofenoxate hydrochloride Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, and mentally stimulati
T1420 Diethylcarbamazine citrate Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Loa loa. It is an inh
T1558 Resveratrol Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T1677 Montelukast Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of cli
T6485 Embelin Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T4347 ML355 ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
T6S1699 6-Shogaol 1. 6-Shogaol has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory
TJS0315 7,8-Dihydroxy-4-methylcoumarin 1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-o
T3879 Silychristin Silychristin is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.
T4571 Balsalazide Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
T5759 marmesin Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T5714 5-DEMETHYLNOBILETIN 5-DEMETHYLNOBILETIN is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.
TQ0180 Chebulagic acid Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
T3090 Abietic Acid Abietic Acid is the primary component of resin acid isolated from rosin.
T8002 3-Hydroxycoumarin 3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors
T8260 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
T8356 FPL 62064 FPL 62064 is a potent  dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively)
TN1255 3-O-Acetyl-11-hydroxy-beta-boswellic acid 3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
TN1291 5-Hydroxy-3',4',7-trimethoxyflavone 5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml
TN1244 3'-Demethylnobiletin 3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apopt
TN1016 Kukoamine A Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative stress and apoptos
TN1871 Ligustroside Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustroside shows moderate an
T10151 5-Lipoxygenase-In-1 5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
T10438 AZD 4407 AZD 4407 is a potent inhibitor of 5-lipoxygenase.
TN1182 11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent
T12784 RWJ 63556 RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
T11196 Enazadrem Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
T10719 CCT365623 hydrochloride CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
T10821 Cirsiliol Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
T10098 PGS-IN-1 PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS; IC50: 0.28 μM) and also inhibits 5-lipoxygenase (IC50: 1.05 μM).
T16503 PF-4191834 PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX
T13764 Lycopodine Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive component derived from
T22398 Phenidone Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound primarily used as a photographic developer.
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to
TN4331 Isotachioside Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
TN4783 Picralinal Picralinal has anti-inflammatory and analgesic effects.
TN5020 (+/-)-Sigmoidin A Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
TN5174 Trichosanatine Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine can alleviate oxi
T2807 Caffeic Acid Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities.
T2798 Esculetin Esculetin is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour
T21902 ML351 ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).
TN1097 Beta-boswellic acid Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
T6576 Malotilate Malotilate is a medicine used for the therapy of liver cirrhosis.
TN2330 Caffeic Acid 3-Methyl Phenethyl Ester Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. 
  • 关注公众号
    - 超值特惠
    - 客户福利
    - 业界动态
    - 实用攻略
陶素的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)。