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Immunology & Inflammation related
T4122 TAPI-1 trifluoroacetate (171235-71-5(free base)) TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
T6731 WYE-354 WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is
T4S1849 Tubeimoside III Tubeimoside III has anti-inflammatory, anti-tumor, and anti-tumorigenic activities, stronger than those of tubeimoside II.
T7522 GI 254023X GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM).
T8145 Benzyl cinnamate Benzyl cinnamate is a natural product isolated from various plant species,with anti-inflammatory activity.
TN1015 Meranzin Meranzin exhibits strong anti-inflammatory and analgesic activity.
TN1080 Kaji-ichigoside F1 Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats
TN1085 Dehydrotumulosic acid Dehydrotumulosic acid shows anti-inflammatory activity.
TN1111 Arnidiol Arnidiol has anti-inflammatory activity, it possesses marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
TN1144 Enmein Enmein shows significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml
TN1166 1,3,6-Tri-O-galloylglucose 1,3,6-Tri-O-galloylglucose shows anti-inflammatory activity.
TN1249 3-Epiursolic acid 3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tum
TN1256 3-O-Acetyl-16 alpha-hydroxytrametenolic acid 3-O-Acetyl-16 alpha -hydroxytrametenolic acid has inhibitory activities against AAPH-induced hemolysis of red blood cells, it shows a strong inhibitory activity against 12-O-tetrad
TN1355 Acanthoside B Acanthoside has inhibitory effects on the allergic inflammation.
TN1364 Ajugasterone C Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats.
TN1402 Arjungenin Arjungenin shows α²-glucuronidase inhibitory activity, it shows antiviral, and anti-inflammatory activities.
TN1438 beta-Amyrin acetate beta-Amyrin acetate has anti-inflammatory, antioxidant, and antidyslipidemic activities, it shows significant HMG-CoA-reductase and sEH inhibition.
TN1455 Bryodulcosigenin Bryodulcosigenin has anti-inflammatory effect, it shows potent inhibitory effects on EBV-EA induction.
TN1563 Dehydropachymic acid Dehydropachymic acid shows antiinflammatory activity.
TN1590 DL-alpha-Tocopherylacetate Dl-alpha-tocopheryl acetate is a dietary supplement.
TN1608 (-)-Epigallocatechin-3-(3''-O-methyl) gallate (-)-Epigallocatechin-3-(3''-O-methyl)gallate shows antioxidative, cytotoxic, antiallergic, and anti-inflammatory activities, it can negatively regulate basophil activation through
TN1697 Glucosyringic acid Glucosyringic acid has immunosuppressive effect, it can inhibit the proliferation of murine B lymphocytes in vitro.
TN1730 Heraclenol Heraclenol is a germination inhibitor in the parsley seeds. It has anti-inflammatory properties against the ear edema in mice produced by TPA. Heraclenol and heraclenin inhibit the
TN1782 Isolariciresinol Isolariciresinol has antioxidant and anti-inflammatory activities during an in vitro gastro-intestinal digestion of the Radix Isatidis extract (RIE).
TN1823 Kaempferol-3-O-galactoside Kaempferol-3-O-α²-d-galactoside has antioxidant, anti-inflammatory and antinociceptive activities.
TN1961 Myricetin 3-O-beta-D-glucopyranoside Myricetin 3-O-beta-D-glucopyranoside may have antioxidant, and anti-inflammatory activities.
TN2022 Oxoglaucine Oxoglaucine exerts immunomodulatory effect in vivo in a dose-dependent and protocol-dependent manner, it also exhibits significant antiplatelet aggregation activity against rabbit
TN2159 Robustine Robustine may have anti-inflammatory activity, it exhibits inhibition (IC 50 < or = 18.19 microM) of superoxide anion generation by human neutrophils in response to formyl- l-methi
TN2287 Turkesterone Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodulating and antistres
TN1133 Isocolumbin Isocolumbin has anti-inflammatory, and antimicrobial activities.
TN1506 Clemastanin B Clemastanin B has antioxidant and anti-inflammatory activities, it exerts its anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus at
TN1661 Ganoderic acid C2 Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Eps
TN2045 Pelargonidin-3-O-glucoside chloride Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflammatory, anti-estrog
TN2283 Tripterifordin Tripterifordin shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.
TN2308 Wilfortrine Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expre
TN1923 Mesaconine Mesaconine has cardiac effect, it also has anti-NF-κB activity. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and immune suppressio
TN2316 Xanthyletin Xanthyletin has anti-inflammatory, anti-tumor and anti-bacterial activities, it also inhibits symbiotic fungus cultivated by leaf-cutting ants.
T2S1334 Daphnetin 7-methyl ether Daphnetin 7-methyl ether has anti-inflammatory activity.
T3832 11-O-Galloylbergenin 11-O-Galloylbergenin shows good antioxidant and antiplasmodial activities, it shows significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats, and it
T3834 8-Epideoxyloganic acid 8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, t
T3S0289 Araloside X Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA me
T4S0818 Chasmanine Chasmanine, hypaconitine, and deoxyaconitine are anti-inflammatory pharmacodynamic components in Heishunpian (HSP) with positive relations with HSP efficacy. Chasmanine has insecti
T4S1472 Cucurbitacin S Cucurbitacins from Wilbrandia ebracteata have analgesic effects. Cucurbitacin S has anticancer and antiinflammatory activities.
TL0013 Heraclenin Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it h
TN2766 2'-Hydroxydaidzein 2'-Hydroxygenistein is an isoflavonoid phytoalexin, it suppresses chemical mediators in inflammatory cells, may have value in treatment and prevention of central and peripheral inf
TN2792 2-Oxopomolic acid 2-Oxopomolic acid shows cytotoxic activity, it shows a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin. 2-Oxopomolic acid shows
TN2928 3-Epicorosolic acid 3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemoprev
TMA2008 3-Hydroxy-1,5-diphenyl-1-pentanone (+)-3-Hydroxy-1,5-diphenyl-1-pentanone exhibits both immunomodulatory and anti-tumor activity.
TN2973 3'-O-Methylmurraol 3'-O-Methylmurraol may have potential anti-inflammatory activity, it exhibits inhibition (IC50 ≤ 7.31 ug/mL) of superoxide anion generation by human neutrophils in response to fo
TN3395 Alpinone 3-acetate Alpinone 3-acetate has anti-inflammatory activity, it can inhibit 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation in a mouse model of ear edema.
TN3403 Alternariol monomethyl ether Alternariol monomethyl ether,an Alternaria toxin, is a strong mutagen in Escherichia coli strain ND-160. Alternariol monomethyl ether has genotoxic properties, it can cause oxidati
TN3447 Arjunglucoside I Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat. It also shows antiproliferative activity against the
TN3473 Axillarin Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-indu
TN3576 Cannabisin F Melongenamides B-D and Cannabisin F have anti-inflammatory activity, they exhibit inhibitions of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC
TN3706 Coronarin A Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC prolife
TN3725 Cucurbitadienol Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first commit
TN3815 Delta 7-avenasterol Delta 7-avenasterol has antioxidant activity.
TN3879 Docosyl caffeate Docosyl caffeate shows moderate antioxidant activity in DPPH and ABTS scavenging assays, it also has significant anti-inflammation activity. Docosyl caffeate exhibits potent elasta
TN4045 Evofolin C Evofolin C and its acetate show strong antifungal and antibacterial activity. Evofolin C exhibits potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide
TN4103 Ganoderic acid K Ganoderic acid K is an angiotensin-converting enzyme inhibitor. It has anti-tumor, and anti-inflammatory activities.
TN4132 Germanicol Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migrati
TN4185 Hautriwaic acid Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polys
TN4189 Hedychenone Hedychenone has anti-inflammatory activity, it also shows potent in vitro cytotoxic activity against cancerous cells.
TN4214 Hispanone Hispanone possesses anti-inflammatory activity, it shows inhibition of superoxide anion generation and elastase release.
TN4241 Hyptadienic acid Hyptadienic acid exhibits moderate cytotoxicity against HepG2 cells.It also shows a marked anti-inflammatory effect, it also exhibits strong antitumor-promoting activity in an in v
TN4388 Kielcorin Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils
TN4406 Lamiide Lamiide has anti-inflammatory activity in carrageenin-induced paw edema test. It shows lipid peroxidation inhibition on rat-brain phospholipid peroxidation.
TN4493 Mannioside A Mannioside A has anti-inflammatory activity, inhibits carrageenan-induced paw edema in the rat.
TN4506 (+)-Matairesinol (+)-Matairesinol exhibits immunomodulatory activity; it also shows inhibition of the discoloration of yellowtail dark muscle.
TN4529 Methyl 3-carbazolecarboxylate Methyl 3-carbazolecarboxylate is a natural product from Micromelum sp.
TN4659 Nimbin Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbin requires to elici
TN4771 Phyltetralin Phyltetralin has antihyperuricemic activity.
TN4804 Platycoside A Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG
TN4811 Plumieride Plumieride has plant growth inhibiting properties, it shows strong fungitoxicity against some dermatophytes causing dermatomycosis to animals and human beings. Plumieride also has
TN4831 Procumbide Procumbide has anti-inflammatory activity.
TN4838 Pseurotin A Pseurotin A has immunosuppressive activity, it inhibits immunoglobulin E(IgE) production in vitro.It shows a moderate effect against the phytopathogenic bacteria Erwinia carotovora
TN4841 Ptaquiloside Ptaquiloside shows genotoxicity, it also has carcinogenic effects. Ptaquiloside has immunosuppressive effects, it reduces NK cell activities by enhancing metallothionein expression
TN4921 Rubelloside B Rubelloside B exhibits immunological enhancement effect.
TN4967 Scoparinol Scoparinol has sedative, anti-inflammatory, analgesic, and diuretic actions.
TN5062 Stigmast-4-ene-3,6-dione Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties.
TN5069 Stigmastane-3,6-dione Stigmastane-3,6-dione has anti-inflammatory activity. 5 alpha-Stigmastane-3,6-dione shows antifeedant activity against bell weevils.
TMA0627 Taxiresinol Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Ta
TN5151 Tomentin Tomentin has anti-inflammatory effects, it can inhibit the formation of λ-carrageenan footpad edema at 58%.
TMA2235 Triptobenzene H Triptobenzene H shows the significant immunosuppressive activity.
TN5221 (-)-Variabilin Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; α
TN5223 Vasicinolone Vasicinolone has anti-inflammatory, and antimicrobial activities.
TN5227 (+/-)-Vestitol Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to be applied in the
TN5228 Vestitol Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose
TN5262 Wittifuran X Wittifuran X has antioxidant and anti-inflammatory activities.
TN5280 Zeylenol (-)-Zeylenol shows antifeedant activity. Zeylenol shows inhibitory activity toward the root growth of Lactuca sativa. Zeylenol probably possesses anti-inflammatory activity by inhi
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