T0097 |
MRT67307 |
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induce |
T1558 |
Resveratrol |
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc. Resveratrol is a potent |
T1902 |
BAY 11-7082 |
BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21. |
T1934 |
Bay 11-7085 |
BAY 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM). |
T2055 |
WS3 |
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. |
T2081 |
LY2409881 trihydrochloride |
LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher. |
T2106 |
WS6 |
WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. |
T2118 |
SC514 |
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression. |
T3049 |
TPCA1 |
TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes. |
T3094 |
PS1145 |
PS-1145 is a specific IKK inhibitor with IC50 of 88 nM. |
T3736 |
Olivetol |
Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabin |
T6141 |
IMD 0354 |
IMD-0354 is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway. |
T6165 |
Bardoxolone Methyl |
Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities. |
T6176 |
IKK16 |
IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
T6186 |
TRAM34 |
TRAM-34(Kd=20 nM),an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1),does not block cytochrome P450. The selective activi |
T6326 |
BMS345541 |
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. |
T6771 |
AZD3264 |
AZD3264 is a new type IKK2 inhibitor. |
T7081 |
CCCP |
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane poten |
T5162 |
MRT67307 HCl (1190378-57-4(free base)) |
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively). |
T3775 |
Armepavine |
Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomer |
T5209 |
INH14 |
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ). |
T5540 |
GSK8612 |
GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1, pIC50: 6.8). |
TQ0306 |
MLN120B |
MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM). |
T1639 |
Amlexanox |
Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils |
T2765 |
Rosmarinic acid |
Rosmarinic acid has shown to contain antioxidant,anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance,Alzheime |
TN1828 |
Kahweol |
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibitin |
T7951 |
TBK1/IKKε-IN-5 |
TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively). |
T10472L |
Bay 65-1942 free base |
Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ. |
T14508 |
Bay 65-1942 hydrochloride |
Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ. |
T14567 |
BI605906 |
BI605906 is an inhibitor of IKKβ. When assayed at 0.1 mM ATP, the IC50 value is 380 nM. |
T14669 |
BMS-066 |
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively. |
T12659 |
(Rac)-BAY-985 |
(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy. |
T15559 |
TBK1/IKKε-IN-2 |
TBK1/IKKε-IN-2 is a TBK1 and IKKε dual inhibitor. |
T13097 |
TBK1/IKKε-IN-1 |
TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM). |
T10477 |
BAY-985 |
BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy. |
T11633 |
IKK-IN-1 |
IKK-IN-1 is an inhibitor of IKK. |
T15558 |
GSK319347A |
GSK319347A is a TBK1 and IKKε dual inhibitor (IC50s: 93 nM and 469 nM, respectively). GSK319347A inhibits IKK2 (IC50: 790 nM). |
T15564 |
IMD-0560 |
IMD-0560 is a novel inhibitor of IκB kinase β. |
T8542 |
BMS-345541 hydrochloride |
BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively). |
T2S0606 |
Bakkenolide A |
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways. |
T5S0689 |
Demethylwedelolactone |
Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells. |
T5S0993 |
Kurarinone |
Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflamma |
TJS1779 |
Protosappanin A |
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal path |
TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by in |
TN2775 |
2-Methoxystypandrone |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidati |
TN3219 |
7,8-Didehydrocimigenol |
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated E |
TN3486 |
Bakkenolide IIIa |
Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-κB signaling. |
TN3517 |
Bisacurone |
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidatio |
TN3539 |
Broussonin A |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activi |
TN3614 |
Cearoin |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS |
TN3635 |
Chlojaponilactone B |
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. |
TN3726 |
Cudraflavone B |
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, |
TN3806 |
Dehydroglyasperin C |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neur |
TN4162 |
Goshonoside F5 |
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo. |
TN4318 |
Isophysalin A |
Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) production inhibiting activities |
TN4383 |
Kazinol U |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazi |
TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays poten |
TN4635 |
Neoechinulin A |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation o |
TN4683 |
Nyasol |
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhib |
TN4779 |
Physalin O |
Physalin O possesses anti-inflammatory activity, it exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities. |
TN4986 |
Selinidin |
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation. |
TN5153 |
Torilin |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 |