||Ziprasidone hydrochloride monohydrate
||Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
||Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
||Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associated with serum enzyme
||Hydroxyzine pamoate is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major met
||Diphenylpyraline Hcl is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine reuptake inhibitor.
||Chlorprothixene is a typical antipsychotic drug of the thioxanthene class，which was the first of the series to be synthesized.
||Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a typical antipsychoti
||Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabo
||Cetirizine dihydrochloride is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, and pollen-induced ast
||Antazoline hydrochloride, a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.
||Mizolastine (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives.
||Clemastine Fumarate is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.
||Roxatidine Acetate hydrochloride
||Roxatidine Acetate hydrochloride is a specific and competitive histamin H2-receptor antagonist. It inhibits gastric acid secretion and ulcer formation.
||Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is though
||Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effect
||Azelastine Hydrochloride is a phthalazinone derivative with antihistaminergic activity.
||Betahistine hydrochloride is a histamine analog and H1 receptor agonist that serves as a vasodilator.
||Betahistine mesilate is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchia
||Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
||Dimenhydrinate is an ethanolamine and histamine antagonist with anti-allergic activity.
||Diphenhydramine HCl (Benadryl) is a histamine H1 antagonist used as an antitussive and antiemetic. It is also used for pruritus and dermatoses, for hypersensitivity reactions, as a
||Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
||Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
||Promethazine HCl(NSC-231688), the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, moderate affinity for 5-
||Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecul
||Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmaco
||Cimetidine is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC AC
||Ranitidine Hydrochloride is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the actio
||Cinnarizine is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DI
||Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
||Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.
||(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.
||Triprolidine Hydrochloride is a histamine H1 antagonist used in allergic rhinitis, asthma.
||Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its acti
||BMY-25271 is an antagonist of histamine H2 receptor.
||Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.
||Cetirizine D4 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
||Cetirizine D8 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
||Chlorcyclizine hydrochloride is an antagonist of histamine H1.
||Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
||H3 receptor antagonist 1
||H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist.
||Loratadine is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTA
||Doxepin D3 Hydrochloride
||Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is a
||Meclizine hydrochloride is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
||Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and lim
||FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM.
||H3R-IN-1 Hydrochloride is a histamine receptor 3 (H3R) inverse agonist.
||H4R antagonist 1
||H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.H4R antagonist 1 is a potent and highly selective histami
||JNJ-39758979 displays good anti-inflammatory and antipruritic activity. JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM fo
||JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13
||Propionyl-L-carnitine hydrochloride is used for the treatment of the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.
||MK-0249 is a potent antagonist of histamine H3 receptor (human H3, Ki : 1.7 nM).
||Niperotidine is an antagonist of histamine H2-receptor.
||Pyrilamine maleate is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenter
||PF-03654746 Tosylate is selective antagonist of histamine H3 receptor with high brain penetration.
||(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).
||Tripelennamine hydrochloride is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.
||ReN 1869 hydrochloride is a novel, selective antagonist of histamine H1 receptor.
||ROS 234 dioxalate
||ROS 234 dioxalate is a potent antagonist of H3(pKB of 9.46 for Guinea-pig ileum H3-receptor)
||Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less antichol
||SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM).
||Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
||Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depres
||Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II h
||Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-
||Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.
||Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistaminic activity.
||Chlorphenamine is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.
||Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50=25 nM). Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 r
||Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of hi
||Lavoltidine strongly suppresses gastric acid secretion and also induces hypergastrinemia. Lavoltidine is an orally active, irreversible, and highly effective histamine H2-receptor
||Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
||Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and o
||Famotidine is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the basolateral membrane
||Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM).
||Toreforant is an effective and selective histamine H4 receptor antagonist (Ki at the human receptor: 8.4 nM).
||Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
||Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RN
||Cetirizine D8 dihydrochloride
||Cetirizine D8 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
||WZ4141 is an intermediate in compound synthesis.
||Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
||Hydroxyzine hydrochloride is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its maj
||Carbinoxamine Maleate Salt
||Carbinoxamine Maleate is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties.
||JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.
||Levocetirizine, the active R-enantiomer of cetirizine, represents a new second-generation histamine H1 antagonist.
||Ebastine (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the
||Desloratadine is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1
||Alcaftadine is an H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis.
||Osthole, a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.
||Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function
||Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.
||Protopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
||Ranitidine is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
||Dioxopromethazine is a target-based classification of drug and available in a number of countries worldwide.
||VUF10460 is a non-imidazole histamine H4 receptor agonist.
||Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1
||S-38093 is a brain-penetrant antagonist of the H3 receptor (Ki: 8.8/1.44/1.2 μM, for rat/mouse/human).
||Betahistine is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma
||I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300
||Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action.
||MOZ-IN-3 is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
||Ac-CoA Synthase Inhibitor1
||ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
||Mequitazine is an effective, nonsedative and long-acting histamine H1 antagonist.
||Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.
||Acrivastine is a short-acting histamine 1 receptor antagonist.
||Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold,
||Lodoxamide is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.
||Decloxizine dihydrochloride is a histamine 1 receptor antagonist.
||H4 Receptor antagonist 1
||H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
||Ciproxifan is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM).
||Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
||Bepotastine is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7).
||Histamine, an organic nitrogen compound, works on target cells in the mammalian brain by stimulating of Histamine 1/2.
||Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
||Mebhydrolin is a specific histamine H1 receptor antagonist.
||Pitolisant hydrochloride is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM).
||JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.
||Metiamide is a histamine H2-receptor antagonist .
||LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
||Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
||Betazole hydrochloride is an agonist of H2 receptor.
||6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
||Ganoderic acid C2
||Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Eps
||(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
||Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the
||Rhodiocyanoside A has antiallergic activity, it exhibits inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP IgE and inhibits th
||3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
||4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.
||Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histami
||Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and C inhibit the hista
||Roseoside possesses strong antioxidant properties, inhibiting lipid oxidation by 86.4, at 50 microg/mL. Roseoside has insulinotropic activity, enhances insulin release from the β-
||Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows pote
||Bavisant (JNJ-31001074) is a selective and orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition.
||GSK189254A (GSK189254) is a new, potent and specific histamine H3 receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3).