||Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabut
||AUY922 (NVP-AUY922) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).
||NVP-BEP800, a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.
||Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
||VER-50589 is a potent HSP90 inhibitor.
||VER-49009 is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).
||BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).
||Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
||KNK437, a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).
||Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.
||Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates heat shock factor-1 and
||ML346 is a novel activator of Hsp70.
||NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).
||Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
||XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell pro
||Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp9
||Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
||17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
||SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
||SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough
||Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
||KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
||HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resis
||PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
||VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over H
||HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
||PF-04929113 Mesylate, a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM).
||Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
||MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 µM in vitro) through its ability to inhibit members o
||JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
||HSP27 inhibitor J2
||HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a
||Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.
||Feretoside is a natural product extracted from the barks of E. ulmoides. It is an HSP inducer.
||HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).
||Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably re
||(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
||Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apo
||AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
||AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
||CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 induction (IC50: 19 nM).
||Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
||Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molec
||Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor.
||Gamitrinib TPP hexafluorophosphate
||Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial m
||KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
||Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol b
||TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).
||4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop
||Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
||Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cells, induce apoptosis
||Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic acid shows antimicrob
||Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation by down-regulation
||Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-60 cancer cell line
||HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.
||Arimoclomol maleate (BRX-220) is a heat shock protein (HSP) co-inducer.
||Ethoxyquin is an antioxidant used in animal feeds.
||Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the investigation of fibrosis.
||DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
||2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects
||KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.