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HMG-CoA Reductase
T0672 Pravastatin sodium Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T0683 Mevastatin Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T0687 Simvastatin Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
T1207 Lovastatin Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
T1487 Fluvastatin sodium salt Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
T1510 Rosuvastatin calcium Rosuvastatin, a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
T1664 Meglutol Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the
T1676 Rosuvastatin Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mev
T3116 Atorvastatin Calcium Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
T3698 alpha-Asarone Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
T6450 Clinofibrate Clinofibrate(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglycer
T6994 SR12813 SR-12813 is a pregnane X receptor (PXR) agonist.
T4717 25-Hydroxycholesterol 25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also play
TN1377 alpha-Spinasterol α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inh
TN1733 Hesperetin 7-O-glucoside Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA r
TN2111 Prunin Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells
T12092 Monacolin J Monacolin J is a cholesterol biosynthesis inhibitor.
T10070 2'-Ethyl Simvastatin 2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
T20765 Atorvastatin Atorvastatin is an orally active inhibitor of HMG-CoA reductase,is a lipid-lowering agent (human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively
T11572 HMG499 HMG499 is a potent and selective HMG-CoA reductase inhibitor (IC50: 0.41 μM). HMG499 can prevent the statins-induced accumulation of HMGCR, reduce serum cholesterol levels, and de
T10767 Cerivastatin sodium Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the proliferation and invas
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