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Glucokinase
T0247 Acarbose Acarbose is an inhibitor of α-Glucosidases with antihyperglycemic activity.
T0714 Oxfendazole Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
T10751 Cefetrizole Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
T11741 KAN0438757 KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
T11749 KDM4-IN-2 KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T12056 MK-0941 free base MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.
T12142 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
T13130 Terphenyllin Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
T14212 AMG-1694 AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increas
T14365 AZ PFKFB3 26 AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively[1]. AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an I
T15159 Dorzagliatin Dorzagliatin is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
T16480 PF-04991532 PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
T21344 Duvoglustat hydrochloride Duvoglustat is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hypergly
T2455 PFK015 PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
T3104 LY2608204 LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T3105 PFK158 PFK-158 is an effective and specific inhibitor PFKFB3.
T3235 Rebaudioside A Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor.
T3260 3PO 3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
T3312 AM2394 AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 increases the affinity o
T3386 Kaempferitrin Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempf
T3871 Sitogluside Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has efficient and inexpensive neuroprotectant effect, to co
T3S1612 kuwanon G 1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes m
T3S2072 n-Butylidenephthalide 1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(5) 2.35
T4049 Genz-123346 free base Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
T4280 LTI291 LTI-291 is a glucocerebrosidase (Gcase) activator.
T5489 Tryptophan, N-indol-3-ylacetyl- (6CI) Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may also be used in th
T5690 4',7-DIMETHOXY-5-HYDROXYFLAVONE 4',7-DIMETHOXY-5-HYDROXYFLAVONE can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1)
T6723 Voglibose Voglibose, an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and various disorders caused
T6S0535 Pinoresinol diglucoside 1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
T6S1371 Isovitexin 1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
T6S2122 Ginkgolic acid C13:0 1.Ginkgolic acid C13: 0exhibits the highest α-glucosidase inhibitory activity.
T7028 LICOCHALCONEC Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, an
T8202 Kaempferol 3-gentiobioside Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays a carbohydrate enzym
T8260 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
T8319 Butyl isobutyl phthalate Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
TL0008 Gigantol Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast c
TN2130 Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside Quercetin 3-O-rutinoside-(1†’2)-O-rhamnoside shows α±-glucosidase inhibitory activity, it has anti-diabetic potential.
TN3487 Balanophonin Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial activity against car
TN3745 Cyclomusalenone Cyclomusalenone is a potent α-glucosidase inhibitor.
TN4174 Guajadial Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Receptors Modulators (S
TN4793 Pinoresinol diacetate Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
TN5090 Tachioside Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows antiobesity activ
TN5094 Tangshenoside I Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as the index compound.
TN5192 Tuberosin Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner.
TQ0055 AMG-3969 AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
TQ0300 Conduritol B epoxide Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
TQ0308 Castanospermine Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
TWS0787 Oroxin A Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity against α-glucosidase an
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