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T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0124 Selamectin Selamectin is distributed by Zoetis. It is a topical parasiticide and antihelminthic used on dogs and cats. Parasites is be maimed by selamectin stimulating glutamate-gated chlorid
T0256 Lithium citrate tribasic tetrahydrate Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and metabolic in the brai
T0313 Evans blue Evans blue is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
T0326L L-Glutamine L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T0426 Piracetam Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T0675 Topiramate Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepatic injury and large
T0875 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effect
T10432L AZD-8529 mesylate AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-2
T10573 BMT-145027 BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50: 47 nM).
T11032 DHPG DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluR linked to phospholipase D. DHPG ((RS)-3,5-DHPG) is an amino acid that can be used as a selective and potent agonist fo
T11311L Foliglurax Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
T11906 LY 541850 LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and meta
T11907 LY2140023 LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agonist.
T11911 LY3020371 hydrochloride LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist wi
T12025 MFZ 10-7 hydrochloride MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM
T12118 MSOP MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).
T12520 Pomaglumetad methionil Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
T12717 Basimglurant Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
T13318 VU0650786 VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anx
T13319 VU0652835 VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
T13323 VU6012962 VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
T14389 AZD 9272 AZD 9272 is a antagonist of brain penetrant mGluR5.
T1443 Memantine hydrochloride Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T14615 Biphenylindanone A Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.
T15090 Decoglurant Decoglurant is a negative allosteric modulator of mGluR2 and mGluR3 developed as an antidepressant.
T15275 Fenobam Fenobam is a non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kds: 54 and 31 nM for rat and human recombinant mGlu5 receptors). Fenobam shows inverse agon
T15369 gamma-DGG gamma-DGG is a competitive blocker of AMPA receptor.
T15456 GYKI53655 hydrochloride GYKI53655 hydrochloride is an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA).
T15618 JNJ-46281222 JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory poten
T15619 JNJ-46778212 JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
T15692 L-APB L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
T15819 LY377604 LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
T15823 LYPLAL1-IN-1 LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
T15830 M-110 M-110 inhibits PIM-1 and PIM-2 with similar (IC50s: 2.5 μM) and it also inhibits the proliferation of prostate cancer cell lines (IC50s: 0.6 to 0.9 μM). M-110 is a highly selecti
T15944 M77976 M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4) (IC50: 648 μM).
T16524 Philanthotoxin 74 dihydrochloride Philanthotoxin 74 dihydrochloride is an AMPAR antagonist. Philanthotoxin 74 dihydrochloride inhibits GluR3 and GluR1 (IC50s: 263 and 296 nM, respectively).
T17248 VU6001376 VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).
T1884 Ampalex Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and m
T2053 ADX 47273 ADX-47273 is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
T2194 Chicago Sky Blue 6B Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice.
T22641 CDPPB CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
T23515 VU 29 VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2
T2497 MPEP hydrochloride MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).
T2811 Harmine hydrochloride Harmine hydrochloride is extracted from Peganum Harmala Genus.
T3010 Xanthurenic Acid Xanthurenic acid, a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).
T3379 Decanoic Acid Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
T3451 JNJ42153605 JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
T3464 PHCCC PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8.
T3473 ATPO ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
T3477 E4CPG E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.
T3478 Ro 67-7476 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.
T3479 (RS)-MCPG (RS)-MCPG is a non-selective group I/II metabotropic glutamate receptor antagonist.
T3482 CFMTI CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000-fold than mGluR5.
T3483 FTIDC FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibition of FTIDC for mGl
T3484 (±)-trans-ACPD (±)-trans-ACPD is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the gro
T3486 3-MATIDA
T3539 Lu AF21934 Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
T3565 UV0155041 UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
T3957 Farampator Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
T4113 NBQX disodium salt Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
T4500 ADX88178 ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
T4573 Cyclothiazide Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic
T5083 L-Cysteic acid monohydrate L-Cysteic acid is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange of aspartate and in
T5509 FPTQ FPTQ is an antagonist of mGluR1.
T5884 Chelidamic acid Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
T6022 LY404039 LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
T6160 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
T6457 CTEP CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.
T6468 D-glutamine D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T6562 Latrepirdine Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.
T6598 MPEP MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
T6725 VU 0357121 VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
T6726 VU 0361737 VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat rec
T6727 VU 0364770 VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.
T6871 L-Glutamic acid monosodium salt L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
T7178 CNQX CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
T7292 FITM FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).
T7304 DNQX DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
T7494 TCN 238 TCN 238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
T7515 MTEP hydrochloride MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
T7579 1-BCP 1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
T7706 LY404187 LY404187 is a positive allosteric modulator of AMPA receptors
T7823 IDRA-21 IDRA-21 is a positive AMPA receptor modulator.
T8434 SIB-1757 SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)
T8435 YM90K hydrochloride YM90K hydrochloride is an antagonist of AMPA receptor.
T8457 NPS2390 NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)
T8626 4-oxo-1,4-dihydroquinoline-2-carboxylic acid 4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
T8779 HBT1 HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to liga
T8862 ML 254 ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and sui
TQ0094 JNJ-40411813 JNJ-40411813 (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
TQ0114 CMPDA CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
TQ0289 LY450108 LY450108 is a potentiator of the AMPA receptor.
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