| T0024 | Primidone | Primidone is an anticonvulsant of the pyrimidinedione class. |
| T0028 | 4-Amino-3-hydroxybutyric Acid | 4-Amino-3-Hydroxybutanoic Acid is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparation of HIV-1 inhibit |
| T0048 | Nikethamide | Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical c |
| T0051 | Urethane | Urethane was an antineoplastic agent .Now is used for other medicinal purposes. |
| T0128 | Vigabatrin | Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate transaminase responsible for the catabolism of γ-aminobutyric acid. Off-label u |
| T0128L | Vigabatrin Hydrochloride | Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly inhibits the catabolism of GABA by GABA transaminase. |
| T0169 | Nefiracetam | Nefiracetam are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions. |
| T0508 | 4-Aminobutyric acid | 4-Aminobutyric acid is the most common inhibitory neurotransmitter in the central nervous system. |
| T0675 | Topiramate | Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepatic injury and large |
| T0883 | Homotaurine | Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also |
| T0954 | Anestan | Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE |
| T0958 | Penicillin G sodium salt | Penicillin G sodium is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most |
| T1065 | Baclofen | Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminob |
| T1089 | Etomidate | Etomidate is a GABAA receptor agonist, with a short-acting sedative, hypnotic, and general anesthetic properties. |
| T1128 | Oxiracetam | Oxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is utilized for the treatment of cognitive impairments. |
| T1240 | Flumazenil | Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing |
| T1300 | Propofol | Propofol is an intravenous anesthetic agent used for induction and maintenance of general anesthesia. |
| T1396 | Bemegrid | Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning. |
| T1413 | Pentetrazol | Pentylenetetrazol is a GABA(A) receptor antagonist, that displays activity as a central nervous system and respiratory stimulant. |
| T1602 | Valproic acid sodium salt | Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blood. Although the me |
| T1673 | Acamprosate calcium | Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems, used for treating alcohol dependence. |
| T1860 | AWD 131-138 | AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist. It shows potent anticonvulsant and anxiolytic properties in rodent models. |
| T2067 | NS 11394 | NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) al |
| T2196 | Fipronil | Fipronil is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by |
| T2339 | Apalutamide | Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. |
| T2407 | Tiagabine | Tiagabine is an Anti-epileptic Agent. The physiologic effect of tiagabine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
| T2749 | Ginkgolide A | Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immun |
| T2775 | Baicalin | Baicalin is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties. |
| T2850 | (+)-Bicuculline | Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucu |
| T2990 | Phenibut | Phenibut is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA). |
| T2998 | Dihydromyricetin | Dihydromyricetin is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyri |
| T3318 | Wogonoside | Wogonoside acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor. |
| T3644 | U93631 | GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- cur |
| T4176 | rac-BHFF | Rac-BHFF is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anx |
| T6355 | (R)-baclofen | (R)-baclofena, a derivative of gamma-aminobutyric acid, is commonly utilized for the treatment of spasticity. |
| T6507 | Gabapentin HCl | Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. |
| T7000 | Tiagabine hydrochloride | Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake i |
| T4440 | Saclofen | Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This comp |
| T4363 | CGP 52432 | CGP52432 is a very potent antagonist of GABAB receptors (IC50 = 85 nM). |
| T3S2259 | Methyl eugenol | 1. Methyleugenol (ME) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of |
| T7064 | Valproic Acid | Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms o |
| T3927 | Phellopterin | Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. |
| T4522 | SSD114 hydrochloride | SSD114 is a novel GABAB receptor positive allosteric modulator. |
| T4688 | Pipequaline hydrochloride | Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely |
| T4655 | Pipequaline | Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely |
| T4682 | Allopregnanolone | Allopregnanolone is under investigation for the treatment of Super-Refractory Status Epilepticus.Allopregnanolone has been investigated for the treatment of Severe Postpartum Depre |
| T4993 | Afloqualone | Afloqualone is a agonist of GABA receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. Afloqualone is an analogue of methaqualone. It has |
| T5330 | Fluralaner | Fluralaner is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head membranes (IC50: 455 pM). |
| T5375 | Loreclezole | Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors. |
| T0702 | Gabapentin | Gabapentin is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
| T0627 | beta-Alanine | β-Alanine is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA r |
| T5734 | (+)-BORNEOL | (+)-BORNEOL is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. |
| T5880 | Aminooxyacetic acid hemihydrochloride | Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. |
| T7165 | Basmisanil | Basmisanil is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairm |
| T7136 | AZD6280 | AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder. |
| T7622 | Gabazine | Gabazine is an antagonist of GABAA receptors (Ki : 74-150 nM) |
| T7721 | GANAXOLONE | Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor, acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effec |
| T7557 | Guvacine hydrochloride | Guvacine hydrochloride is an inhibits of GABA uptake (IC50 : 10 μM) |
| TQ0023 | Lorediplon | Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep. |
| TQ0040 | ONO-8590580 | ONO-8590580 is a negative allosteric modulator of GABAA α5. |
| TQ0119 | Cirsimaritin | Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. It has antibacterial, anti-inflammation, anti-tumor, antioxidant, renal protection. |
| TQ0151 | L-655708 | L-655708 is an effective inverse agonist of the α5 subunit-selective GABAA receptor (Ki: 0.45 nM). |
| T7794 | Zuranolone | Zuranolone is an agonist of GABAA receptor. |
| T7793 | 6-(4-Methoxyphenyl)-3-pyridazinamine | 6-(4-Methoxyphenyl)-3-pyridazinamine is a GABAA receptor antagonist |
| T7803 | Gaboxadol (hydrochloride) | Gaboxadol (hydrochloride) is a GABAA receptor agonist. |
| T3403 | Glabridin | Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may pos |
| T0349 | Riluzole | Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS. |
| T8193 | Thujone | Thujone is an inhibitor of ACh with an IC50 value of 24.7μM. |
| T8268 | 6,2'-Dihydroxyflavone | 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. |
| T8036 | 6-Methylflavone | 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
| T8040 | Cholesterol myristate | Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor |
| T3S2100 | Securinine | (-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist. |
| T8162 | Cannabidivarin | Cannabidivarin is a potent inhibitor against gamma 2 subunit of GABAA receptors. it may serve as a novel drug with definite control over childhood absence epilepsy. |
| T7699 | AZD-7325 | AZD-7325 is a GABA-Aα2,3 -selective receptor modulator. |
| TN1027 | beta-Amyrin | beta-Amyrin has antiviral, hepatoprotective, antinociceptive, anti-inflammatory, it retard acute inflammation in rat model of periodontitis. |
| TN1591 | DL-Menthol | DL-Menthol has short term toxicity in rats, it plays a role in the induction of surgical anesthesia in fishes, related at least in part to the activation of GABAA receptors, and of |
| TN1717 | Guvacine | Guvacine can enhance the inhibition of spinal neurones by GABA. |
| TN1842 | Kushenol I | Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant |
| TN1420 | Bacopaside I | Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 mice via immune-m |
| TN1432 | Bacopasaponin C | Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property. |
| TN2268 | Tetrahydromagnolol | Tetrahydromagnolol can activate cannabinoid (CB) receptors. |
| T12043 | (-)-Bicuculline methobromide | (-)-Bicuculline methobromide is a potent antagonist of GABAA receptor . |
| T12044 | (-)-Bicuculline methochloride | (-)-Bicuculline methochloride is a potent antagonist of GABAA receptor. |
| T11061 | DMCM hydrochloride | DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA zaerxep3 receptor subtypes. For sp1, s |
| T14571 | Bifenazate | Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm[1] and it also is a positive allosteric modulator of GABA receptor[2]. |
| T10757L | Cenobamate | Cenobamate, a sodium channel blocker, enhances GABAergic transmission. It has a potential to be a versatile CNS drug. |
| T14938 | CGP 36742 | CGP 36742 is a selective antagonist of the GABAB receptor that can penetrate the blood-brain barrier after peripheral administration (IC50: 32 μM). It is useful in the treatment |
| T10869L | CP-409092 | CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity. |
| T15212 | Emamectin Benzoate | Emamectin Benzoate, by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel |
| T15380 | Gidazepam | Gidazepam is an GABA receptor channels agonist. |
| T12867 | SCH 50911 hydrochloride | SCH 50911 hydrochloride is a selective, orally-active and competitive antagonist of γ-Aminobutyric acid B GABA(B) receptor(IC50 : 1.1 μM). |
| T11137 | (E)-GABAB receptor antagonist 1 | (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antag |
| T11277 | FG 7142 | FG 7142 also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulatio |
| T11350 | GABAB receptor antagonist 1 | (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective and negative alloste |
| T10456 | Bamaluzole | Bamaluzole is an agonist of GABA receptor extracted from patent WO 2012064642 A1. |
| T15737 | Lesogaberan | Lesogaberan is an effective and selective GABAB receptor agonist (EC50: 8.6 nM for human recombinant GABAB receptors). For rat brain GABAB and GABAA receptors, the binding affinity |
| T19624 | Fasoracetam | Fasoracetam is a modulator of GABA receptor potentially for the treatment of attention deficit hyperactivity disorder. |
| T11686 | Isotanshinone I | Isotanshinone I with IC50s of 1.13 μM and 0.432 μM for α-glucosidase and AGE, respectively. Isotanshinone I has inhibitory activity against α-glucosidase and formation of AGE, |
| T16581 | Progabide | Progabide is an agonist of the gamma-aminobutyric acid receptor. |
| T16717 | Radequinil | Radequinil is a benzodiazepine receptor partial inverse agonist. Rade quinil binds to GABA(-) and GABA(+) ligand (Kis: 5.15 and 6.11 nM, respectively). |
| T16794 | RO 4938581 | RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 1 |
| T16811 | RWJ-51204 | RWJ-51204 is a partial agonist of GABA(A) receptor (Ki: 0.2-2 nM). |
| T11822 | LAU159 | LAU159 is a functionally selective positive α1β3 GABA(A) receptor modulator(EC50 : 2.2 μM). |
| T12867L | SCH 50911 | SCH 50911 is (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid and is a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) re |
| T17144 | TPA 023 | TPA 023 is an agonist of the GABAA α2/α3 subtype-selective (Ki: 0.19-0.41 nM). |
| T17215 | Valnoctamide | Valnoctamide inhibits benzodiazepine-refractory status epilepticus. Valnoctamide acts directly on GABAA receptors. |
| T17306 | Arbaclofen hydrochloride | Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to spinal cord damage |
| T8572 | CL 218872 | CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α |
| T8639 | Phenibut (hydrochloride) | Phenibut (hydrochloride) is a GABA mimetic that acts as an agonist at GABAB receptors, blocks α2δ subunit-containing voltage-gated calcium channels, stimulates dopamine receptor |
| T8568 | Suritozole | Suritozole is a negative modulator at the gamma-aminobutyric acidA (GABAA) receptor |
| T8630 | Baclofen hydrochloride | Baclofen hydrochloride is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, especially that due t |
| T4S1616 | Sanggenone D | Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it |
| T9113 | Myristicin | Myristicin is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also has anti-inflammato |
| TN3351 | Aflatrem | Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitte |
| TN3702 | (-)-Corlumine | Corlumine exhibits spasmolytic and GABA antagonist activity. |
| TN3868 | Dihydroxyaflavinine | Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.Dihydroxyaflavinine shows oral toxicity to the fall armywor |
| TN4298 | Isohyenanchin | Isohyenanchin is the potent antagonist of RDLac homo-oligomers, it is also a weak antagonist of ionotropic GABA receptors. |
| TN4322 | Isopulegol | Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive m |
| TN4440 | Limonexic acid | Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte again |
| TN5089 | Tabernanthine | Tabernanthine shows affinity for opiate receptors, it can decrease morphine and cocaine self-administration in rats, it may be effective in treating addiction to opioid and stimula |
| TN5147 | Tilifodiolide | Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal |
| T8664 | SSD114 hydrochloride | SSD114 hydrochloride is a GABAB receptor positive allosteric modulator. |
| T13690 | Etifoxine hydrochloride | Etifoxine is an anxiolytic and anticonvulsant drug. Unlike benzodiazepines, etifoxine appears to produce its anxiolytic effects by binding to β2 and β3 subunits of the GABAA rec |
| T11307 | Fluxametamide | Fluxametamide is a novel isoxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels, acts as an antagonist of GABA- and glutamate-gated c |
| T0710 | L-Cycloserine | L-cycloserine irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in increased levels of ga |
| T2983 | 3,4,5-Trimethoxycinnamic acid | 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. |
| T2940 | 6-Hydroxyflavone | 6-Hydroxyflavone is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It is reported in leaves of Barleria prionitis Linn. (a common |
| T11349 | GABAA receptor agent 1 | GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor. |
| TMS0418 | Dihydroergotoxine mesylate | It is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging. |
| T8887 | 2'MeO6MF | 2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dam |
| T7595 | L-DAB HBR | L-DAB HBR is an inhibitor of GABA transaminase (IC50 > 500 μM). |
| T3741 | (-)-borneol | (-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM. |
